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Showing 1 to 20 of 28 for “"Lamin A"”.
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Mechanism of Atrial Fibrillation in Lamin A/C Cardiomyopathy
Atrial fibrillation (AF) is a common arrhythmia with a complex genetic basis, yet the molecular mechanisms linking rare and common variants remain unclear. Polygenic risk score (PRS) assessment in the UK Biobank and All of Us cohorts shows that the risk of incident AF in carriers of …
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UNDERSTANDING LAMIN A/C AND ITS ROLES IN DISEASE PATHOLOGIES
THE NUCLEAR LAMINA, COMPRISED OF THE A AND B-TYPE LAMINS, REGULATES CHROMATIN ORGANIZATION AND GENE TRANSCRIPTION. MOUSE MODELS WERE DERIVED TO STUDY THE ROLE OF THE A-TYPE LAMINS IN INTESTINES AND SKIN HOMEOSTASIS AND ONCOGENESIS. MICE LACKING LMNA IN THEIR GASTROINTESTINAL (GI) EPITHELIUM HAVE NO …
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Lamin A and lamin C are differentially dysfunctional in autosomal dominant Emery-Dreifuss muscular dystrophy
… mutations in the LMNA gene which gives rise to lamin A and lamin C proteins by alternative splicing. These A-type lamins, together with B-type lamins, form the nuclear lamina, a network of intermediate filament proteins underlining the nuclear envelope. In order to ascertain the role lamin A and …
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A putative interaction between mitochondrial cytochrome c oxidase subunit II (COX II) to lamin A/C and LAP2α in colon epithelial cells.
The lamina is a cage-like structure, composed of lamins, found underneath the inner nuclear membrane (INM). In mammals, Lamins are type V intermediate filaments. Three genes encode seven different lamin proteins. These genes are LMNA, LMNB1 and LMNB2. Lamins are classified into A- and B-types. …
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Diverse Roles Of Nuclear Intermediate Filaments In Proliferating Cells
… role of two nuclear intermediate filaments - Lamin A and Lamin B1 in the proliferating cells of embryonic hearts and cancer. Lamin B1 is upregulated together with proliferation genes in at least 15 cancers curated in The Cancer Genome Atlas (TCGA), whereas Lamin A trends align with ‘matrix …
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Mechano-sensitivity of nuclear lamin proteins in endothelial cells
… and aging cells, implicating dysfunctions of lamin A/C in aging process and atherosclerosis, as HGPS is caused by a mutated form of lamin A/C. Blood flow in arteries is generating shear stress that is mostly applied on endothelial cells that align along inner blood vessel wall. At the same …
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The Application of a Statistical Model Investigating Reactive Oxygen Species in Premature Ageing Syndromes
… the post-translational processing of the protein lamin A. Lamin A is a Class V intermediate filament protein which resides in the cell nucleus, where it forms a cage-like structure against mechanical strain and is involved in transcriptional regulation, protecting the cell’s genome from damage. …
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Novel Intermediate Filaments in the Nuclear Envelope: Molecular Cloning and Analysis of Lamins A and C
<p>Lamins A, B and C are the major polypeptides of the nuclear lamina, the filamentous meshwork intercalated between chromatin and the inner nuclear membrane. Amino acid sequences have been deduced from cDNA clones of human lamins A and C which show identity with the exception of an additional 98 …
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Functional gene analysis in cultured vertebrate cells using siRNA mediated gene silencing
… prozessiert das Zellkernprotein prelamin A durch endoproteolytische Entfernung der carboxyterminalen 16 Aminosäuren zu reifem lamin A. Die Unterdrückung dieser proteolytischen Spaltung des prelamins A durch RNAi gegen FACE1 resultiert in der Akkumulation von nicht prozessiertem …
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Lamin C2
In der Kernlamina von Spermatozyten von Nagetieren sind die Lamin A-Genprodukte, Lamin A und C, durch eine meiosespezifische Splicingvariante ersetzt. Dieses Lamin C2 unterscheidet sich auffallend von den somatischen Varianten in Struktur, Menge und Verhalten. Durch eine ektopische Expression von …
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1, Structural and Functional Studies of Human Replication Protein A; 2 DNA Damage Responses and DNA Repair Defects in Laminopathy-Based Premature Aging.
… aging is caused by defective maturation of lamin A and linked to accumulation of DNA double-strand breaks (DSBs). However, how lamin A dysfunction leads to genome instability and premature aging is not understood. Here evidence showed that in HGPS and RD fibroblasts DNA damage checkpoints …
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Role of Zmpste24 in Prelamin A Maturation.
<p>The nuclear lamins form a karyoskeleton providing structural rigidity to the nucleus. One member of the lamin family, lamin A, is first synthesized as a 74 kDa precursor, prelamin A. Following the endopeptidase and methylation reactions which occur after farnesylation of the CAAX-box cysteine, …
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Structural and mechanical properties of intermediate filaments under extreme conditions and disease
… effect of calcium on the maturation process of lamin A. Our result shows that calcium plays a regulatory role in the post-translational processing of lamin A by tuning its molecular conformation and mechanics. Based on these findings we demonstrate that multiple-scale computational modeling …
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Identificazione delle Lamine di tipo A come nuovi substrati della protein chinasi Akt/PKB
… antibody. This study presents evidence of A-type lamins as novel nuclear substrates of Akt. Lamins are type V intermediate filaments proteins found in the nucleus of higher eukaryotes where, together with lamin-binding proteins, they form the lamina at the nuclear envelope, providing mechanical …
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A Study of Machine Learning Approaches for Integrated Biomedical Data Analysis
… related to Duechenne Muscular Dystrophy(DMD) and Lamin A/C(LMNA) using the integration of multi-omics data. We proposed a novel method which allows us to integrate proteins, mRNAs and miRNAs to find disease related pathways. The goal of the second project is to develop a personalized …
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Dynamic organization of chromosomes in the mammalian cell nucleus
… character looked at the influence of the nuclear lamina in constraining and determining a higher order nuclear architecture by selectively interacting with mid-to-late replicating chromatin. Simultaneous immunodetection of lamin B on two-color replication labeled neuroblastoma cell nuclei revealed …
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Prelamin A Influences a Program of Gene Expression In Regulation of Cell Cycle Control
<p>The A-type lamins are intermediate filament proteins that constitute a major part of the eukaryotic nuclear lamina—a tough, polymerized, mesh lining of the inner nuclear membrane, providing shape and structural integrity to the nucleus. Lamin A (LA) filaments also permeate the nucleoplasm, …
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Changes in the Oligodendrocyte Progenitor Cell Nuclear Lamina During Ageing
… was to explore a possible role of the nuclear lamina (a nucleoplasmic protein scaffold) in the functional response of OPCs to the mechanical properties of their microenvironment. Work in this thesis identified changes in the expression levels of the nuclear lamina proteins Lamin A/C and Lamin …
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Induction of Caspase-Dependent Death By Proteasome Targeted Therapy In Glioblastoma
… tumors. Examination of cleaved caspase 3 and lamin A as markers of apoptosis in brain tumors from mice showed increased cell death after treatment with BTZ or MRZ and the histone deacetylase inhibitor vorinostat. Together, this data clarifies the optimal strategy for proteasome targeting in …
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Differentiation Induces Dynamic Alterations in Mesenchymal Stem Cell Nuclear Architecture and Mechanotransduction
… of nuclear structural elements (i.e. lamin A/C and chromatin). These changes increased nuclear mechanical properties, resulting in changes tto he manner in which MSCs respond to external mechanical perturbation. In addition, through a series of micromechanical experiments, the …
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