Global ETD Search
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Showing 1 to 3 of 3 for “"Leader cell"”.
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The mechanisms underlying mechanical cell competition and leader cell migration in mammalian epithelia
Cell competition is a form of cell-cell signalling that results in the elimination of less fit cells from a tissue by their fitter counterparts. I take advantage of an established in vitro model of cell competition using Madin-Darby canine kidney (MDCK) cells to shed insight into the molecular …
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Investigating the mechanisms of cell competition in mammals using in vitro systems
Cell competition leads to elimination of a viable cell population, by fitter cells. Despite over forty years of research, the molecular mechanisms of competition in mammals are poorly understood. During my PhD I have investigated the mechanisms of competition by exploring an established mammalian …
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A Suspended Fiber Network Platform for the Investigation of Single and Collective Cell Behavior
Cells interact with their immediate fibrous extracellular matrix (ECM); alignment of which has been shown influence metastasis. Specifically, intra-vital imaging studies on cell invasion from tumor-matrix interface and wounds along aligned fibers describe invasion to occur as singular leader (tip) …