Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"Lachnospiraceae"”.
-
The role of gut microbiota in systemic lupus erythematosus
… decrease of Lactobacillales but increase of Lachnospiraceae in the gut microbiota. Increasing Lactobacillales in the gut by suppling a mixture of 5 Lactobacillus strains improved renal function of these mice and prolonged their survival. Further studies revealed that MRL/lpr mice possessed a …
-
Role of the Gut Microbiome in Cancer Immunotherapy Efficacy and Side Effects
… with gut toxicity (Dubosiella and genera from Lachnospiraceae) or protection (UBA7173 and Paramuribaculum). Genera from Lachnospiraceae and Oscillospiraceae were linked to reduced ICI efficacy, as evidenced by larger tumours. Using polymyxin B to eliminate LPS-producing Gram-negative bacteria …
-
An Investigation of the Interplay Among CX3CR1, Immune Cells, and Gut Microbiota in Lupus-Associated Arthritis and Renal Disease using the MRL/lpr Mouse
… for lupus-associated kidney disease, the Lachnospiraceae-to-Oscillospiraceae ratio, was discovered, which may become a new method to help prescreen patients before a kidney biopsy has to be performed. Overall, these findings contribute to scientific knowledge and could lead to targeted …
-
Das Mikrobiom von stationären multimorbiden geriatrischen Patient:innen mit und ohne Idiopathischem Parkinson-Syndrom
… der kurzkettigen Fettsäuren (SCFA) bildenden Lachnospiraceae bei IPS-Patient:innen als Gruppenunterscheidungsmerkmal. Insgesamt weisen die Ergebnisse darauf hin, dass sich Unterschiede in der Mikrobiomzusammensetzung bei IPS-Patient:innen dieser spezifischen Kohorte weniger durch globale …
-
ANALYSIS OF MICROBIOME IN VARIOUS HUMAN MEDICAL CONDITIONS USING NEXT-GENERATION SEQUENCING OF THE 16S rRNA GENE
… the stool samples were <em>Anaerobutyricum, Lachnospiraceae, and Eubacteriales.</em> These specific microbiome signatures offer nuanced insights into ocular and gut health. This integrated approach enhances our capacity to understand gut-eye association and develop targeted therapeutic …
-
DELINEATING GUT-MEDIATED RESPONSE AMONG MELANOMA PATIENTS UNDERGOING ANTI-PD1 IMMUNOTHERAPY
… level, our data demonstrate a key role for Lachnospiraceae-carried flagellin genes in driving a productive anti-tumor response. Overall, we propose microbiota stability during ICI therapy as a consequential feature of an immune-beneficial Clostridia-rich gut, resulting in good response to …
-
Fermentable Carbohydrate Substrates Generated from Cereal and Pseudocereal Insoluble Dietary Fibers and Their In Vitro Fecal Fermentation
… TFS caused a significant increase in Lachnospiraceae and a decrease in Bacteroidaceae. Substrates from quinoa significantly promoted the Ruminococcaceae family and substrates from pearl millet were more bifidogenic. These results lay the groundwork for the design of fermentable …
-
Longitudinal effects of early-life iron status in pigs
… the Clostridium family including Clostridiaceae, Lachnospiraceae, and Ruminococcaceae. These findings suggest that early-life iron status causes profound shifts in growth performance and hematological outcomes, with only partial recovery following dietary iron repletion. Interestingly, VFA …
-
La microbiota intestinal como marcador diagnóstico en la esclerosis múltiple.
… Ezakiella, Family XIII (genero unnasigned), Lachnospiraceae FCS020 group, Roseburia, Anaerotruncus, DTU089, Oscillibacter, Ruminococcaceae UCG-013, gut metagenome, CAG-56, CHKCI002 y Bilophila, cuando se compararon con las muestras de los controles. Estos géneros fueron posteriormente …
-
Estudio descriptivo de la microbiota intestinal en pacientes con infección por Clostridium difficile y en individuos colonizados por Clostridium difficile.
… de familias productoras de butirato como Lachnospiraceae y Ruminococcaceae y el incremento de patógenos oportunistas, principalmente del phylum Firmicutes. Por otra parte, la tasa de portadores o colonizados por C. difficile es variable y dependiente de la edad. Es más elevada en aquellos …
-
The gut microbiome: a contributing mechanism to the anti-seizure effect of topiramate
… increased the butyrate producing family Lachnospiraceae and subsequently increased the neuroprotective SCFA, butyrate in the gut microbiome. Importantly, cotreatment also resulted in an increased GABA/glutamate ratio in the cortex of mice that underwent pentylenetetrazol-kindling. These …
-
Effects of iso-alpha-acids on rumen fermentation and comparison of microbial populations between rumens and continuous culture fermenters
… by sample type included Succinivibrionaceae, Lachnospiraceae and Paraprevotellaceae. PICRUSt predictions showed that amino acid metabolism, membrane transport, energy metabolism and cellular processes and signaling were different (P < 0.05) between sample types. Metabolism of carbohydrates, …
-
Causes and consequences of microbiome formation in Culex mosquitoes
… Enterobacteriaceae, Flavobacteriaceae, Lachnospiraceae, Porphyromonadaceae, Pseudomonadaceae, and Rhodocyclaceae) accounted for over 90% of the relative abundance in the larval samples. When rearing larvae to adulthood (Chapter 2), isolated larvae reared with higher resource …
-
Structural investigation of lanthipeptides involved in substrate controlled pathways and methods for leader peptide removal
… protease domain of a LanT-type transporter from Lachnospiraceae C6A11 with a substrate mimic offers molecular understanding of the recognition by this type of proteases. In addition, the chapter explores the substrate scope of this protease. The range of substrates tested constitutes only a …
-
Managing Poultry Gut Integrity, Immunity and Microbial Balance During Necrotic Enteritis
… Clostridium sensu stricto 1, Faecalibaculum, Lachnospiraceae UCG-001, Muribaculum, Oscillibacter, Parabacteroides, Rikenellaceae RC9 gut group, Ruminococcaceae UCG-014, and Ruminiclostridium 9 and increased the relative abundance of Lactobacillus compared to NE challenged birds. Collectively, …
-
Understanding the role of human microbiota on sensory perception
… genera mainly allocated to the families Lachnospiraceae and Ruminococcaceae was found to be enriched in individuals exhibiting lower acuity to both tastes (bitter, salty, sour, sweet) and trigeminal sensations (astringent, pungent). Besides taxonomically annotating a range of microbial …
-
Microbes for life; investigating the effects of oral administration of Lactobacillus mucosae DPC 6426 on cardiometabolic parameters
… in short-chain fatty acid-producing bacteria Lachnospiraceae, Rikenellaceae and Akkermansia in the porcine gut. In Chapter 5, using the previously established porcine model of MetS, the efficacy of daily oral supplementation of Lb. mucosae DPC 6426 and fibre, singly, or in combination, on the …
-
Metabolite biosynthetic enzymes: catalysis, substrate specificity and protein engineering
… lanthipeptide biosynthetic gene cluster from Lachnospiraceae bacterium C6A11, the final product of which is not yet known. This cluster contains diverse modifying enzymes that have not been seen to be encoded together in any previously characterized cluster. One of these enzymes is LahD1, a …