Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Lanthipeptides"”.
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Biosynthesis and engineering of lanthipeptides
… post-translational modified peptides (RiPPs). Lanthipeptides are a class of RiPPs with pharmaceutically valuable properties including antimicrobial activity against clinically-relevant bacterial pathogens, even including drug-resistant strains. These peptides are characterized by thioether …
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Exploration of the biosynthesis of lanthipeptides
… and post-translationally modified (RiPPs). Lanthipeptides, which possess (methyl)lanthionine structures, are a class of intensively studied RiPPs. Based on the biosynthesis enzymes that introduce the thioether motifs, lanthipeptides are classified into four classes. Class I lanthipeptides …
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Investigation of lanthipeptides and their applications
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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The biosynthesis and discovery of lanthipeptides
… structural diversity and potential applications. Lanthipeptides are one class of natural products that have provided antibiotics to the food industry and drug candidates for treating human diseases. Lanthipeptides are polypeptides enzymatically decorated with lanthionine rings and sometimes other …
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Ecology and evolution of lanthipeptides in marine picocyanobacteria
… and functionally complex molecules in nature. Lanthipeptides are ribosomally derived peptide secondary metabolites that undergo extensive post-translational modification. Most lanthipeptides are bactericidal but they are also known to act as signaling molecules or morphogenetic peptides, …
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New chemical and biosynthetic methodologies for the study of lanthipeptides
… of RiPPs is the lanthionine-containing peptides (lanthipeptides), which are characterized by intramolecular thioether crosslinks dubbed lanthionine (Lan) and methyllanthionine (MeLan). The evolvability and brevity of lanthipeptide biosynthetic pathways as well as the substrate tolerance of the …
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Mechanistic studies of lanthipeptide biosynthetic enzymes and discovery of novel lanthipeptides
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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Discovery and structural characterization of lanthipeptides from soil and rumen bacteria
… modified peptide natural products (RiPPs), lanthipeptides possess myriad structural diversity and potential for discovery using genome-guided approaches. Biological activities of interest embedded within lanthipeptide structures include antimicrobial, antiviral, and morphogenetic functions. …
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Mechanistic and synthetic studies on the prochlorosin and cytolysin families of lanthipeptides
… Research in the van der Donk lab focuses on lanthipeptides, a class of ribosomally synthesized and post-translationally modified peptides (RiPPs) that commonly feature antibacterial activity and contain the characteristic thioether residues lanthionine (Lan) and methyllanthionine (MeLan). …
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Structural investigation of lanthipeptides involved in substrate controlled pathways and methods for leader peptide removal
… natural products with diverse activities, with lanthipeptides as one of the most prominent classes. The diverse ring topology of lanthipeptides is formed by four classes of enzymes with substrate tolerance that holds potential for development of biotechnological techniques for macrocyclizations …
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The characterization of two novel class II lanthipeptides from Thalassomonas viridans by heterologous expression in Escherichia coli
It is estimated that in 2022, 4.95 million people died from illnesses where antimicrobial resistance played a role, of which 1.27 million people died as a direct result of antimicrobial resistance. With the rising emergence of antibiotic-resistant microorganisms, there is an urgent need for the …
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The characterization of two novel class II lanthipeptides from thalassomonas viridans by heterologous expression in escherichia coli
It is estimated that in 2022, 4.95 million people died from illnesses where antimicrobial resistance played a role, of which 1.27 million people died as a direct result of antimicrobial resistance. With the rising emergence of antibiotic-resistant microorganisms, there is an urgent need for the …
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Mechanistic studies of lanthipeptide biosynthesis
… symptoms, novel natural products are demanded. Lanthipeptides are ribosomal peptides with post-translationally incorporated thioether crosslinks named lanthionine. This family of natural products has garnered substantial attention during the past few decades due to their favorable biological …
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Development of lanthipeptide engineering strategies
… important source of therapeutic compounds. The lanthipeptides, members of the ribosomally synthesized and post-translationally modified peptide class of natural products, have potential applications ranging from clinical imaging to cystic fibrosis treatment. Additionally, many lanthipeptides …
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Chemical and chemoenzymatic syntheses of lantibiotics and other bioactive cyclic peptides
… One emerging family of natural products, the lanthipeptides, is defined by the presence of the thioether-containing crosslinks lanthionine and methyllanthionine and includes many members with promising activities against clinically-relevant bacterial pathogens, including drug-resistant …
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Investigation and application of substrate tolerant thioether forming enzymes
… thioether containing natural products. Lanthipeptides contain thioether rings and have demonstrated diverse biological activities. This group of natural products are of great interest due to their diverse ring topology and high substrate tolerance of the biosynthetic enzymes. Amongst …
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Investigations into the roles and molecular mechanisms of LanC-like proteins
Lanthipeptides are a family of ribosomally synthesized and posttranslationally modified natural products defined by the characteristic thioether crosslinks lanthionine and methyllanthionine. Among the various biological activities that lanthipeptides exhibit, the anti-microbial activities shown by …
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Investigating the Mechanisms of the Biosynthesis of Lexapeptide
… use. One class of useful antimicrobials are the Lanthipeptides. Lanthipeptides are characterised by the presence of lanthionine macrocycles and α,β-unsaturated amino acids such as 2,3-dehydroalanine (Dha) and (Z)-2,3-dehydrobutyrine (Dhb). Currently, the only lanthipeptide that has been approved …
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Diverse functions of LanC-like proteins in mammalian cells
… installing thioether crosslinks in precursors of lanthipeptides. These modifications allow lanthipeptides to possess different biological activities such as antimicrobial activity. LanC-like proteins have been identified in various eukaryotic cells, but their function is not known. Intriguingly, …
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Mechanistic studies of class II lanthipeptide synthetases and yeast surface display of lanthipeptide leader peptides
Lanthipeptides are natural products that belong to the family of ribosomally synthesized and posttranslationally modified peptides (RiPPs). They contain the characteristic lanthionine (Lan) or methyllanthionine (MeLan) structures that contribute to their diverse biological activities. ProcM is a …
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