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Showing 1 to 1 of 1 for “"Lats kinase inhibitor"”.

  1. Small-Molecule Activation of Yap for Inner-Ear Regeneration – and Beyond

    … identified a potent, non-toxic, and reversible inhibitor of Hippo signaling. An ATP-competitive inhibitor of Lats kinases, the compound causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids. The compound …

    rockefeller Repository record for Small-Molecule Activation of Yap for Inner-Ear Regeneration – and Beyond (opens in a new tab)