Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Lanthionine synthetase"”.
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Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2
Lanthionine synthetase C-like protein 2 (LANCL2) is a member of the LANCL protein family, which is broadly expressed throughout the body. LANCL2 is the molecular target of abscisic acid (ABA), a compound with insulin-sensitizing and immune modulatory actions. LANCL2 is required for membrane binding …
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Mechanistic studies of lanthipeptide biosynthesis
… incorporated thioether crosslinks named lanthionine. This family of natural products has garnered substantial attention during the past few decades due to their favorable biological activities and the potential for engineering. This thesis focuses on a subclass of lanthipeptides, the …
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Structural investigation of lanthipeptides involved in substrate controlled pathways and methods for leader peptide removal
… the structural characterization and mechanism of lanthionine synthetases is fully understood. However, a difficult obstacle for high throughput studies of these natural products is removal of the leader peptide. Chapter 2 discusses the development of a general method using unnatural amino acid …
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Mechanistic studies of class II lanthipeptide synthetases and yeast surface display of lanthipeptide leader peptides
… (RiPPs). They contain the characteristic lanthionine (Lan) or methyllanthionine (MeLan) structures that contribute to their diverse biological activities. ProcM is a promiscuous bifunctional synthetase that catalyzes both dehydration and cyclization of the lanthipeptides. Its 30 substrate …
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Repurposing BT-11 to Treat Alzheimer’s Disease: Exploring the Glutathione-s-transferase LANCL2 as a Target
… such drugs is BT-11, which is an orally active lanthionine synthetase C-like 2 (LANCL2) binding compound, shown to reduce inflammation in the gut and improve cognitive function. Additionally, LANCL2 was identified as a glutathione-s-transferase, suggesting a role in removing toxins and reducing …
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Investigations into the roles and molecular mechanisms of LanC-like proteins
… by the characteristic thioether crosslinks lanthionine and methyllanthionine. Among the various biological activities that lanthipeptides exhibit, the anti-microbial activities shown by many members of the family (hence named lantibiotics) have drawn the most attention and make them …
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Exploring and understanding lantibiotic biosynthesis
… lanthipeptides are thioether crosslinks, called lanthionine and methyl lanthionine. The crosslinks are formed via the dehydration of serine and threonine residues to dehydroalanine (Dha) and dehydrobutyrine (Dhb) residues, respectively, followed by Michael-type addition of cysteines to the …