Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 500 for “"Late-stage"”.
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Late stage 18F-difluoromethylation of N-heteroaromatics
We herein describe a new methodology for the late stage addition of CHF18F to N-heteroaromatics for PET imaging. This methodology proceeds via C-H activation, under flow photoredox conditions. The 18F-difluoromethylation relies on the use of a new 18F-difluoromethylating reagent derived from the …
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Need experienced by persons with late stage aids
… of the special needs expressed by persons with late stage AIDS in the Richards Bay area. A phenomenological research design and methods were employed to impose rigour on this event. Once the needs of persons with late stage AIDS had been made explicit, these were collated with services rendered …
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Electrochemically-Enabled Late-Stage Peptide C-terminal Modifications
… as a strong impetus for the exploration of late-stage peptide C-terminal modification strategies, particularly those which enable direct functionalization of the native C-terminal carboxylate motif. Considering the discrepancy between the enormous potential of electrochemistry and the …
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Electrochemically-Enabled Late-Stage Peptide C-terminal Modifications
… as a strong impetus for the exploration of late-stage peptide C-terminal modification strategies, particularly those which enable direct functionalization of the native C-terminal carboxylate motif. Considering the discrepancy between the enormous potential of electrochemistry and the …
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Planning And Interpretation Of Late Stage Functionalisation Reactions
… drug candidates in a fast and efficient manner. Late stage functionalisation (LSF) is poised to accelerate the process by making chemical synthesis modular so most of the molecules are assembled via standard protocols. Predicting the major reaction site is not straightforward due to multitude of …
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Late stage oxidative C(sp3)–H alkylation and arylation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Illness Perceptions of Patients with Late-Stage Cancer and Their Partners
As treatments improve and patients with late-stage cancer live longer, it is important to examine factors associated with their psychological adjustment and illness-related behaviors. The current studies used the Common-sense Model of Self-regulation (Leventhal, Brissette, & Leventhal, 2003) to …
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Investigating late stage biopharmaceutical product loss using novel analytical and process technology
… marketplace) and are therefore tightly regulated. This thesis is intended to explore the problem of protein particles through two main avenues: meeting current regulatory criteria and influencing future regulation. Process changes, analytical characterization, and organizational improvements …
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Early and Late Stage Mechanisms for Vocalization Processing in the Human Auditory System
… most basic acoustic features of these sounds; later elements may show categorically-selective response patterns that represent high-level semantic organization of different classes of vocalizations. A combination of functional magnetic resonance imaging and electrophysiological studies were …
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Late-stage C(sp3)–H hydroxylation, amination, and methylation in nitrogen-containing molecules
… have been demonstrated, but the hydroxylated intermediates are by nature more hyperconjugatively activated than the substrates and promote overoxidation, thus requiring reduction before further derivatization. In this dissertation, I describe new methods that address these issues and …
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Synthesis And Á-Stereoselective Sialylation Of Kdn And Late Stage Modification Of Neuraminic Acid Sialosides
… AND á-STEREOSELECTIVE SIALYLATION OF KDN AND LATE STAGE MODIFICATIONS OF NEURAMINIC ACID SIALOSIDES</p> <p>by</p> <p>CHANDRA SEKHAR NAVULURI</p> <p>December 2012</p> <p>Advisor: Prof. David Crich</p> <p>Major: Chemistry</p> <p>Degree: Doctor of Philosophy</p> <p>Keto deoxy nonulosonic acid has …
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Mechanisms underlying Leishmania parasites survival and dissemination at late stage of infection in human macrophages
… of reliable experimental models to study this stage of host-parasite interaction. This research aims to elucidate the mechanism behind cell-tocell spreading of Leishmania in vitro. A link between host cell apoptosis and Leishmania propagation was initially established by determining the effect …
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Nidogen-1 and Nidogen-2 in healthy human cartilage and in late-stage osteoarthritis cartilage
Einleitung: Ziel dieser Arbeit war die Untersuchung des Vorkommens und der Funktionen von Nidogen-1 und Nidogen-2 in gesundem humanem Knorpel und in den späten Stadien der Osteoarthritis. Methoden: Die Lokalisierung und Quantifizierung beider Nidogene im Knorpel, sowohl auf Protein als auch auf …
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An exploration of the "feeding partnership" between patients with late stage dementia and nursing staff
… of feeding partnerships between patients with late stage dementia and nursing staff. Twelve video dyads, consisting of four female patients and three members of their nursing team, were recorded during feeding. All twelve videos were made during the midday meal, within the normal nursing …
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Socio-spatial inequalities in late-stage cancer diagnosis in Illinois: spatiotemporal trends and methodological challenges
… effects of social and spatial inequalities on late-stage diagnosis of colorectal and breast cancer, and it addresses several methodological challenges surrounding the use of ZIP codes as a study unit in analyzing late-stage cancer at diagnosis. Given that my dissertation follows the …
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Hematocrit, hematocrit Regulation and its effect on oxygen consumption in the late stage chicken embryo (Gallus domesticus).
… the ability of chicken embryos at day 15 to regulate hematocrit, they were subjected to either repeated saline injections (5% of total blood volume) or repeated blood removal (5% of total blood volume). Embryos showed an ability to maintain hematocrit (~20%) despite blood volume increases up to …
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Mechanisms of late-stage rift deformation: evidence from new 3D seismic data over the West Iberia margin
… be the result of gravity-driven sliding during late-stage extension. After large-scale extension of continental crustal blocks, further extensional creep caused small-scale normal faulting of the pre-tectonic sediment in the north.
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Hybrid Brain-Tissue Based Model to Study the Role of Infiltrating Monocytes in Late Stage Huntington's Disease
… (HD) is an inherited, progressive, fatal, and late-onset neurodegenerative disorder. Its neuropathogenesis is characterized by selective loss of medium spiny neurons (MSNs) in the striatum and cortical neurons in the cortex. It is caused by an expansion of CAG repeats in the exon-1 of IT-15 …
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Conformationally-Controlled Late-Stage Modifications for SAR Studies of the C-3-Glcp Moiety of Ipomoeassin F
… studies of the tigloyl moiety possible. The late-stage conformationally-controlled highly regio-selective esterification allowed for the completion of ipomoeassin F and other tigloyl modified analogs. The in-house cytotoxicity data conveyed that large aromatic modifications greatly reduced …
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