Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Left-right patterning"”.
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The role of Cited2 in left-right patterning and placental development in the mouse
… One possibility is that the establishment of the left-right body axis that provide morphological cues for developing organs, like the heart, is perturbed in these mutant embryos. Cited2 is expressed in the relevant left-right patterning tissues such as the node and the lateral plate mesoderm. …
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Identifying Novel Causes of X-Linked Heterotaxy
… and abdominal organs due to errors in embryonic left-right patterning, affecting ~1 in 10,000 live births. These patients exhibit considerable phenotypic heterogeneity, with structural heart defects significantly contributing to poor outcomes. Variants in several genes can disrupt laterality, but …
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Transcriptional Profiling of Early Cardiac Development
… interest because it is during these stages that patterning of cardiac structure appears critical. Traditionally, studies of these early developmental processes have been conducted on chicken, fish, or frog embryos due to ease of manipulation. More recently, however, the wide availability of tools …
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Role of Xenopus Pitx3 during early development.
… we also studied the role of this gene in the left-right patterning and axis formation in Xenopus. Here, we report the cloning of a Xenopus homolog which encodes a conceptual protein of 292 amino acids and shows a high similarity in amino acid level to human and murine Pitx3. Early neurula …
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BMP Signaling through BMPR1A is Required for Establishment of Pancreatic Laterality
… forming mesothelial structure that accompanies leftward growth of the pancreas. Conversely, over expression of Bmp2 in the pre-pancreatic milieu does not result in defects in SMP formation or lateral growth of the pancreas. However, overexpression of Bmp2 in the pancreas epithelium resulted in …
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FGF signaling in specification of hESC-derived definitive endoderm
… that FGF2 acts in a restricted manner primarily patterning the ventral foregut endoderm into liver and lung, whereas FGF4 exhibits broad anteriorposterior and left-right patterning activities. Furthermore, whereas FGF2 is not required for ventral pancreas development an inductive role of FGF2 has …