Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Large Animal Models"”.
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The development of electrolysis for local destruction of solid tumours / by Guy John Maddern.
… electrolytically produced lesions in small and large animal models, and then its effect on tumour cells in a small animal model.
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Mechanistic Investigation of A Hemostatic Keratin Biomaterial
… in controlling hemorrhage in both small and large animal models; however little is known about the mechanism by which these proteins aid in blood clotting. Inspection of the amino acid sequence of known keratins shows the presence of several cellular binding motifs, suggesting a possible …
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Impacts of maternal dietary fat intake on fetal development in an ovine model
… in humans, highlighting the need for affordable large animal models of human pregnancy for evaluating these interventions. The primary aim of this dissertation was to establish the utility of the pregnant sheep for this purpose given its well-established similarities to human pregnancy in terms …
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Study of Infection, Immunity, Vaccine and Therapeutics Using Gnotobiotic Pig Models of Human Enteric Viruses
… microbiota, gnotobiotic (Gn) pigs are a unique animal model for studying infection and immunity, and evaluating vaccine and therapeutics for human enteric pathogens. Here, we demonstrate Gn pigs as effective large animal models for human enteric viruses, through evaluating human enterovirus 71 …
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The Green Lane Valve: a Novel Decellularised Heart Valve
… as alternative conduits. Unfortunately, early models have proceeded to clinical use with catastrophic outcomes. The clinical performance of contemporary decellularised heart valves remains unknown. A novel, decellularised scaffold that outperforms standard, glutaraldehyde-treated bioprosthetic …
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Investigations of Ultrasound-Guided Histotripsy Ablation for Soft Tissue Sarcomas, Osteosarcomas, and Brain Tumors
… in a millimeter-scale focal region, applying large stresses and strains to targeted tissues. The cavitation "bubble cloud" generated during histotripsy treatment can be visualized in real time on ultrasound imaging, assisting with treatment guidance and monitoring. Past studies have …
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Spinal cord pathology of ovine CLN5 and CLN6 neuronal ceroid lipofuscinoses (Batten disease) : A thesis submitted in partial fulfilment of the requirements for the Degree of Master of Agricultural Science at Lincoln University
… South Hampshire sheep breeds respectively. These large animal models recapitulate the clinicopathological features of the human disease and have been instrumental in understanding the human condition and in the development of gene therapies. Affected sheep have a well-characterised pathogenic …
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Development of bioabsorbable braided vascular scaffolds for the intracranial circulation
… efficacy were also studied in vivo with pilot animal experiments. The bioabsorbable flow-diverting stent that we developed demonstrated mechanical properties similar to existing intracranial stents. They further showed low potential for hemolysis and thrombus formation on the stent struts, as …
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Microstructural non-linear finite-element analysis of rat myocardium with hydrogel biomaterial inclusions
… infarction (MI). Studies conducted on small and large animal models have yielded positive results in improving cardiac function and reducing adverse ventricular remodelling post-MI. These therapies have also recently entered phase I and II human clinical trials, with limited positive results, but …
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Swine applied ethology methods for a model of mild traumatic brain injury
… are part of everyday life, for both humans and animals. Organisms evolved well-developed mechanisms to cope with most stressors, and to recover from stress responses. Nevertheless, severe acute stressors and chronic stressors lead to health problems. Traumatic brain injury (TBI) is defined as …
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The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease
… pathway expression in the descending airways of large animal models and to investigate the role of BMP signalling during adult airway homeostasis, recovery and disease. To investigate the role of BMP signalling in malignant lung disease we used a heterogeneous lung cancer cell line DLKP. We …
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Use of physical enhancers for gastrointestinal and transdermal drug delivery
… results in more permeable LTRs, in addition to larger LTRs. This phenomenon was not previously realized. Furthermore, the safety of this method is assessed through blinded histological evaluation of skin samples treated both in vitro and in vivo. This investigation demonstrated that …
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Towards an autologous tissue engineering construct for craniofacial bone repair
… to heal critical-size bone defects in a porcine animal model. During coagulation of whole blood, fibrin scaffolds were modified using treatments to reduce red blood cell density and porosity or increase concentrations of calcium and phosphate ions. Platelet-rich plasma was collected using an …