Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Label-free imaging"”.
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Label free imaging of cell attachment by photonic crystal enhanced microscopy
… and limitations of a newly developed imaging technique which is based on the special optical properties of a photonic crystal for imaging live cells. The imaging instrument utilizes a monochromatic angle-tunable illumination to achieve resonant conditions within the crystal sensor in …
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Developing Label-free Imaging Techniques to Study Biological and Energy Conversion Processes
… technologies, plasmonic-based electrochemical imaging (PECI). It images local reactions (both faradaic and non-faradaic) without using a scanning microelectrode. Utilizing the reflectivity from surface plasmon resonance (SPR), PECI is fast and non-invasive, and its signal is proportional to …
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Sensitive microarray-based biomarker detection using photonic crystal enhanced fluorescence and label-free imaging
… detection sensitivity and as a platform for label free (LF) detection utilized for microspot quality analysis and anticipated to complement the fluorescence modality. First, a demonstration of the PC enabled LF imaging is applied to the quality analysis of printed spots in a DNA microarray. …
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Photonic Crystal Enhanced-Fluorescence and Label -Free Bioimaging
… is outlined for predicting photonic crystal label-free imaging resolution based on resonance spectral characteristics. Devices are characterized by patterning a resolution standard onto the sensor using photolithography, and excellent design control over label-free imaging resolution is …
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Label-Free Functional Imaging Of Platelets At Nanoscale
… last few decades, the development of advanced imaging tools (optical, electrons, conductance, and atomic force) have revealed a highly heterogeneous distribution of platelet morphologies at the microscopic scale that spreads across a thrombus. Under platelet spreading assays, the membrane …
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Label-Free Functional Imaging Of Platelets At Nanoscale
… last few decades, the development of advanced imaging tools (optical, electrons, conductance, and atomic force) have revealed a highly heterogeneous distribution of platelet morphologies at the microscopic scale that spreads across a thrombus. Under platelet spreading assays, the membrane …
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Second Harmonic Generation – A Novel Approach in Retinal Imaging
… of Second Harmonic Generation (SHG) for label-free imaging of microtubules (MTs) in the retinal nerve fiber layer (RNFL). MTs are an important part of axonal cytoskeleton, providing structural support and serving as a railroad in intracellular transport. We demonstrate the application of …
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Imaging of Caenorhabditis Elegans with Near Infrared Spectrally Encoded Confocal Microscopy
… encoded confocal microscopy (SECM), for label-free imaging of C. elegans. The developed system utilizes near-infrared illumination in conjunction with refractive and diffractive optics to instantaneously image a confocal image line at a speed of up to 147 kHz with lateral and axial …
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Third Harmonic Generation: A Method for Visualizing Myelin in the Murine Cerebral Cortex
… use of Third Harmonic Generation (THG) for the label-free imaging of myelinated axons in the murine cerebral cortex. Myelin plays an important role in the processes of learning and disease. However, much of the myelin biology research thus far has focused on white matter tracts where myelin is …
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Multi-parametric photoacoustic/ultrasound localization (PAUL) imaging and its applications
Noninvasive biomedical imaging technologies play a critical role in medical diagnostics, yet each modality has inherent limitations in spatial resolution, functional sensitivity, or molecular specificity. Hybrid imaging approaches have been developed to address these limitations, providing …
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Deep and Dynamic Metabolic and Structural Imaging in Living Tissues
Label-free imaging through two-photon autofluorescence (2PAF) of NAD(P)H allows for non-destructive and high-resolution visualization of cellular activities in living systems. However, its application to thick tissues and organoids has been restricted by its limited penetration depth within 300µm, …
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Femtosecond CARS Microscopy to characterize lipid droplets in Engineered Adipose Tissue
… However, fluorescence staining limits multiplex imaging, and requires time consuming steps in preparing the samples for imaging. Therefore, developing a label-free, high resolution imaging platform with sensitivity to lipid composition could enable analysis of structural and compositional …
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Assessment and Diagnosis of Human Colorectal and Ovarian Cancer using Optical Imaging and Computer-aided Diagnosis
… and tumor angiogenesis. Spatial frequency domain imaging (SFDI), a powerful wide field, label-free imaging modality, is sensitive to both absorption and scattering. We designed a computer-aided diagnostic algorithm, AdaBoost, to use multispectral SFDI imaging for ex vivo assessment of different …
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Nonlinear optical microscopy and spectroscopy by pulse shaping of a coherent fiber supercontinuum
… enable three-dimensional sub-µm-resolution imaging with deeper penetration and reduced photodamage, and have been established as powerful methods in biomedicine. The most appealing aspect of nonlinear optical imaging is the wealth of molecular contrast derived from various multiphoton …
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Computational high-throughput phase imaging
Quantitative phase imaging (QPI) is a remarkable modality for its wide range of potentials in studying biological structures without exogenous labeling. QPI utilizes the optical phase delay across the sample, instead of the image intensity, as the image contrast mechanism to provide highly …
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Colocalization analysis for multimodal optical microscopy
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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Cellular and molecular mechanisms of liver regeneration
… means that the opportunity now exists to observe labelled cells, and subcellular structures, in real time and in vivo, with previously unobtainable resolution and fidelity. Not only does this afford the opportunity for novel insights into both normal physiology and the response to injury or …
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Advances in Raman hyperspectral compressive detection instrumentation for fast label free classification, quantitation and imaging
… lab and have proven to be useful for fast, label-free chemical identification, quantitation and imaging. The CD spectrometer consists of a volume holographic grating (VHG) that linearly disperses the Raman photons into its component wavelengths and all wavelengths are focused onto a digital …
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Label-free Optical Approaches for the Non-invasive Assessment of Embryo Quality
… fail to improve life birth rate. Optical imaging may address this gap providing an accurate and non-invasive means of assessing embryo quality. In recent years, optical imaging has gained prominence due to its innate capacity to unravel the intricacies of biological processes with …
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Label-free optical signatures of extracellular vesicles and their applications in disease diagnosis and therapy response
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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