Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 195 for “"Lectin"”.
-
SELECTIVE GLYCOMIMETIC LIGANDS OF C-TYPE LECTIN RECEPTORS
C-type lectin receptors (CLRs) are calcium-dependent proteins dedicated to sensing glycan motifs, including those expressed on the surface of invading pathogens. Although this recognition event usually leads to induction of an immune response, many pathogens have evolved mechanisms to exploit …
-
SERS-based nanoparticle biodetection using carbohydrate-lectin interactions
… of a variety of carbohydrate-binding proteins (lectins) was measured via changes in the extinction profile, size and the SERS response of those particles. Nanoparticle aggregation was used for the sensitive detection of plant lectins, including the Concanavalin A and Jacalin lectin and also …
-
Tracing The Origin Of A Lectin-like Antifreeze Protein
Type II antifreeze proteins (AFPs) are C-type lectin homologs found in three lineages of teleost fish (Cottidae, Clupeiformes and Osmeriformes). Previous work demonstrated that the AFP gene was horizontally transferred from the Atlantic herring to the smelt, and also showed that the herring is not …
-
The functional characterisation of the C-type lectin : Clecsf8
Clecsf8 is a poorly characterised member of the "Dectin-2 cluster" and was originally thought to be expressed exclusively by macrophages. In this study it was demonstrated that Clecsf8 is primarily expressed by peripheral blood neutrophils and monocytes.
-
Molecular Basis of Peptidoglycan Recognition by a Bactericidal Gut Lectin
… proteins are novel in that they are C-type lectins that directly kill Gram-positive bacteria and thus play a vital role in antimicrobial protection of the mammalian gut. RegIII proteins bind their bacterial targets via interactions with cell wall peptidoglycan, but lack the canonical …
-
The characterization of a novel C-type lectin-like receptor, CLEC9A
Includes abstract. Includes bibliographical references (leaves 147-161).
-
Interpretable Supervised Learning and Graph-Based Optimization for Glycan-Lectin Binding
… interactions with glycan-binding proteins called lectins. As a result, there is particular interest in the design of highly specific glycan binders to critical lectins such as dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN). However, insufficient knowledge of the binding specificity …
-
Targeted expression of the anti-HIV microbicide lectin griffithsin in maize and tobacco
… neutralising antibodies and peptide lectins- lend themselves to production in plants (De Muynck et al., 2010; Matoba et al., 2010; Sexton et al. 2006; O’Keefe et al., 2009). One of these lectins, namely Griffithsin (GRFT) was isolated from the blue green algae Griffithsia and is being …
-
Engineering of the RTB Lectin as a Carrier Platform for Proteins and Antigens
… is being given to the class of proteins known as lectins to deliver therapeutic and antigenic proteins to the interiors of cells. Lectins bind to but do not modify sugars, and provide an efficient route to endocytosis. The galactose/N-acetyl-galactosamine specific lectin ricin B-chain (RTB) is …
-
Genetic and Immunological Analyses of a Brucella abortus Protein Exhibiting Lectin-like Properties
… assay revealed that the 16 kDa protein exhibits lectin-like properties. Preliminary studies using hemagglutination inhibition identified mannose as a possible sugar to which the 16 kDa protein can interact. The lectin-like properties exhibited by the 16 kDa protein appears to influence smooth …
-
Affinity purification of blood group A-active glycolipids on immobilized Helix pomatia lectin
Lectin affinity chromatography has proven to be a powerful method to separate oligosaccharides based on their stereochemical structures. This technique has not been used for the separation of glycolipids since mixtures of these compounds form micelles in aqueous solution. Since …
-
Regulation of C-type lectin-like receptors dectin-1 and CLEC-2 by tetraspanins
… recently shown to negatively regulate the C-type lectin-like receptor dectin-1, which is essential for innate immune responses to fungal pathogens. The aim of this thesis was to firstly develop a cell line model system to investigate the mechanism by which tetraspanins inhibit dectin-1, and to …
-
Identification of tumour-associated gycoproteins recognised by the lectin from Helix pomatia in breast cancer
… HPA binding partners in cancer, as the lectin has been shown to identify glycosylation changes in cancers arising from the epithelia, from patients with poor prognosis. Identifying the HPA binding epitopes associated with a malignant phenotype may be useful for prognostication and may …
-
Deciphering The C-Type Lectin Receptor Signaling Pathway In Macrophages In Response to Candida Albicans
… individuals. Dectin-2, a C-type lectin receptor, is required for recognition of <em>C. albicans </em>by innate immune cells and is required for initiation of the anti-fungal immune response. We set out to identify components of the intracellular signaling cascade downstream of …
-
Interaction of the porcine reproductive and respiratory syndrome virus with the macrophage-specific lectin sialoadhesin
… Chapter 1 of this dissertation discusses glycan-lectin interactions in virus biology and gives an introduction on PRRSV. The first section of this chapter reflects on glycosylation of cells and viruses and explores glycan-lectin interactions in the context of viral infections. A brief …
Page 1 of 10