Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Latency-associated"”.
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Pseudorabies Virus Latency Associated Transcript Gene: Expression, Regulation, and Role in the Establishment of Latency in Swine
… presented in Chapter 1 demonstrate that the PrV latency associated transcripts (LAT) gene is also active during an in vitro productive infection. Three polyadenylated [poly(A)] RNAs (about 1.0, 2.0, and 8.0 kb) made during a lytic in vitroinfection share similar physical properties with the in …
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Investigating and exploiting the latency-associated expression of the human cytomegalovirus gene US28 in early myeloid lineage cells.
… the mechanisms by which HCMV maintains latency and reactivates, a better understanding is essential towards the aim of targeting and killing latently infected cells. In this thesis, I will present evidence that the HCMV-encoded chemokine receptor homologue US28, which is expressed during …
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Development of novel T cell assays and assessment of immune recognition to latency associated M.tuberculosis-specific antigens Rv2660 and Rv2659
… T cell responses to antigens that have been associated with M.tb latency. Rv2660 and Rv2659 were investigated, as these antigens are candidate antigens for a postinfection vaccine based on findings from in vitro models of M.tb suggesting preferential expression during latency in vivo. No …
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Characterisation of T cell responses to proteins expressed during Human Cytomegalovirus latency
… view was that viral gene expression during latency was largely absent, thus facilitating the avoidance of immune detection. However, it has now been established that viral activity in latency is far from quiescent, and the expression of a number of viral genes is known to occur. Therefore, …
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Investigating the Role of Human Cytomegalovirus Protein LUNA in Regulating Viral Gene Expression during Latency
… during latent infection grants insight into how latency is regulated and how it could be therapeutically targeted. To that end, this project has sought to evaluate the functional significance of one such viral gene termed LUNA in the context of latency. In models of experimental latent infection …
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A TOLL-LIKE RECEPTOR-INDUCIBLE AND B CELL-SPECIFIC ENHANCER REGULATES MURINE GAMMAHERPESVIRUS 68 LATENCY AND REACTIVATION
… Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV). MHV68, EBV, and KSHV are lymphotropic and are associated with a variety of lymphadenopathies, carcinomas, and lymphomas. B cells are the main latent reservoir of gammaherpesviruses. A central question is how B cell …
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Virus-Host Interactions during Epstein-Barr virus Latent Infection of B cells
… asymptomatic lifelong infection, EBV is associated with and the causative agent of several human malignancies, particularly in cases of immune suppression. There is extensive interplay between the virus and normal host factors and processes that are critical for maintenance of a …
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Novel markers for human T regulatory cells in healthy donors and cancer patients
… in which the mature TGF-β protein is bound to latency-associated peptide (LAP) that binds to Glycoprotein A Repetitions Predominant (GARP). Some FoxP3+ Tregs express Helios, a member of the Ikaros transcription factor family. The purpose of this study is to identify which of FoxP3+/-Helios+/- …
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Ex Vivo Induction of Human Regulatory T Cells
… expression of CD36 and the TGF-beta related latency associated peptide, LAP. We termed this unique cellular subset CD14+CD36HI monocytes, and further demonstrated their expression of the LAP-TGF-beta binding transmembrane molecule GARP, functioning to tether TGF-beta to the cell surface. …
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Cloud-aided wireless systems: communications and radar applications
… parameters, which determine the energy and latency associated with the mobile-cloud communication, motivates the inter-layer optimization of fine-grained task offloading across both layers. This problem is modeled by using application call graphs, and the joint optimization of …
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Untersuchungen zur TGF-[beta]1-Expression und -Bioverfügbarkeit bei der Leberfibrogenese
… latent molecule complexed either only with the “latency associated peptide” (LAP) or with LAP and the “latent TGF-Beta binding protein” (LTBP). Activated hepatic stellate cells (HSC) and their fully transdifferentiated phenotype, the myofibroblasts (MFB), are considered to be the major source of …
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The impact of EPHA2 polymorphism on KSHV infectivity and KS prevalence among HIV/AIDS patients in South Africa
… and mortality. The oncogenic Kaposi's Sarcoma-associated herpes virus (KSHV) is the etiological agent of KS. Although KSHV seroprevalence in sub-Saharan Africa is high, not all AIDS patients develop KS, suggesting that host genetic factors contribute to susceptibility. The infection mechanism …
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NEU Insights and Development of Potential Therapeutics for Pulmonary Fibrosis
… pulmonary fibrosis mouse model studies. Fibrosis-associated signals such as transforming growth factor-β1 (TGF-β1) and interleukin (IL)-6 upregulate NEU3 in a variety of human lung cells. Conversely, recombinant human NEU3 upregulates extracellular accumulation of active TGF-β1 and upregulates …
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Keratose Hydrogels Promote Vascular Smooth Muscle Differentiation from c-kit+ Human Cardiac Stem Cells: Underlying Mechanism and Therapeutic Potential
… growth factor beta 1 (TGF-β1) and its associated peptides for hCSCs cultured on KOS hydrogels, tissue culture polystyrene, and collagen hydrogels. A review of VSMC differentiation signaling pathways informed our decision to investigate the role of TGF-β1 in VSMC differentiation. Results …