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Showing 1 to 17 of 17 for “"Leberfibrose"”.
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Etablierung adenoviraler Genexpression zum antifibrotischen Einsatz bei der Leberfibrose
Liver fibrosis results from an imbalance between synthesis and degradation of extracellular matrix components due to a variety of deseases such as virus hepatitis, alcoholic abuse or metabolic dysfunction. The cytokine TGF-ß plays an important role in so far it interferes during hepatic injury with …
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Molekulares Targeting von Hepatischen Sternzellen zur Therapie der Leberfibrose
Chronic injury of the liver leads to liver fibrosis by the activation of hepatic stellate cells (HSC) and in final consequence to liver cirrhosis. Removal of activated HSC by apoptosis precedes fibrosis resolution in experimental induced fibrosis. Thus the purpose of this work was to induce …
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TGF-β Signaltransduktion in der experimentell induzierten Leberfibrose durch die Gallengangsligatur bei der Ratte
Background/Aims: Profibrogenic TGF-beta signaling in hepatic stellate cells is modulated during transdifferentiation. Strategies to abrogate TGF-beta effects provide promising antifibrotic results, however, in vivo data regarding Smad activation during fibrogenesis are scarce. Methods: Here, liver …
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Expression, Reinigung und therapeutischer Einsatz eines löslichen TGF-[beta]-Typ-II-Rezeptors in der experimentell induzierten Leberfibrose
The aim of this work was the production and testing of a soluble tgf-beta type II receptor as a pure protein in the therapy of the experimental induced liverfibrosis. Tgf-beta is as a mastercytocine responsible for the transdifferentiation of hepatic stellate cells to myofiborblasts, the key-event …
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Assoziation zwischen vier Polymorphismen des menschlichen Transforming-Growth-Factor-beta1-Gens und der zeitlichen Progression der posthepatitischen Leberfibrose
Background: The objective of the present study was to elucidate possible relationships between four polymorphisms of the TGF-beta1 gene (-800G>A; -509C>T; Leu10Pro; Arg25Pro) and stage, histological activity grade and progression rate (METAVIR-score) of liver fibrosis. Methods: Three study groups, …
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Zur analytischen und medizinischen Bewertung der nicht-invasiven multiparametrischen Bestimmung der Leberfibrose und -fibrogenese am Beispiel von Fibrotest und Actitest
BACKGROUND: Determining the stage and grade of liver- fibrosis by liver biopsy is important in managing patients with liver diseases causing fibrosis. Commercially Biopredictive provides per internet non- invasive analytical tests (Fibrotest, Actitest) for diagnosis of liver- fibrosis. AIMS: To …
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Einfluss von Transforming Growth Factor-beta1 (TGF-[beta]1) Genpolymorphismen auf die Hepatitis-C-induzierte Leberfibrose in vivo und Modulation der TGF-[beta]1-Synthese, Prozessierung und Sekretion durch die Serin-Protease Furin, das latent TGF-[beta] binding protein-1 und Polymorphismen der TGF-[beta]1-Signalsequenz in vitro
In the first part of this thesis, the influence of TGF-beta1 polymorphisms at position –509, codon 10, codon 25 and codon 263 on hepatitis C induced liver fibrosis was analysed. For that purpose, liver needle biopsies from 430 patients suffering from chronic hepatitis C infection were scored for …
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Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts
… von zentraler Bedeutung für die Pathogenese der Leberfibrose. Das IGF-System bestehend aus den Insulin-ähnlichen Wachstumsfaktoren I und II (IGF-I, -II), ihren Rezeptoren (IGF-I-Rezeptor, IGF-IR; IGF-II/Mannose-6-Phosphat-Rezeptor, IGF-II/M6-PR) und sechs hochaffinen IGF-Bindungsproteinen …
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Unterschiede in der TGF-[beta]-vermittelten Signaltransduktion in aktivierten hepatischen Sternzellen unterhalb der Smad2-Phosphorylierung
TGF-beta is a multifunctional cytokine, that regulates cell proliferation, differentiation, and extracellular matrix production. A profibrogenic role of TGF-beta is postulated, but pathways targeting the TGF-beta response to specific gene activities involved in phenotypic changes of hepatic …
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Role of monocyte subsets in chronic liver injury and liver fibrosis
Monocytes are key players of the innate immune system and crucially modulate tissue inflammation after injury. Mammalian monocytes consist of two principle subsets that display different chemokine receptor expression levels. In humans, the classical monocyte CD14++CD16- subset expresses CCR2, CD64, …
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Morphological characterization of liver fibrogenesis in animal models with genetically modulated TGF-beta signal transduction
Production of fibrous scar tissue in the liver is a normal response to injuries. In fibrosis this healing process is disturbed. Liver fibrosis is defined as the accumulation this fibrous scar tissue in the liver. After hepatocyte damage due to e.g. viral infection, heavy alcohol consumption, toxins …
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Induzierter Zelltod von transdifferenzierten hepatischen Sternzellen (Myofibroblasten) auf der Basis des Thymidinkinase-Ganciclovir-Systems
In the current study the thymidine kinase / ganciclovir-system was used to develop a prophylaxis in oder to prevent liver fibrogenesis. The intention was to eliminate activated hepatic stellate cells (HSC), those cells which became proliferative, fibrogenetic and contractile because of liver …
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Kryokonservierung von hepatischen Sternzellen der Ratte
In this work a protocoll for the cryopreservation of rat hepatic stellate cells was developed. Isolated HSC of the rat are used as a model of liver fibrogenesis. Many proceedings are studied on this cells, for example the biotransformation, the gene expression, the effect of pharmaceuticals, …
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Untersuchung von antigenpräsentierenden Funktionen bei kultivierten hepatischen Sternzellen und transdifferenzierenden Myofibroblasten der Ratte
Studies with liver cells in mice have shown that even cells that are not directly attributed to the immune system can play an antigen-presenting function. The aim of this study was to investigate the behavior of these antigen-presenting hepatic stellate cells (HSC) in rat. Also changes of the …