Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Lateral Habenula"”.
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The Behavioral Effects of Temporary Inactivation of the Lateral Habenula on Free Feeding
… purpose of the present study was to assess the lateral habenula as a candidate region, due to its connectivity to midbrain reward circuitry, sensitivity to metabolic signaling, and pronounced role in drug-related motivated behaviors. Here I report that inactivation of the LHb attenuated feeding …
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A Role for the Lateral Habenula in a Delay Based Decision Making Test
The lateral habenula (LHb) is thought to provide an aversive or anti-reward signal in the mammalian brain under Pavlovian conditions. However, recent evidence suggests that the LHb also controls more complex decision-making during appetitive behaviors, since LHb disruption impairs hippocampal …
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Characterization of genetically distinct neuronal subtypes in the lateral habenula using Cre mouse lines
The lateral habenula (LHb) is a bilateral brain structure implicated in action selection, reward processing, and motivation. The LHb projects to the ventral tegmental area (VTA) and dorsal raphe nucleus (DNR), and is thus involved in both dopaminergic and serotonergic pathways. Recent single-cell …
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Haloperidol-Environment Interaction Modulates Expression of c-Fos Proteins in the Basal Ganglia in Rats
… ventral hippocampus, ventral tegmental area or lateral habenula. The numbers of rats in the Saline, Paired, and Unpaired groups were: 9, 10, and 6 for the piriform cortex, dorsal striatum, nucleus accumbens and ventral pallidum; 5, 10, and 5 for the ventral hippocampus; 5, 5, and 5 for the …
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Network mechanisms underlying susceptibility to helplessness and response to the antidepressant fluoxetine
… Holtzman strain. Finally, hypermetabolism of the lateral habenula and a less interactive prefrontal-limbic cortex were identified in subjects with higher susceptibility towards helplessness within the Holtzman strain. Similar findings have been reported with other depression animal models and …
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Neural Computation Through Synaptic Dynamics in Serotonergic Networks
… be activated by long-range excitatory input from lateral habenula, representing threat signals. Targeted physiology and modeling revealed that these recurrent short-term facilitation features generated paradoxical excitation-driven inhibition in response to high-frequency habenula input. These …
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Role of Rostromedial Tegmental Nucleus Afferents in Symptoms of Withdrawal from Chronic Ethanol Exposure
… increased in both the RMTg and RMTg-projecting lateral habenula (LHb) neurons during acute withdrawal. In vivo chemogenetic inhibition of this circuit attenuated withdrawal-induced thermal hyperalgesia in a sex-dependent manner. Collectively, these data suggest that RMTg-projecting LHb neurons …
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Modificazioni neuronali nella via abenulo-mesencefalica durante l’astinenza da Δ9-tetraidrocannabinolo
… eventually lead to relapse into drug taking. The lateral habenula (LHb) exerts a negative control over the VTA via a γ-aminobutyric acid (GABA) structure, the rostromedial tegmental nucleus (RMTg), encoding aversion-related stimuli. In fact, both RMTg and LHb neurons are excited by …
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Monoaminergic Regulation of MeCP2 Phosphorylation in Mouse Models of Psychiatric Disease
… acute imipramine treatment induces pMeCP2 in the lateral habenula (LHb), a brain region involved in the behavioral response to stress and reward. Together, these data implicate a novel role for pMeCP2 in depression-like behavior and the behavioral response to chronic antidepressant treatment.</p>