Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Large artery"”.
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Large Artery Stiffness: Genes and Pathways
… the genetic basis of aortic stiffness in a large repository of human donor aortas that had undergone ex vivo pulse wave velocity (PWV) phenotyping. The first part of this work sought to investigate the molecular basis of Loeys-Dietz type 4 syn- drome in a pedigree with multiple cases of …
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Effect of Nebivolol and Lifestyle Modification on Large Artery Stiffness in Middle-Aged and Older Hypertensive Adults
For more than half a century cardiovascular disease has been the leading cause of death in the United States. Aging, hypertension, and obesity are major risk factors for cardiovascular disease and clearly associated with arterial stiffness. Arterial stiffness generates higher afterloads and …
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The Effects of Weight Gain and Atorvastatin Treatment on Arterial Stiffness
… is characterized by a progressive stiffening of large elastic arteries in the cardiothoracic region. Importantly, large artery stiffness is an independent predictor of cardiovascular events and mortality in both healthy and diseased populations. The results of several studies suggest that …
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Inflammation and arterial stiffness
… the vessel wall. It is well known that increased large artery stiffness independently predicts the cardiovascular risk in a variety of populations. The identification of populations at higher risk of increased arterial stiffness and the knowledge of the mechanisms involved in arterial stiffening …
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Effects of Aerobic Exercise on Cognitive and Cerebrovascular Function in Hypertensive Adults
… hypertension exhibit similar increases in large artery stiffness and decreases in extracranial hemodynamic pulsatility during cognitive activity, indicating similar neurovascular coupling between groups. In conclusion, these data indicate that middle-aged adults with controlled-hypertension …
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Platelet Receptor Glycoprotein VI in Ischaemic Stroke
… as it not only implicates GPVI-dimer in the large-artery atherosclerotic stroke subtype, it suggests a key role in cardioembolic stroke, where fibrin, rather than collagen, is the key platelet ligand. We compared the platelet surface expression of GPVI-dimer in a control, pre-stroke atrial …
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The effect of single nucleotide polymorphisms of oxidative stress genes and low grade inflammation upon pulse wave contour analysis, a useful non invasive, intermediate vascular phenotype.
… arterial compliance in patients with coronary artery disease (Chapters 4,5 and 6). In healthy volunteers, free of cardiovascular disease whether a relationship existed between markers of low grade inflammation and arterial stiffness (Chapter 7). Chapter 3: The reproducibility of diastolic pulse …
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The Impact of Chronic E-Cigarette Use on Flow- Mediated Dilation Elicited by a Sustained Shear Stress Stimulus
… creating a transient increase in blood flow in a large artery and measuring the endothelial dependent dilation, this is known as reactive hyperemia flow-mediated dilation (RH-FMD). Three previous studies have assessed the impact of chronic e-cigarette use on human endothelial function all using …
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Vascular and metabolic profile of 5-year sustained hypertensive versus normotensive black South Africans
… microcirculation. The stiffness of the carotid artery is associated with cardiovascular events, like stroke, and all-cause mortality. Furthermore, carotid stiffness is independently associated with stroke, probably because stiffening of the carotid artery may lead to a higher pressure load on …
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Cardiovascular magnetic resonance characterisation of the phenotype of resistant uncontrolled hypertension
… Further, RUH patients had significantly lower large artery elasticity (12.5±4 vs 14.7±3.8ml/mmHgx100, p=0.08) and lower small artery elasticity (4.1±2.1 vs. 6.9±3.6ml/mmHgx100, p< 0.001). RUH patients also had a higher systemic vascular resistance (1754±418.4 vs. 1363±371.5dyneXsecXcm-5, …
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Epidemiology of stroke and its subtypes in Chinese populations
… Compared with other ischaemic subtypes: large artery atherosclerosis (LAA) strokes were associated with diabetes; cardioembolic (CE) strokes were associated with AF and IHD; small vessel disease (SVD) strokes or lacunar strokes were associated with hypertension and diabetes. Analyses of …
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The effect of metformin on vascular function and AMP-activated protein kinase activation in Type 2 diabetes
… improves vascular endothelial function and large artery stiffness in patients with Type 2 diabetes. In parallel, the thesis examines if metformin exerts its beneficial effects in patients with Type 2 diabetes in association with altered AMPK activity in human adipose. Finally, the thesis …
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Studies of vascular function in patients with heart failure and either preserved or reduced left ventricular systolic function
… LV diastolic dysfunction, or ‘LV stiffness’, and large artery stiffness, when compared with normal subjects and patients with systemic hypertension. This implies that the interaction between the left ventricle and the vasculature is dysfunctional and a potential cause of HF-PSF. Although there are …