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Showing 1 to 20 of 40 for “"Langendorff"”.
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Kardioprotektion durch Veränderung des Zytoskelettes im Langendorff-Hypoxie-Modell der Ratte
In this work changes of the cytoskeleton of cardiomyocytes are examined on the basis of isolated, perfused rat's hearts by the application of the different drugs which are also combined together. The effects of different drugs on the cytoskeleton, before all in the ischaemic phase, are examined on …
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Ex-Vivo Slaughterhouse Porcine Crystalloid-Perfused Beating Heart via Langendorff Method
… instead of blood via an extracorporeal Langendorff apparatus. The isolated beating heart functions outside of the body under simulated physiologic conditions. Live functional anatomy was controlled under benchtop experimental settings. Porcine hearts (26 total) were topically cooled with …
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Effects of Perfusate Composition (Na+ and Ca2+) on Cardiac Electrical and Mechanical Function in the Isolated Langendorff-Perfused Heart
… rule. In our systematic review of the ex vivo Langendorff-perfused heart, we found methods reporting to be sparse at best, specifically as it pertains to documenting the ex vivo perfusate compositions employed in the Langendorff heart. Our lab has demonstrated that variation in perfusate …
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Absolute Concentration Determination of Phosphorus Metabolites in the Langendorff-Perfused Rabbit Heart by Phosphorus-31 Nuclear Magnetic Resonance (Quantification, Metabolism, Intact Tissue, Nmr)
… phosphorus metabolites and intracellular pH of Langendorff-perfused rabbit heart have been determined under control and reduced flow conditions. Absolute concentration determination was accomplished by Lorentzian lineshape analysis after development of hexachlorocyclotriphosphazene as an …
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Unterschiedliche autonome Innervation in Pulmonalvene, linkem Vorhof und rechtem Vorhof : eine elektrophysiologische und pharmakologische Charakterisierung
… decreased effective refractory period. In 36 Langendorff-perfused rabbit hearts effective refractory period of pulmonray veins, right atrium and left atrium were determined.
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The protective role of tumour necrosis factor alpha in the heart
… TNFα was used as a PC-mimetic in the isolated Langendorff perfused rat heart (Langendorff) preparation. Infarct size was used as the end point. In parallel with cell culture studies, TNFα again conferred preconditioning induced cardioprotection with partial abrogation of these effects with the …
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Direkte kardiale Effekte positiv inotroper Pharmaka bei Sepsis-induzierter kardialer Dysfunktion am isoliert perfundierten Rattenherzen
… Kontrollgruppe (n=24) isoliert und im Langendorff-Apparat perfundiert. Dobutamin, Dopamin, Epinephrin und Levosimendan werden in Konzentrationen von 10-9 M bis 10-3 M in zufälliger Reihenfolge appliziert. Elektrophysiologische, mechanische sowie metabolische Parameter werden gemessen …
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Die kardiale Wirkung einer chronisch-anabolen Gabe des Hormons Testosteron auf das Remodeling nach Myokardinfarkt bei weiblichen Ratten : Hinweise auf geschlechtsspezifische Effekte
… sowie die Perfusion der Herzen nach Langendorff statt. Im Anschluss wurden molekularbiologische Bestimmungen des α/β-MHC-Quotienten, von IGF-I und des Kollagengehalts am Herzen vorgenommen. Der Hauptbefund dieser Studie war, dass die chronisch-anabole Gabe des Hormons Testosteron bei …
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Hämodynamische Charakterisierung eines murinen Sepsis-Modells
… as well as tests on isolated hearts in a Langendorff setup with and without application of pharmacological drugs followed. Our data show that the induction of sepsis by CLP result in the characteristic features of a sepsis like they were observed in septic patients. Furthermore, we …
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Glucoseaufnahme am infarzierten Rattenherzen
… die Herzen entnommen und nach der Methode nach Langendorff (11 mM Glucose) perfundiert. Nach 10 Minuten wurde das Substrat gewechselt; statt 11 mM Glucose waren nun 5 mM Deoxyglucose (DG) und 5 mM Pyruvat zugesetzt. 31P NMR Spektren wurden über 30 Minuten aufgezeichnet. DG wird im Myokard …
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The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner
… cardiovascular leakage protocol involving Langendorff-perfused mouse hearts, αCT1 was found to protect the endothelium from thrombin-induced breakdown in cell-cell contacts. Barrier protection was accompanied by significant remodeling of the F-actin cytoskeleton, characterized by a …
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Einfluss des HMG-CoA-Reduktase-Inhibitors Simvastatin auf Überleben und hämodynamische Parameter im murinen Sepsismodell
… we performed studies in an isolated heart Langendorff setup. Inducing sepsis via CLP resulted in 100% lethality in untreated animals. Median survival time was extended from 28 hours in untreated to 108 hours in simvastatin treated mice. Performing echocardiography we observed a hypodynamic …
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Investigating the coordination of cardiac conduction and repolarization in ventricular myocardium
… using ionic and osmotic challenges to the Langendorff-perfused heart. In the first series of experiments, we show that reducing EpC via treatment with mannitol or hyponatremia can unmask conduction deficits that are otherwise below the resolution of detection in Scn5a+/- mice. …
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The Effects of total and partial inhibition of the sodium and pottassium-activated Adenosine Triphosphatase on the isolated perfused rabbit heart
… phosphate (CP) were studied in the isolated Langendorff-perfused rabbit heart.Changes in these parameters- were investigated in relation to the development of ventricular fibrillation (VF) and contractile failure.Sodium pump inhibition was effected either by reducing the perfusate K …
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Atrial arrhythmogenesis in a murine model of mitochondrial insufficiency
… cellular action potentials (AP) in a whole-heart Langendorff-perfused system revealed that the Pgc-1β-/- genotype was associated with an atrial arrhythmic phenotype that progressed with age. Young and aged Pgc-1β-/- hearts showed evidence of slowed AP conduction at the cellular level, through …
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Mechanisms of ventricular arrhythmogenesis in the age dependent Pgc-1β -/- model of mitochondrial dysfunction.
… cell action potential characteristics in intact Langendorff perfused whole hearts were then used both in programmed electrical stimulation studies and at incrementally paced steady states to investigate the electrophysiological characteristics that give rise to arrhythmia. These experiments …
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Divergent Roles of PI3K and Akt in Rapamycin-induced Cardioprotection against Ischemia-Reperfusion Injury
… global ischemia and 30 minutes of reperfusion in Langendorff model. In a separate series of experiments mice were either injected with DMSO or rapamycin for 30 minutes, 1 hour, and 2 hours before harvesting the hearts for Western blot analysis of levels of total or phosphorylated Akt at Ser473. …
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NOVEL STRATEGIES TO IMPROVE METABOLIC PARAMETERS AND PRECONDITION DIABETIC HEARTS AGAINST ISCHEMIA/REPERFUSION INJURY
… Another set were subjected to IRI in a Langendorff model. Plasma samples were taken to measure plasma concentrations of cytokines. For miR expression, total RNA was isolated from TAD and DMSO treated mice and was subjected to reverse transcription and real time PCR using miR assay probes …
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