Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"Lactamase"”.
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A genetic analysis of the secretion of β-lactamase
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1982.
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The effect of homoeopathic B-lactamase nosode on staphylococcus aureus
Dissertation submitted in partial compliance with the requirements for the Master's Degree in Technology of Homoeopathy, Technikon Natal, Durban, South Africa, 1998.
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Modellkomplexe für zinkhaltige Hydrolasen mit Schwerpunkt auf der ß-Lactamase
… Zwischenstufen im Katalyseprozess der ß-Lactamase untersucht. <br>Die Reaktionen von TpZnOH mit ß-Aminosäuren führten zu TpZn-ß-Aminosäurekomplexen, in welchen die Aminosäure nur über die Carboxylatfunktion an das Zinkion bindet. <br>Bei der Umsetzung von TpZnOH mit ß-Propiolactamen, …
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In vitro-Untersuchungen zum Sekretionsmechanismus der beta-Lactamase in Escherichia coli
… Ausnahmen. In dieser Arbeit wurde mit der beta-Lactamase ein sekretorisches Protein untersucht, das nicht auf SecB als exportspezifisches Chaperon angewiesen ist und somit keinem dieser Transportwege eindeutig zugewiesen werden kann. Zu Beginn dieser Arbeit war der Transportmechanismus der …
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Characterization of the metallo-ß-lactamase from Pseudomonas aeruginosa, IMP-1.
… in microbes are a class of enzymes known as β-lactamases. These enzymes are effective in breaking down the most commonly prescribed antibiotics at present. This work investigates two separate metallo-β-lactamase enzymes, first IMP-1, which provides antibiotic resistance to Pseudomonas …
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Transposon Tn5 mutagenesis in Pseudomonas aeruginosa: a study of Beta-lactamase expression
… the chromosomally-encoded, inducible class C B-lactamase gene of P. aeruginosa. Transposon mutagenesis was considered an effective method for the identification and subsequent cloning of such regulatory genes. To facilitate identification of Tn5 insertions in P. aeruginosa a transposon …
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Mechanisms of Regulation and Resistance for Plasmid-Encoded ampC Beta-Lactamase Genes
… of bacterial BETA-lactam resistance. BETA-lactamases are collectively the most commonly identified BETA-lactam resistance mechanism. The class C or, group 1 BETA- lactamases, can be chromosomal or plasmid-encoded. High-level expression of these genes results in resistance to almost all …
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EXTENDED-SPECTRUM Β-LACTAMASE-, AMPC- AND CARBAPENEMASE-PRODUCING BACTERIA IN DOGS AND CATS
La resistenza antimicrobica (AMR) rappresenta una delle minacce più critiche per la salute globale, che compromette l'efficacia degli antibiotici e minaccia la salute sia umana che animale. L'aumento di batteri multiresistenti (MDR) mina l'efficacia dei trattamenti per le infezioni negli esseri …
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Antimicrobial Resistance Mediated By Synthesis of Richmond and Sykes Type I Beta-Lactamase
… are relatively resistant to hydrolysis by beta-lactamases have been developed. These new compounds have expanded antibacterial activity but also have posed several challenging clinical problems including therapeutic failures and relapses of infections. Strains most often involved are …
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Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae: Epidemiology, Risk Factors, and Duration of Carriage
In human medicine, the most important family of bacteria is Enterobacteriaceae, which includes genera and species that cause well-defined diseases and also nosocomial infections. These bacteria can give rise to numerous infections such as septicaemia and urinary tract infections. It is important to …
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Discovery and optimization of inhibitors and probes that target New Delhi metallo-[beta]-lactamase
… of β-lactam hydrolyzing enzymes, known as β-lactamases, threatens their clinical efficacy. β-lactamases typically have a conserved serine in their active site that serves as a nucleophile in hydrolysis of the β-lactam substrate. Codrugs in the form of covalent inhibitors that target this …
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Metallo-β-lactamase-like enzymes from non-pathogenic organisms: an illustration of functional promiscuity
… of antibiotic-degrading enzymes, the metallo-β-lactamases (MBLs). MBLs are a family of Zn(II)-dependent enzymes that inactivate most of the commonly used β-lactam antibiotics. In Chapter 1 a detailed review of the properties of these enzymes is presented. Novel MBLs are continuously discovered …
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Combatting β-lactamase-mediated antimicrobial resistance: from novel assays for inhibitor discovery to new diagnostics
… is endangered due to the production of β-lactamase enzymes by pathogenic bacteria. Collectively, these enzymes can inactivate every clinically available β-lactam antibiotic via a hydrolytic mechanism. Thus, infections caused by β-lactamase-producing bacteria are associated with markedly …
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Studies on the mode of action and beta-lactamase inhibitory properties of novel oxapenem compounds
… oxapenem compounds were evaluated for their ß-lactamase inhibitory and antibacterial properties. Two (AM-112 and AM-113) displayed intrinsic antibacterial activity with MICs of between 2 to 16µg/ml and 0.5-2µg/ml against Escherichia coli and methicillin-sensitive and -resistant Staphylococcus …
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Genetic and molecular characterization of origins of replication from beta-lactamase-producing plasmids of Neisseria gonorrhoeae.
… existing amongst the gonococcal beta-lactamase-producing plasmids. The second major aspect of this work deals with investigations into the genetic and molecular characterization of the multiple origins of replication of the gonococcal beta-lactamase-producing plasmids. The …
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Traitement des infections à entérobactéries productrices de béta-lactamase à spectre élargi: quelles alternatives aux carbapénèmes?
… : Les entérobactéries productrices de β-lactamases à spectre élargi (BLSE) sont responsables d’un nombre important d’infections liées aux soins, mais aussi communautaires. Des alternatives thérapeutiques aux carbapénèmes devraient être utilisées, notamment à cause de l’émergence des …
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Mechanisms Involved in the Expression of the AmpC Beta-lactamase Gene blaCMY-2 in Escherichia coli
… that express plasmid-encoded AmpC β-lactamases can be resistant to third generation cephalosporins and β-lactam/β-lactamase inhibitor combinations. Infections by these bacteria are associated with increased patient morbidity and mortality. Little is known about how plasmid-encoded …
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Molecular methods for the detection of TEM- and SHV-related beta lactamase genes in members of the Enterobacteriaceae
… bacilli is mediated predominantly by beta lactamases, enzymes able to hydrolyse the beta lactam ring. The commonest plasmid mediated beta lactamases in the Enterobacteriaceae are those related to either TEM-1 or SHY-1. Although TEM-1, TEM-2 and SHY-1 do not have activity against extended …
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