Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 587 for “"Lc-ms"”.
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Entwicklung von Screeningverfahren für Arzneistoffe und Metaboliten mittels LC-MS und LC-MS/MS
Zunächst wurde ein LC-MS Screeningverfahren weiterentwickelt basierend auf einer bereits existierenden Screening Methode auf körperfremde Substanzen mit einer ESI-CID Massenspektrenbibliothek. Diese Bibliothek musste neu erstellt werden wegen Umstellung von der Software-Version eines Macintosh …
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Protein LC-MS Using Slip Flow Chromatography
… variants and post-translational modifications (PTMs). PTM levels of histones are known to correlate with different stages of cancer. Due to the lack of resolution on intact histone separations, conventional methods for histone analysis require time-consuming digestion, which often leads to the …
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Studium nových syntetických drog metodou LC/MS/MS
… vybrán mefedron včetně jeho metabolitů metodou LC-MS/MS. Byl studován standard, negativní moč s přídavkem mefedronu a reálný vzorek moči potkana, kterému byl podán mefedron. Ve vzorku moči byl detekován mefedron a některé jeho metabolity. Získané informace o zkoumaných látkách mohou být následně …
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Evaluation of a particle beam interface for LC/MS
… performance of a Hewlett Packard Particle Beam LC/MS interface is evaluated using EPA appendix VIII and IX compounds. The behavior of these priority pollutants in the interface could determine its feasibility as a future EPA certified technique. The evaluation process consists of studies to …
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Innleiðing einnar mæliaðferðar á LC-MS/MS fyrir átján sterahormón
… liquid chromatography tandem mass spectrometry (LC- MS/MS). Today LC-MS/MS is considered a gold standard for steroid hormone measurements. LC- MS/MS technique is both quantitative and qualitative and able to quantitate very low concentrations of analytes and determine complex molecule structures. …
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Computational Analysis of LC-MS/MS Data for Metabolite Identification
Metabolomics aims at the detection and quantitation of metabolites within a biological system. As the most direct representation of phenotypic changes, metabolomics is an important component in system biology research. Recent development on high-resolution, high-accuracy mass spectrometers enables …
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Characterization of Glycans Derived from Biological Samples Using LC-MS/MS
… prevalent post-translational modifications (PTMs) is protein glycosylation, which enhances several biological functions, such as protein stability, localization, cellular communication, inflammation, immune responses, and host-pathogen interactions. Unusual protein glycosylation has been linked …
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Bayesian Alignment Model for Analysis of LC-MS-based Omic Data
… chromatography coupled with mass spectrometry (LC-MS) has been widely used in various omic studies for biomarker discovery. Appropriate LC-MS data preprocessing steps are needed to detect true differences between biological groups. Retention time alignment is one of the most important yet …
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Resíduos de glyphosate em grãos de café determinados por LC- MS/MS
… acoplada à espectrometria de massas tandem (LC-MS/MS) (Capítulo 1). Em sequência, esse método foi aplicado em um estudo a campo para avaliar a possível contaminação de grãos de café verde após a aplicação do glyphosate em diferentes estágios de desenvolvimento da cultura do café (Capítulo 2). …
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Effect of mobile phase additives on linearity in particle beam lc/ms
… Beam Liquid Chromatography/Mass Spectrometry (PB LC/MS) has been shown to be useful for the identification and confirmation of nonvolatile and thermally labile compounds, evidence has been reported of response nonlinearity at low concentrations. Addition of a mobile phase additive to the HPLC …
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Novel Preprocessing and Normalization Methods for Analysis of GC/LC-MS Data
… coupled with mass spectrometry (GC/LC-MS). Normalization is desired prior to subsequent statistical analysis to adjust variabilities in ion intensities that are not caused by biological differences. There are different sources of experimental bias including variabilities in sample …
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Computational Tools to Expand the Coverage of Metabolite Profiling via LC-MS/MS
… of the common metabolite profiling technologies, LC-MS/MS, and takes two steps to expand the coverage of current metabolite profiling experiments.</p><p>First, a method to enable collection of MS/MS data from a greater portion of the detected ions is presented. This is done by collecting …
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The Investigation and Application of Alternative Strategies for LC/MS based Bioanalytical Research
… two unique approaches in the application of LC/MS for the analysis of drugs and endogenous compounds in biofluids. First, the use of basic aqueous mobile phases in conjunction with both methanol and acetonitrile by LC/MS operating in electrospray positive ionization mode was investigated. …
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classCleaner: A Quantitative Method for Validating Peptide Identification in LC-MS/MS Workflows
… liquid chromatography-tandem mass spectrometry (LC-MS/MS) shotgun proteomics infers the peptide sequence of each measurement, there is inherent uncertainty in the identity of each peptide and its originating protein. Removing misidentified peptides can improve the accuracy and power of downstream …
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A Data Attribution-Based Approach to Model Diagnosis in LC-MS/MS Structure Prediction
… liquid chromatography tandem mass spectrometry (LC-MS/MS) is a challenging task with far-reaching implications in many areas such as drug discovery, environmental science and metabolism research. Yet, despite its importance and significant efforts to develop machine learning (ML) models for the …
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