Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 100 for “"Lectins"”.
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Biophysical Studies of Pathogen Recognition by C-Type Lectins
C-type lectins are a prominent class of pathogen recognition receptors in the innate immune system. The three pathogen recognition lectins studied in this thesis are the mannose binding protein (MBP), the dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) and the dendritic cell-specific …
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GLYCOMIMETIC LIGANDS TARGETING BACTERIAL LECTINS: RATIONAL DESIGN, SYNTHESIS AND BIOPHYSICAL EVALUATION
… colonization and infection. Many bacteria use lectins, which are carbohydrate-binding proteins, to recognize glycoconjugates on the surface of host cells and facilitate adhesion. These bacterial proteins represent an attractive target for designing antagonists that disrupt glycoconjugate-lectin …
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LECTINS FROM THE HORSESHOE CRAB, LIMULUS POLYPHEMUS, REACTIVE WITH BACTERIAL LIPOPOLYSACCHARIDE
<p>The Limulus serum is capable of precipitating various components of the lipopolysaccharide molecule from R mutants of Salmonella minnesota. Precipitation-inhibition studies using 2-keto-3-deoxyoctonate (KDO) have supported the hypothesis that this acidic residue is the immunodeterminant group in …
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Enterotoxin B Subunit Lectins as Adjuvants for Improvement of Mucosal Vaccine
<p>In comparison with whole organism vaccines, subunit vaccines may be safer for immunization but may lack sufficient immunogenicity to provide complete immunity to the pathogen. To resolve this problem, bacterial and plant enterotoxin B subunit adjuvants containing a variety of receptor-binding …
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VARIABILITY AND MODIFICATION OF THE LECTINS OF SOME MEMBERS OF THE PAPILIONOIDEAE
… study were to investigate the variability of lectins of leguminous plants, assessing differences between species, between cultivars of the same species and within the plant itself, and also the potential modification of such lectin activity. Three sources of material were investigated for …
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The Ligand and Function of the RegIII Family of Bactericidal C-Type Lectins
… screen revealed that expression of two C-type lectins, RegIIIbeta and RegIIIgamma , is strongly induced following intestinal colonization with resident microbes. Two features suggested that members of the RegIII family may have microbicidal functions. First, they are C-type lectin family …
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New insights into molecular recognition of epitopes related to MUC1 human mucin by lectins
… these two amino acids in terms of affinity to lectins. As a result, it is important to mention specifically the underlying amino acid in Tn antigen. We have also analyzed the role of flanking amino acids of Tn antigen in the peptide chain, getting surprising results in terms of affinity to …
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Detection and Capture of Nitrogen Fixing Bacteria From Soil and Roots Using Plant Specific Lectins
… This thesis aims to use plant root proteins, or lectins, to more rapidly recover viable diazotrophs that are likely to associate with crops. In this study, lectins, are used to recover bacteria from bulk soil by taking advantage of the binding relationship between lectins and bacterial cell …
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Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells
… the recognized sugars are usually called lectins. Mistletoe lectin isoform I (MLI), from Viscum album, is an example which has strong binding affinity for sialic acids especially α2,6 sialic acid.In the present study, mistletoe lectin isoform I chain B (MLB) was targeted through conducting …
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Cuticular Proteins of Hyalophora Cecropia: Characterization With Electrophoresis, Antibodies, and Lectins (Insect, Hydrophogicity, Metamorphosis, Glycoproteins, Avidin-Biotin)
… and by reactions with antibodies and lectins. As urea concentration in 2D gels was increased, some of the cuticular proteins from the larval dorsal abdomen decreased in mobility relative to the molecular weight standards. This decrease was found to be dependent on the pH and ionic …
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Carbohydrate and bacterial binding specificity of human intelectin-1
… and which must be cleared. Human soluble lectins are secreted carbohydrate-binding proteins that bind microbes by specific recognition of cell surface glycans. Many soluble lectins are important mucosal innate immune factors, as lectins binding to microbes can result in their clearance …
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Molecular characterization of soybean meal trypsin inhibitors and lectins as a basis for developing approaches to mitigate their anti-nutritional effects
Soybean is a crop that is widely eaten because of its nutritive properties. However, soybean cannot be consumed in its raw form because it contains anti-nutrients like trypsin inhibitors which bind to serine proteases (chymotrypsin, elastase and trypsin) and restrain their digestive functions …
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Dietary Plant Lectins May be an ‘Unknown Etiology’ in Parkinson’s Disease and Dietary Bioactive Compounds Affect Lifespan and Fat Storage Aspects of Caenorhabditis Elegans
… nervous system. Our hypothesis 1: dietary plant lectins might be responsible for the “unknown pathogen” causing PD. Pomegranate juice (PJ) have antioxidant and anti-obesity effects. Our hypothesis 2: PJ increases lifespan in C. elegans and reduces fat storage. Study 1: Post-feeding rhodamine or …
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Affinity purification of blood group A-active glycolipids on immobilized Helix pomatia lectin
… found in glycolipids, three GalNAc-specific lectins were selected to develop a lectin affinity chromatographic method for glycolipids. To circumvent the difficulty of working with micelles, the autoradiographic detection of ¹²⁵l-labeled lectins binding to glycolipids on thin-layer …
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SERS-based nanoparticle biodetection using carbohydrate-lectin interactions
… of a variety of carbohydrate-binding proteins (lectins) was measured via changes in the extinction profile, size and the SERS response of those particles. Nanoparticle aggregation was used for the sensitive detection of plant lectins, including the Concanavalin A and Jacalin lectin and also …
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