Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"LXRs"”.
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Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels
… binding proteins (SREBPs) and liver X receptors (LXRs). This thesis describes the identification by microarray technology of novel genes in cholesterol metabolism and the characterization of two of these genes. Microarray analysis of the livers of mice fed a low versus high cholesterol diet …
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Biological and Chemical Investigation of Panamanian Plants for Potential Utility against Metabolic Syndrome
… receptors (PPARs), liver X receptors (LXRs), nuclear factor-κB (NF-κB), and inducible nitric oxide synthase (iNOS) which are key regulators of various processes leading to metabolic disorder and inflammation. As a part of inflammatory pathway, activation of NF-κB leads to insulin …
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Characterization of the Functional Role of the Intracellular Cholesterol Transporter StARD4 in Knockout Mice, and Investigation of Epigenetic Modulation of ApoA-I Transcription
… Binding Proteins (SREBPs), Liver X Receptors (LXRs) and Unfolded Protein Response (UPR) or ER stress families of transcription factors. StARD4 is regulated by SREBPs and we have chosen to make a mouse knockout model to characterize its role in-vivo. StARD4, expressed primarily in liver and …
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Genetic association study of interleukin 6 receptor and liver X receptor in systemic lupus erythematosus
… The recent studies have reported that LXRs are involved in regulation of inflammation and immune responses. Objective: We attempted to identify single nucleotide polymorphisms (SNPs) of the IL6RA, IL6RB, NR1H3 and NR1H2 genes, associated with the susceptibility to SLE in Korean …