Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Lactate transporter"”.
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Metabolic Targeting Of Malignant Glioma: Modulation Of Glycolytic Flux By Erythropoietic Factors
… from the cytosol by selective monocarboxylate transporters expressed on the plasma membrane. GATA response element islands are present on the promoter of glioma lactate transporter genes, and GATA-1 has been shown to be over-expressed in glioblastoma. Our long-term goal is to inhibit glioma …
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Computational modeling of tumor cell growth as a function of nutrient dynamics guided by time-resolved microscopy
… that predicts how the dynamics of glucose and lactate influence tumor metabolism and development. Firstly, we developed a baseline model that predicts tumor cell growth as a function of glucose availability. We employed time-resolved microscopy to track the temporal change in the number of live …
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Regulation of Akt ignal transduction by glucose metabolism
… of aerobic glycolysis in adipocytes through lactate production and hypothesised that this phenomenon is critical for adipocytes to enter the anabolic state. I therefore examined the effect of perturbing PFKFB3 activity on glucose metabolism and insulin signalling. The PFKFB3 inhibitor 3PO …
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Loss of basigin expression in the uterus reduces fertility in female mice
… migration, angiogenesis, tissue remodeling and lactate transport. Our data show that Bsg is expressed in the reproductive tract and is important for fertility in both males and females. I hypothesized that loss of Bsg expression in the uterus reduces fertility in female mice by altering …