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Showing 1 to 20 of 57 for “"Legionella pneumophila"”.
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Phasenvariation bei Legionella pneumophila: Vergleichende Proteomanalyse von virulenten und avirulenten Legionella pneumophila-Stämmen unter Anwendung der zweidimensionalen Gelelektrophorese
… eines avirulenten und virulenten Stammes von Legionella pneumophila Sg1 Subgruppe OLDA unter Anwendung der zweidimensionalen Gelelektrophorese. Die Stämme unterliegen einer spontanen LPS-Phasenvariation und unterscheiden sich phänotypisch in multiplen Eigenschaften. Es zeigten sich different …
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Molekularbiologische Studien zur Pathogenität und Ökologie von Legionella pneumophila
Legionella pneumophila, der Erreger der Legionärskrankheit, ist ein Umweltkeim mit Verbreitung in aquatischen Habitaten. Die Keime sind in der Lage, sich intrazellulär in eukaryontischen Zellen, wie Makrophagen, Monozyten und Protozoen zu vermehren. Die erfolgreiche Besiedlung ökologischer Nischen, …
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Virulence and pathogenic mechanisms of <i>Legionella pneumophila</i>
Strains of <i>Legionella pneumophila</i> which were virulent for guinea pigs were passaged on laboratory media such that they became avirulent. Virulent/avirulent pairs of strains were compared in an attempt to identify potential virulence or pathogenic factors. <br></br><br></br>Virulent forms …
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Host cell death in Legionella pneumophila pathogenesis and immunity
<p><em>Legionella pneumophila</em> is an intracellular pathogen that causes a severe, atypical pneumonia termed Legionnaires' disease. Upon entering the host cell, <em>L. pneumophila</em> resides in a membrane-bound vacuole, in which the bacterium evades lysosomal fusion and replicates. The …
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Funktionale und molekulare Charakterisierung des Pad-Proteins von Legionella pneumophila
… vorliegenden Arbeit wurde das Pad-Protein von Legionella pneumophila mit zell- bzw. molekularbiologischen sowie immunochemischen Methoden charakterisiert. Mittels Einbau des mutierten Pad-Locus, kodiert auf dem Plasmid pCS-25, in das Genom der L. pneumophila Stämme WH88 (Serogruppen 6) bzw. …
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Elucidating Human Inflammasome Responses To Legionella Pneumophila And Lipopolysaccharide Variants
… macrophages is poorly understood. Here, we use Legionella pneumophila, a vacuolar intracellular gram-negative bacterium, to elucidate the functions of human GBPs on inflammasome responses in macrophages. We determined that human GBP1 is essential for maximal inflammasome responses to L. …
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Secretion and Environmental Biochemistry of Legionella pneumophila in Corrosive Water
Legionella pneumophila and other opportunistic pathogens of drinking water pose important problems at the interface of biology, environmental engineering, public health, and governance. In this thesis, I explore the molecular mechanisms permitting survival of L. pneumophila in built water systems …
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Dictyostelium als Wirtsmodell und Funktionsanalyse des Virulenzfaktors Mip aus Legionella pneumophila
Legionella pneumophila wurde erstmals 1977 beschrieben, nachdem der Erreger aus dem Lungengewebe eines Patienten isoliert wurde, der an einer schweren atypischen Pneumonie erkrankt war. Das Bakterium zeichnet sich durch ein duales Wirtssystem aus und kann sich sowohl in Protozoen als auch in …
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Nutrient availability modulating physiology and pathogenicity of <i>Legionella pneumophila</i>
A virulent strain of <i>Legionella pneumophila</i> serogroup 1 was established in continuous culture under defined iron-replete conditions at pH 6.9. Iron-limitation and extremes of pH (6.0 and 7.8) influenced the growth and metabolism of <i>L. pneumophila</i>, as manifested by increased metabolic …
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The colonisation of treated water systems by <i>Legionella pneumophila</i>
… developed to investigate the ecology of <i>L. pneumophila</i>. The inoculum was derived from a calorifier responsible for an outbreak of Legionnaires' disease and contained virulent <i>L. pneumophila</i>a serogroup 1 along with associated microorganisms including protozoa. The model system was …
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Molekularbiologische Studien zur Bedeutung der Flagelle für die Virulenz von Legionella pneumophila
Legionella pneumophila, der Erreger der Legionärskrankheit, ist ein fakultativ intrazelluläres, ubiquitär vorkommendes Umweltbakterium. Die Rolle, die Flagelle und Motilität der Legionellen bei der Infektion von Protozoen oder humanen Zellen spielen können, ist bisher noch nicht geklärt. Um etwas …
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Isolation of Legionella Pneumophila From Well-Maintained Emergency Showers and Eyewash Stations
Legionella pneumophila is a gram-negative bacterium responsible for Legionnaire's disease, and is commonly transmitted via aerosolized water. Legionella colonization of emergency eyewash and shower stations may pose an exposure hazard to users of these stations. There is little information about …
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Environmental regulation of the growth, physiology and virulence of <i>Legionella pneumophila</i>
Members of the <i>Legionellaceae</i> cause respiratory infections in man; the most severe, pneumonic form is known as Legionnaires' disease. Of the 39 species described to date 16 have been associated with human disease, however the majority of reported cases of legionellosis are caused by …
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The role of biofilms in Legionella pneumophila transmission in drinking water distribution system
… the persistence and transmission of pathogenic Legionella pneumophila (L. pneumophila), thus raise human health concerns. L. pneumophila cells can accumulate in biofilms, be protected from disinfection by biofilms, and then be released from biofilms with detached biofilm materials or by the …
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Klonierung und Sequenzierung der zur Lipopolysaccharid-Biosynthese notwendigen Gene von Legionella pneumophila Serogruppe 1
… bindet, konnte für den virulenten Stamm RC1 von Legionella pneumophila Serogruppe 1 Subgruppe OLDA eine spontane instabile LPS-Mutante isoliert werden. Die Mutante zeigte eine Phasenvariation des Epitops, sowie einen Verlust der Virulenz und Serumresistenz. Um Zugang zum molekularen Mechanismus …
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Effects of corrosion inhibitors on biofilm physical characteristics and associated infection risk of legionella pneumophila
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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A study of the relationship between viability, culturability and virulence in environmental populations of Legionella pneumophila
… state. In order to study this phenomenon in Legionella pneumophila, a model hot water system was constructed to serve as a source of planktonic and biofilm cells. Both planktonic and biofilm L. pneumophila existed primarily as nonculturable cells. A portion of these nonculturable cells were …
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