Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Lamins"”.
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Novel Roles for A-Type Lamins in Maintaining Genomic Stability
A-type lamins, key structural components of the nucleus, have been implicated in the maintenance of nuclear architecture and chromatin organization. Mutations in A-type lamins have been associated with defects in a number of nuclear processes, including DNA replication and repair, and gene …
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Novel Intermediate Filaments in the Nuclear Envelope: Molecular Cloning and Analysis of Lamins A and C
<p>Lamins A, B and C are the major polypeptides of the nuclear lamina, the filamentous meshwork intercalated between chromatin and the inner nuclear membrane. Amino acid sequences have been deduced from cDNA clones of human lamins A and C which show identity with the exception of an additional 98 …
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UNDERSTANDING LAMIN A/C AND ITS ROLES IN DISEASE PATHOLOGIES
THE NUCLEAR LAMINA, COMPRISED OF THE A AND B-TYPE LAMINS, REGULATES CHROMATIN ORGANIZATION AND GENE TRANSCRIPTION. MOUSE MODELS WERE DERIVED TO STUDY THE ROLE OF THE A-TYPE LAMINS IN INTESTINES AND SKIN HOMEOSTASIS AND ONCOGENESIS. MICE LACKING LMNA IN THEIR GASTROINTESTINAL (GI) EPITHELIUM HAVE NO …
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Lamin A and lamin C are differentially dysfunctional in autosomal dominant Emery-Dreifuss muscular dystrophy
… C proteins by alternative splicing. These A-type lamins, together with B-type lamins, form the nuclear lamina, a network of intermediate filament proteins underlining the nuclear envelope. In order to ascertain the role lamin A and C separately contribute to the molecular phenotype, we analysed …
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A putative interaction between mitochondrial cytochrome c oxidase subunit II (COX II) to lamin A/C and LAP2α in colon epithelial cells.
The lamina is a cage-like structure, composed of lamins, found underneath the inner nuclear membrane (INM). In mammals, Lamins are type V intermediate filaments. Three genes encode seven different lamin proteins. These genes are LMNA, LMNB1 and LMNB2. Lamins are classified into A- and B-types. …
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A New Pathway Responsible For 53BP1 Loss in Breast Cancer and Laminopathies
… genomic instability in cells that lack A-type lamins and work by others has shown that loss of 53BP1 is associated with breast cancers of the poorest prognosis - BRCA1-mutated and Triple Negative Breast Cancers: TNBC) - and contributes to their resistance to current therapies, such as PARP …
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Characterizing the Role of the Herpes Simplex Virus Type 2 UL21 Protein in Viral Nuclear Egress
… UL21 in disrupting the localization of nuclear lamins during infection. Nuclear rim localization of lamins A, C, B1, and B2 was indistinguishable between the wild-type (WT), UL21 null (∆UL21), or repaired (∆UL21R) HSV-2 strains, suggesting UL21 is not implicated in the disassembly of nuclear …
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Islet Dysfunction In Diabetes
… their target substrates; specifically nuclear lamins. </p> <p>Results obtained from our studies in pure beta cells [INS-1 832/13], primary rodent and human islets strongly suggest that glucotoxicity induced pancreatic beta cell damage involves the degradation of nuclear lamins A and B, via ER …
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Identificazione delle Lamine di tipo A come nuovi substrati della protein chinasi Akt/PKB
… antibody. This study presents evidence of A-type lamins as novel nuclear substrates of Akt. Lamins are type V intermediate filaments proteins found in the nucleus of higher eukaryotes where, together with lamin-binding proteins, they form the lamina at the nuclear envelope, providing mechanical …
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Mechanisms of epigenetic regulation in epidermal keratinocytes during skin development. Role of p63 transcription factor in the establishment of lineage-specific gene expression programs in keratinocytes via regulation of nuclear envelope-associated genes and Polycomb chromatin remodelling factors.
… accompanied by decreased expression of nuclear lamins (Lamin A/C and Lamin B1), proteins of the LINC complex (Sun-1, nesprin-2/3) and Plectin. Plectin links components of the nuclear envelope (nesprin-3) with cytoskeleton and ChIP-qPCR assay with adult epidermal keratinocytes showed p63 binding …
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Lessons from a rare disease
… in the LMNA gene, which makes proteins called lamins that comprise the inner lining of the nuclear wall. The mutation leads to the production of a misshapen lamin called progerin that builds up with time, disrupting nuclear shape and function. It is not yet clear how these changes lead to the …
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Diverse Roles Of Nuclear Intermediate Filaments In Proliferating Cells
… attrition, and cell cycle arrest. Nuclear lamins thus have different roles in responding to and regulating cell cycle.
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Impact of delta-tocotrienol on human melanoma cell proliferation
… proteins including nuclear Ras, nuclear lamins, and growth factor receptors. d-δ-tocotrienol, a post-transcriptional down-regulator of HMG CoA reductase, suppresses the proliferation of marine B16 melanoma cells and human blood, breast, cervix, colon, liver, lung, lymph gland, nerve, …
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Developmental Appearance of Phosphorylated Intermediate Filaments in Nuclei of Glioma and Neuroblastoma Cells
… (IF) in the nucleus have primarily focused upon lamins, however some studies have suggested that there may be a role for non-lamin intermediate filaments in the nucleoskeleton. Recent studies of glioma and neuroblastoma cell lines have suggested that phosphorylated derivatives of IFs normally …
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Mechanotransduction at the nuclear envelope: the role of forces in facilitating embryonic stem cell fate decisions
… proteins in the nuclear envelope, notably, the lamins (LMNA), Lamin B receptor (LBR) and components of the LINC complex (nesprins/KASH). The structural proteins in the nuclear envelope regulate both the mechanical response of the nucleus to force and the stabilization of peripheral …
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Prelamin A Influences a Program of Gene Expression In Regulation of Cell Cycle Control
<p>The A-type lamins are intermediate filament proteins that constitute a major part of the eukaryotic nuclear lamina—a tough, polymerized, mesh lining of the inner nuclear membrane, providing shape and structural integrity to the nucleus. Lamin A (LA) filaments also permeate the nucleoplasm, …
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Novel plant nuclear envelope-associated coiled-coil proteins
… of intermediate filament (IF) proteins called lamins, as well as lamin- and/or chromatin-binding inner nuclear membrane (INM) proteins. The components of the metazoan lamina lack sequence homologues in plants. There is however evidence of a network of nuclear filamentous proteins underlying the …
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Role of Zmpste24 in Prelamin A Maturation.
<p>The nuclear lamins form a karyoskeleton providing structural rigidity to the nucleus. One member of the lamin family, lamin A, is first synthesized as a 74 kDa precursor, prelamin A. Following the endopeptidase and methylation reactions which occur after farnesylation of the CAAX-box cysteine, …
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The genome of Euglena gracilis: Annotation, function and expression
… segregation, nuclear pore complex, nuclear lamins), protein trafficking, translation, surface, consist of conserved and divergent components. For instance, several gene families likely associated with the cell surface and signal transduction possess very large numbers of lineage-specific …
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Synthesis of Novel Isoprenoid Diphosphate Analogs as Chemical Tools to Investigate Protein Geranylgeranylation
… small Ras and Rho GTPase superfamilies, nuclear lamins A and B, and the kinesin motor proteins CENP-E and F. Prenyltransferase (PTase) inhibition is currently being explored as a possible treatment not only for cancer but for a wide variety of other diseases.</p> <p>Clinical studies revealed that …