Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 184 for “"Lactam"”.
-
Preparation and some reactions of an α-lactam
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1964
-
AB initio studies of a pentacyclo-undecane cage lactam
Submitted in fulfilment of the requirements for the Degree of Master of Technology: Chemistry, Durban Institute of Technology, Durban, South Africa, 2003.
-
Mechanisms of resistance to β-lactam antibiotics in Streptomycetes
… of penicillin G is not directly related to β-lactamase production in the panel of isolates examined. There was no correlation between the MICs of penicillin G and the growth rate in these isolates. Likewise, there was no association between the position of beta-lactamase producing and …
-
Exploring and enhancing context-dependent beta-lactam antibiotic efficacy
Antibiotics, such as beta-lactams, are essential medical tools for the treatment of bacterial infections. Unfortunately, clinical treatment efficacy is declining over time as bacteria adapt to and evade antibiotic treatment through mechanisms called antibiotic resistance, tolerance, and …
-
Stereospecific total synthesis of beta-lactam antibiotics from peptide precursors.
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1978
-
Isolation and characterization of genes from beta-lactam antibiotic producing organisms
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Structural characterization of superbug proteins involved in regulating beta-lactam resistance
The widespread use of β-lactams has undermined their effectiveness as chemotherapeutic agents by fueling the evolution and dissemination of multiple resistance mechanisms, including: (1) production of hydrolytic β-lactamase enzymes that inactivate β-lactams, (2) expression of PBPs with …
-
Multivariate Methods for the Study of Beta-lactam Resistance in Streptococci
… of isolates. By applying these tools to beta-lactam resistance in streptococci, I demonstrate these methods can improve visualisation and modelling of complex phenotypes, assist in identifying the molecular basis of multivariate change, and aid in studying repeatable patterns in the evolution …
-
THE ROLE OF BACTERIA AND ß-LACTAM ANTIBIOTICS IN CANDIDA ALBICANS INFECTION
… albicans hyphal growth. Here, we report that β-lactam antibiotics cause bacteria to release large quantities of hyphal-inducing PGN subunits into the environment, including culture media and the GI tract of mice. Of high importance, massive hyphal growth in the GI tract of treated mice due to …
-
Synthesis of multicyclic ring systems including an alternate route to Meyers’ lactam derivatives
… construction of chiral fused oxazolidinone lactams by utilising the use of Meyers’ lactamisation methodology. This provided high atroposelection through a central C5 to axial chirality transfer. The aim of this project will be directed towards the design of alternative strategies in the …
-
The determination and characterisation of beta lactam resistance in clinical isolates of Acinetobacter baumannII
Bibliography leaves 122-136.
-
Selective Synthesis of Trans-fused Lactam-Lactones by Vicinal Difunctionalization of Readily Affordable Allylic Lactams
… plethora of medicinal properties. Specifically, lactams and lactones are the respective luminaries of the antibiotic and flavor worlds. However, the synthesis of fused lactams-lactones, especially those bearing <em>trans</em>-fusion, is challenging from the standpoints of chemoselectivity, …
-
Addressing the ongoing threat of antimicrobial resistance: synthetic investigations of novel amicetin and B-lactam antibiotics
… synthetic investigations of amicetin and novel -lactam therapeutics. Chapter 1 essentially highlights the role and importance of synthesizing complex chiral scaffolds and heterocycles in discovering new antibiotics by providing a brief historical context and background of disease etiology and …
-
Beta-lactam antimicrobial dosing optimization in obese patients compared to non-obese patients using population pharmacokinetic/pharmacodynamic approach
… pharmacodynamics of many broad-spectrum, beta-lactam antibiotics such as piperacillin/tazobactam, meropenem, and cefepime. The objective of this study is to evaluate the population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam, meropenem, and cefepime in hospitalized obese …
Page 1 of 10