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Showing 1 to 2 of 2 for “"Leberresektion"”.
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Role of the IKK complex during liver regeneration
The transcription factor NF-kB is essential for liver homeostasis. The IKK complex (composed by two catalytic subunits IKK1 and IKK2 and a regulatory subunit Nemo) tightly regulates NF-kB activity. In the present work, we modulated NF-kB activity in the liver by using hepatocyte-specific IKK2 …
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Molecular analysis of the role of Caspase-8 during liver regeneration and tumorigenesis
Binding of the cytokine TNF-alpha to TNF-Receptor 1 mediates pleiotropic effects via two different signaling complexes. Complex-I triggers activation of NF-kappaB and activation of c-Jun N-terminal kinases (JNK) leading to inflammation and/ or cell proliferation, whereas complex-II induces …