Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Lassa"”.
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Metagenomic investigation of co-infections of Ebola virus disease and Lassa fever patients
Sequencing followed by metagenomic analysis is an extremely promising method for broad, unbiased disease profiling of patients for disease surveillance and diagnosis. Here, we use two popular metagenomics tools in union, k-mer-based Kraken with reads and BLAST- and LCAbased MEGAN with assembled …
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Pichinde virus infection of outbred Hartley guinea pigs and mice as small animal models of human Lassa fever
… in Africa and South America, including Lassa virus that causes Lassa fever in several countries in west Africa. There are currently no vaccines and very limited therapeutics available for Lassa fever. There are also several under-addressed complications of Lassa fever such as high infant …
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Elucidating the Immunogenicity and Protective Immune Response of a Trivalent Vaccine for Sudan Ebola, Marburg, and Lassa Fever Viruses
Sudan Ebola (SUDV), Marburg (MARV), and Lassa fever (LASV) viruses cause acute, severe haemorrhagic fevers resulting in high morbidity and mortality in overlapping regions of Africa. Despite millions of individuals in Africa being at risk of contracting an infection from one of these viruses, …
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ANIMAL MODELS FOR BEHAVIORAL CHANGES OR HEARING LOSS UPON ACUTE VIRUS INFECTIONS
… Sensorineural hearing loss is detected in 25% of Lassa fever patients and up to 90% of encephalitic alphavirus infections result in severe behavioral changes. Well-established murine models are available to study each of these viruses’ initial infection, including the wild-type C57BL/6 model of …
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Learning from pre-pandemic data to forecast viral antibody escape
… viruses with pandemic potential such as Lassa and Nipah. We provide continually updated escape scores for all current strains of SARS-CoV-2 and predict likely additional mutations to forecast emerging strains as a tool for ongoing vaccine development (evescape.org).
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Computational investigation of pathogen evolution
… an epidemic. I then (2) use changes in the Lassa genome to estimate the time that the pathogen has been circulating in Nigeria and in Sierra Leone, and to pinpoint sites that have recurrent, independent mutations that may be markers for lineage-specific selection. I (3) develop a method to …
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Medical Engineering and Medical Physics: Metagenomic Sequencing for Viral Diagnostics and Discovery
… in patient cohorts with primary HIV and Lassa infection. Metagenomic sequencing can also be utilized to perform large scale screening for the directed evolution of viral vectors. Adeno-associated virus (AAV) is a non-pathogenic virus that infects humans and commonly used as a vector for …
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Using the host immune response to hemorrhagic fever Viruses to understand pathogenesis and improve diagnostics
… of expression of macaques infected with either Lassa virus or Marburg virus, two related hemorrhagic fever viruses. I identified a set of genes that quickly become upregulated after a viral infection and remain highly expressed throughout the entire disease course, irrespective of the specific …
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Learning from pre-pandemic data to design and test future-proof therapeutics
… viruses with pandemic potential such as Lassa and Nipah. We investigate both alignment-based and protein language models to explore the best model of mutation effects across pandemic-threat viral families. We demonstrate the utility of EVEscape in three critical applications: (1) …
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Countermeasures Against Viral Hemorrhagic Fevers
… mouse, ticks, and mosquitoes. Ebola, Marburg, Lassa, and Crimean-Congo viruses are known to spread from person to person contact. However, airborne transmission of VHFs is thought to be very rare (CDC, 1988, Baron RC, 1983). Transmission is more likely to happen late in infection when patients …
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The role of RNA structures in the evolution of respiratory RNA virus genomes.
… I repeated the analysis on Ebola Zaire and Lassa virus to determine if similar patterns are observed in zoonotic viruses. I found this not to be the case. Based on these observations, I propose a novel model for emerging and pandemic RNA virus adaptation and hypothesise that immune pressure …
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Cytokine patterns in a comparative model of arenavirus infection: Implications for virulence and control of viral replication
… Pichinde provides an animal model for human Lassa fever, a disease that affects 300,000 to 500,000 people a year in western Africa. Low passage Pichinde virus (P2) induces a mild disease with low viremia, while high passage Pichinde (P18) induces a severe disease with high viremia, ending in …
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Sphingomyelinases and Lysosomal Trafficking in Ebolavirus Entry
… common core virus encoated with either vii EBOV, Lassa virus (LASV), or Venezuelan Equine Encephalitis virus (VEEV) surface glycoproteins were incubated with cells treated with ASM inhibitors. EBOV GP pseudotyped viruses were more sensitive to ASM inhibition, suggesting a GP-specific role for ASM …
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From Sample to Answer: Innovations in sample processing and CRISPR-based diagnostics for enhanced clinical translation and field deployment
… disease threats, which has fueled the spread of Lassa, Ebola, SARS-CoV-2, and Zika virus in recent years. Globally, this diagnostic gap is particularly pronounced at the primary care or community level, an essential site for swift and effective response. Widespread, rapid, and user-friendly …