Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Lbx1"”.
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dB2 neuron dysfunction causes congenital hypoventilation
… Mutations in the transcription factors PHOX2B or LBX1 correlate with congenital central hypoventilation disorders, but the dysfunctional neurons responsible for these respiratory diseases are unknown. During my studies, I investigated the function of a molecular defined neural type of medullary …
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Prdm13, a Direct Downstream Target of Ptf1a, Regulates the Balance of Gabaergic Neurons versus Glutamatergic Neurons in the Dorsal Spinal Cord
… known that Tlx1/3 normally blocks the HD factor Lbx1 that is also involved in GABAergic neuronal specification. Taken together, Prdm13 is a direct target of Ptf1a and is required to suppress the glutamatergic neuronal gene program in GABAergic neurons in the dorsal spinal cord. Therefore, Prdm13 …
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Detailed analysis of Lmx1b expression in multiple organs and its role in dorso-ventral patterning with emphasis on myogenic precursor cells
Lmx1b belongs to a family of LIM homeodomain transcription factors expressed in multiple organs. Targeted disruption of Lmx1b results in ventralization of the limbs, skeletal, brain, kidney and ocular defects which resembles the corresponding human Nail-Patella Syndrome (NPS) (Chen et al. 1998a). …