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Showing 1 to 9 of 9 for “"Langerhans cell"”.
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Σύγχρονα δεδομένα για τη διάγνωση και θεραπεία της ιστιοκύττωσης Langerhans / Current concepts for the diagnosis and management of Langerhans cell histiocytosis
Η ιστιοκύττωση Langerhans αποτελεί σπάνια ιστιοκυτταρική διαταραχή με ιδιαίτερα ετερογενή κλινική εικόνα, η οποία μπορεί να κυμαίνεται από εντοπισμένη, αυτοϊώμενη νόσο έως πολυσυστηματική μορφή με σοβαρή νοσηρότητα και αυξημένη θνητότητα. Η νόσος χαρακτηρίζεται από κλωνικό πολλαπλασιασμό …
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Outcomes of children with biopsy-proven Langerhans cell histiocytosis (LCH) treated at the Red Cross War Memorial Children's Hospital from 1998 – 2017
Background: Langerhans Cell Histiocytosis (LCH) is a rare histiocytic disorder characterised by the infiltration of a single organ or multiple organs by cells phenotypically similar to Langerhans cells. The number and type of systems involved affect the outcome and the longer the maintenance …
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The role of Id2 (inhibitor of differentiation, DNA binding) in dendritic cell development in steady state and inflammation
Dendritic cells are professional antigen presenting cells that capture antigens and migrate to lymphoid tissues where they elicit specific immune responses. Several DC subtypes have previously been characterised, depending on their function and location. Each subtype appears to have a specialised …
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Vip And Host Immunity
… anti-inflamamtory TLRs in macrophages and Langerhans (XS52) cells. Exogenous VIP also decreased Langerhans cell number in the infected cornea.</p> <p>Furthermore, we used VIP-/- mice to asses whether VIP is required for expression of growth factors and their receptors in normal and infected …
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Deficiência de arginina-vasopressina (diabetes insipidus central) como primeira manifestação de histiocitose de células de Langerhans: relato de caso
Introduction: Langerhans cell histiocytosis (LCH) is a rare clonal neoplasm of the mononuclear phagocyte system characterized by proliferation of CD1a⁺/Langerin⁺ myeloid dendritic cells and activating mutations in the MAPK/ERK pathway (such as BRAF V600E and MAP2K1). Involvement of the …
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Human immunodeficiency virus (HIV) and Human papillomavirus (HPV) infection and cell cycle regulators in preinvasive lesions and invasive carcinomas of the anus
… The majority of these carcinomas are squamous cell carcinomas and are associated with high risk-HPV infection. HIV infection appears to interact synergistically with high risk-HPV in the development of squamous cell carcinoma at this site. Aims and objectives: To review the pathology of anal …
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Immunogeneic Cell Populations of the Skin
Dendritic cells (DCs), a hematopoietic cell type belonging to the sub-group of cells called antigen presenting cells (APCs), inhabit a central role in innate and adaptive immunity. Although the DC family is very heterogeneous, all members share unique features. Most importantly, DCs can stimulate …
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New Roles of the Transcription Factor NKX6.1 in Beta Cell Biology
Pancreatic islet beta cells play a critical role in the maintenance of metabolic fuel homeostasis. Type 1 diabetes results from autoimmune destruction of the beta cells, whereas type 2 diabetes involves loss of beta cell function, particularly glucose-stimulated insulin secretion (GSIS), and a …
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Novel Roles of Gastrin and Cholecystokinin in Islet Beta Cell Proliferation
… share a common theme: an insufficient beta cell mass to maintain glucose homeostasis. In Type 1 diabetes this deficiency arises from autoimmune destruction of the beta cells. In the latter stages of Type 2 diabetes, there is a precipitous drop in beta cell mass, resulting from the …