Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Large Vessel"”.
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Development of an In-Vitro Tissue Engineered Blood Vessel Mimic Using Human Large Vessel Cell Sources
… and therapies. Specifically, in-vitro blood vessel mimics (BVM) have been developed to create a bench-top blood vessel model using human cells that can be used to test and evaluate vascular disease treatments and intravascular devices. Previous BVM work has used fat derived human …
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An Educational Module To Improve Pre-Hospital Stroke Assessment: Stroke Mimics And The Field Assessment Stroke Triage For Emergency Destination (fast-Ed) Scale
… With more stroke systems adopting a prehospital large vessel occlusion (LVO) stroke scale that includes bypass protocol, it is imperative that emergency medical service (EMS) personnel be educated on how to implement the scale, identify stroke mimics, and accurately determine the time of last …
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Expanding the evidence of endovascular treatment for acute ischemic stroke: patient–centered outcomes, population–level impact, and patients presenting with mild stroke symptoms
… circulation acute ischemic stroke due to large?vessel occlusion is the new standard of care resulting in reduced disability compared to medical treatment. Practice guidelines recommend the use of EVT but can only speak to the evidence provided by clinical trials and might not be …
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Expanding the evidence of endovascular treatment for acute ischemic stroke: patient–centered outcomes, population–level impact, and patients presenting with mild stroke symptoms
… circulation acute ischemic stroke due to large‐vessel occlusion is the new standard of care resulting in reduced disability compared to medical treatment. Practice guidelines recommend the use of EVT but can only speak to the evidence provided by clinical trials and might not be …
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Causes and consequences of lacunar stroke
… Lacunar stroke is part of the spectrum of small vessel disease (SVD) which also causes cognitive impairment and gait disturbance; together these lead to dementia, falls and disability. Current evidence suggests that SVD is caused by a separate aetiology from large vessel stroke, which may be …
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Diagnostic, prognostic and therapeutic considerations in primary pulmonary hypertension
… study on patients with PPH and chronic large vessel thromboembolic pulmonary hypertension (TPH) seen at Groote Schuur Hospital between 1957 and 1985 in an attempt to: 1. Establish the diagnostic and prognostic value of clinical features, lung function tests, cardiac catheterisation, …
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Multi-scale computational modeling of coronary blood flow: application to fractional flow reserve.
… Results. It was found that the length of large vessel stenosis and presence of microvascular disease are primary regulators of FFR. Further, the CT data provided a basis to investigate relationships between coronary geometry (structure) and blood flow (function) attributes. Discussion. The …
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A comparative analysis of statistical and machine learning models with application in AI-powered stroke risk prediction
Rapid detection of large vessel occlusion (LVO) is critical due to its high mortality and narrow treatment window. Although machine learning (ML) and deep learning tools show promise for LVO prediction, their clinical use is hindered by inconsistent pre-hospital data, variable LVO rates, limited …
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Prolylcarboxypeptidase protects from vascular dysfunction and promotes vascular repair
… repair. The animals have decreased presence of vessels in sub-cutaneous injections of matrigel and decreased endothelial sprouting from excised aortic segments. Full thickness skin wounds from PRCPgt/gt heal slower than wildtype mice at the visual level and have decreased invasive blood vessel …
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Design Of A Polysaccharide Derived Tissue Engineered Vascular Graft
… challenging target to engineer a native blood vessel stems from the need to find substitutes for pediatric patients born with congenital defects. The tissue engineering graft functions to bring various cells of the vasculature in close proximity to one another to enable intercellular signaling …
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Hull construction with composite materials for ships over 100 m in length
… industry requires high performance marine vessels, which demand increased structural integrity and durability, coupled with significant weight reduction and minimization of cost. The design and fabrication of a "large vessel" by use of composite materials is within the current technology. …
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Outcomes of mechanical thrombectomy at a single-centre tertiary level public health care hospital in South Africa
… standard of care for acute ischemic stroke from large vessel occlusion following randomized controlled trials performed largely in high-income countries. Limited data exists on its effectiveness in the real-world setting, particularly in low- and middle-income countries. We aimed to evaluate the …
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Endovascular Thrombectomy Peri-Procedural Recall: A Mixed Methods Study
… (EVT) phase for individuals diagnosed with large vessel occlusion (LVO) stroke. Methods: A convergent mixed methods study was conducted to understand the lived experience of individuals receiving EVT intervention for LVO stroke. The relationship between patient recollection of the …
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ACUTE ISCHEMIC STROKE: CANCER-RELATED STROKE AND MULTIMODAL ANALYSIS OF THROMBI.
… of retrieved thrombi from AIS patients with large vessel occlusion. Methods We examined AIS–cancer interactions using the Acute-Stroke-Registry-and-Analysis-of-Lausanne (ASTRAL, 2003–2024) and international collaborations, focusing on outcomes, antithrombotic and anticancer strategies, and …
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Intracranial Vascular Findings in a Tri-Ethnic Population – MR Phenotypes and Physiological Parameters
… physiology as well as into the prevalence of large vessel cerebrovascular disease as part of a multi-ethnic population-based investigation, presenting new evidence for morphological and pathophysiological differences between women and men, and between different ethnic populations.
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In silico modelling to advance arterial spin labelling magnetic resonance imaging
… above a set threshold as these encompass large vessels feeding capillary beds outside the imaging plane. This method of minimising non-capillary blood signal has been tested in a previous in silico human modelling study; however, it has only been tested under a restricted set of …
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Hereditary risk factors for stroke in humans - Association studies with emphasis on familial and genotypic factors
… to IS risk (OR=1.12; 95% CI: 1.04-1.20) and large vessel disease risk (OR=1.36; 95% CI: 1.13-1.64). This genetic effect of chromosome 9p21 on IS was however already known. None of the other 24 SNPs or compiled risk scores were significant. Conclusions and discussion Significant transmission …
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The role of immunosenescence in autoimmune/autoinflammatory pathogenesis of Behçet's disease
… and complications such as blindness and large vessel inflammation. Immunosenescence, aging of immune system, is related to increased susceptibility to infectious diseases, vaccine failure, and chronic low grade systemic inflammation. The role of immunosenescence in BD is not well …
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Gender differences in risk of neuropathology, cognitive decline and dementia in the Cognitive Function and Ageing Study (CFAS)
… tangles and neuritic plaques, small and large vessel atherosclerosis and arteriolosclerosis, and atrophy. The correlation between pathologies, their patterns of co-occurrence and their effect on risk of dementia showed minimal differences between men and women. The higher prevalence of …
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Clinical and angiographic outcome following percutaneous coronary intervention
… required to have a lesion in a "small" and a "large" vessel, has provided us with the opportunity to compare both the rates and nature of the restenosis process in the same patients. In this way we abolished clinical and procedure related variables that confound the results when using …