Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Landscape theory."”.
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Physical models of protein folding within the energy landscape theory
The energy landscape theory of protein fol9.ing is based on a statistical description of a protein's complex potential energy surface. Individual folding events are sampled from an ensemble of possible routes on the landscape. The theory suggests that the landscape of a protein can be described as …
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Application of the Statistical Energy Landscape Theory to Protein Structure Prediction
… to narrow this gap. Using ideas from the energy landscape theory first introduced by Bryngelson and Wolynes, and database analysis, we have designed statistical mechanical energy functions for protein structure prediction by threading and simulated annealing molecular dynamics methods. These …
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K-means landscapes: exploring clustering solution spaces using energy landscape theory
… We present the application of energy landscape theory to the K-means cost function to elucidate its topography, which we deduce from K-means landscapes described in terms minima and transition states. We analyse K-means landscapes for Fisher’s Iris dataset, the glass identification …
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Applications of Funneled Landscapes: Protein Folding and Molecular Recognition
Energy landscape theory provides a general framework in which models can be used to describe complex macromolecular processes. A free energy functional model is formulated to describe protein folding which includes a specific potential, a polymer chain entropy, and explicit physically motivated …
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The evolution of convergence, growth, and diet under an adaptive landscape framework
… microevolution. In microevolution, an adaptive landscape is used to visualize the relationship between phenotype and fitness, through a series of peaks and valleys. The adaptive landscape, as a concept suggests that there is some phenotypic optimum, or a combination of phenotypes, that result in …
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The Creation of the Ottoman Landscape in Southeastern Europe: Fourteenth to Nineteenth Centuries
… interpretation of Ottoman Europe. Focused around landscape theory, the work primarily examined human settlement patterns and land use. The confines of the study were limited to territories that were at one time centrally controlled by the Ottomans in Europe. An Ottoman Europe was reconstructed by …
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Landschaft 1.0
The author examines the role of landscape in the so-called "digital age", verifies the suitability of that which we collectively term landscape for the computer-generated worlds of the digital age, and follows the theory behind the path of landscape into the digital codes of computer technology. …
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Intercultural Colonization and the Landscape: The Historical Archaeology of San Emigdio, South Central California
… and sense of belonging as they play out in the landscape during the transition from the Spanish/Mexican period into the American period, on a south central Californian landscape of the San Emigdio Hills. Drawing upon a variety of source material, from other disciplines and from the historical …
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The sign models of Sassure and Pierce and the glossematic model of Hjelmslev: an analysis of the Vietnam Veteran's Memorial
Cultural meaning has been a critical dimension of landscape design over several thousands of years. Recent literature submits that the strength of cultural meaning has waned over the last century. It is also suggested, however, that the landscape architect is in a unique position to strengthen the …
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Studies of Protein-Protein and Protein-Water Interactions by Small Angle X-Ray Scattering, Terahertz Spectroscopy, ASMOS, And Computer Simulation
… biological physics due to its complexity. Energy landscape theory based on statistical mechanics provides a thermodynamic interpretation of the protein folding process. We have been working to answer fundamental questions about protein-protein and protein-water interactions, which are very …
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A Sonic Arts Approach to Sound Design Practice
… The research also illustrates that sonic landscape theory (Wishart 1986; 1996) constitutes a creatively enabling conceptual framework for sound design when it is applied to the inter-modal compositional strategy.<br/>
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Barrier Heights and Diffusion Coefficients in Protein Folding
… all-or-none transition. However, the energy landscape theory of protein folding predicts small and even zero folding free energy barriers (downhill folding) because of partial or complete compensation between large enthalpic and entropic terms as folding proceeds. They have been recently …
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On the role of conformational flexibility in viral fusion mechanisms - fusion by disorder
… distributions of the entire functional landscape through standard molecular dynamics calculations is not currently feasible. In this body of work, we employ structure based models to analyze the conformational dynamics of a range of viral fusion proteins. Structure based models have …
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Archipelagos of Interstitial Ground: A Filmic Investigation of the Thames Gateway’s Edgelands. How Can a Multimodal (Auto)ethnographic Methodology Be Deployed to Shape Geographic Imaginations of The Thames Gateway?
… towards the representation and production of landscape. As a result of this methodology, I document the shift within my practice from a topographic photography tradition to a filmic, ‘more-than-visual’ (Jacobs, 2013: 714) mode of production, in response to ideas of creative ethnography as an …
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Synesthetic Landscapes in Harold Pinter’s Theatre: A Symbolist Legacy
… interdisciplinary critical approaches to<em> landscape</em> and <em>space</em>, and adopting <em>phenomenological</em> methods of <em>sensory</em> analysis, this dissertation explores interconnected or <em>synesthetic</em> sensory "scapes" in contemporary British playwright Harold Pinter's …
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Evolutionary Fitness of Non-Coding Genetic Elements
… amino acid sequences. We also discuss the energy landscape theory and the physical energy function-- the Associative Memory, Water Mediated, Structure and Energy Model (AWSEM)--informed by the theory's principles. We finally discuss the Direct Coupling Analysis (DCA) model, which, when used …
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Anaerobic, NADH-Dependent Haem Breakdown in a Family of Haemoproteins
… experimental methods were combined with Energy Landscape Theory. Deuterium labelling demonstrated that the reaction was initiated by hydride transfer and stopped-flow spectroscopy showed that the reaction proceeded $\textit{via}$ a short-lived intermediate. Since no structural information …
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Self-assembly and aggregation of glucagon-like peptide 1 and its analogues
… slows down the fibrillation rate. Energy Landscape Theory was employed to investigate and rationalize the conformational behaviour and aggregation propensity of GLP-1 in different protonation states. Under all conditions studied, the GLP-1 energy landscape possesses a multi-funnel …
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Theory of carrier transport in III-Nitride based heterostructures
… the alloy microstructure: A 3-dimensional energy landscape is extracted which includes an atomistic description of alloy fluctuations, local strain, and local polarization. This can be used as a confining potential for electrons and holes, and quantum corrections can be included in a numerically …
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The middle of nowhere: the photographic search for an unknown landscape
… in helping us form a connection to an unknown landscape? Our modern world is explored, mapped, and imaged in its entirety. With the aid of satellites, global positioning systems, the Internet, closed circuit television, tourists with cameras, and mobile camera phones, there is no landscape left …
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