Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"LXR"”.
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The Roles of ATP-Binding Cassette Transporters G5 and G8 in Liver X Receptor-Mediated Sterol Trafficking
The liver X receptor (LXR) is a nuclear receptor that plays a critical role in orchestrating the trafficking of sterols between tissues. Treatment of wild type mice with a potent and specific nonsteroidal LXR agonist, T0901317, is associated with increased biliary cholesterol secretion, decreased …
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Characterization of Novel Liver X Receptor Inverse Agonist in Breast Cancers
… dependence of cancer. The liver X receptors (LXR) are ligand-modulated nuclear receptors. LXR activation upregulates the expression of genes involved in altered metabolic pathways in cancer, including cholesterol transport, glucose, and lipid metabolism. Moreover, LXR inhibition using the …
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Anti-Inflammatory Mechanism By Oxysterols In Cultured Rat Brain Astrocytes
… cassette transporter a1 transcription, LXR-induced target gene, was increased by addition of either oxysterol or LXR agonist. Thus, I conclude that these effects are mediated by LXR/RXR heterodimers. Next, these inhibitory effects of oxysterols also appeared and were potentiated by RXR …
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Identification of molecular targets regulating fatty acid synthesis in bovine mammary epithelial cells
… binding protein-1 (SREBP1) and liver X receptor (LXR). In vivo, diet-induced milk fat depression or supplementing diets with polyunsaturated fatty acids inhibits milk fat synthesis by regulating SREBP1 expression. Results confirm that polyunsaturated fatty acids inhibit fatty acid synthesis in …
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Evaluating the Mechanisms of 2-Hydroxypropyl-β-Cyclodextrin and Liver X Receptor Agonists as Potential Therapies for Niemann-Pick Type C Disease
… in patients; however, two separate compounds (an LXR agonist and a cyclodextrin) have been shown to increase lifespan in the Npc1-/- mouse model. Although both of these potential therapies are known to alter cholesterol dynamics in the cell, the molecular mechanism(s) through which they are able …
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Studies on cholesterol metabolism in prostate cancer cells
… cholesterol levels, and (2) liver X receptor (LXR), which reduces cholesterol levels. From this, we found that cholesterol accumulation was stimulated by signals that promote PCa cell-growth for example, male sex hormones act via the androgen receptor (AR) to enhance SREBP-2 activity and …
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Regulatory factors of milk fat synthesis in dairy cows
… receptor γ (PPARγ), or liver X receptor (LXR). The activation of PPARγ and SREBP-1 were stimulated by insulin and insulin combined with leptin, respectively. Trans-10, cis-12 conjugated linoleic acid (CLA) inhibited SREBP-1 activation, and this inhibition was not attenuated by insulin and …
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Identification of a MicroRNA Network that Regulates Melanoma Metastasis and Angiogenesis by Targeting ApoE
… identified the nuclear hormone liver-X receptor (LXRβ), a known transcriptional trans-activator of ApoE, as an ideal target given its ubiquitous expression across all normal tissues as well as melanoma subtypes. Oral delivery of LXR agonists strongly suppressed melanoma tumor progression and …
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Prenatal Programming of Hepatic Glucose and Cholesterol Regulation in Male Rat Offspring by Chronic Intermittent Hypoxia
… gluconeogenic pathways by the Liver X Receptor (LXR), leading to increased expression of hepatic markers associated with gluconeogenesis and increased glucocorticoid signalling. Adult male CIH offspring were also hypercholesterolemic with decreased expression of LXR target genes associated with …
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Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels
… binding proteins (SREBPs) and liver X receptors (LXRs). This thesis describes the identification by microarray technology of novel genes in cholesterol metabolism and the characterization of two of these genes. Microarray analysis of the livers of mice fed a low versus high cholesterol diet …
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An interdisciplinary approach leveraging human genetic variation to identify novel mechanisms of liver disease and pregnancy sickness
… variants in the cholesterol sensing receptor LXRand undertook a functionally enriched human genetic association study. Using this approach, I demonstrated that loss of function mutations in LXR(Liver-X-Receptor-alpha) are a cause of hepatotoxicity in humans despite evidence of suppression …
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A Novel Subfamily of Three StAR-Related Lipid Transfer Proteins That Are Differentially-Regulated and Function in Intracellular Cholesterol Metabolism
… the testis. StarD5 was not activated by SREBP or LXR transcription factors, well-characterized regulators of cholesterol metabolism, but rather by the ER stress response, a recently-described means by which cholesterol regulates gene expression. The nematode C. elegans has one StarD4 subfamily …
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Gangliosides와 oxidized low density lipoprotein (oxLDL) 에 의한 신경교세포의 활성조절 및 그 기전에 대한 연구
… signaling pathways 8 3. Liver X receptor (LXR) pathway as anti-inflammatory signaling Pathway 9 D. Aims of study 10 II. MATERIALS AND METHODS 11 A. Reagents 11 B. Cell culture 12 C. Electrophoresis mobility shift assay (EMSA) 12 D. Reverse transcriptase-polymerase chain reaction (RT-PCR 13 …
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An In Vivo Characterization of the Functional Role of Two Novel Genes: StARD5 and ADAM11
… Binding Proteins (SREBP), the Liver X Receptors (LXR), and the Unfolded Protein Response (UPR)/ER Stress Response. This thesis attempts to characterize the in vivo physiological role of novel downstream target genes of these transcription factors: StARD5 and ADAM11. This thesis outlines the …
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Transcriptional Regulation of Matrix MetalloProteinase-3 in Rat Brain Astrocytes.
… in EMSA analysis. Further, we demonstrated that LXR activation inhibit MMP-3 transcription through interaction with AP-1.
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Lung Defects Contribute to Respiratory Symptoms in a Mecp2-mutant Mouse Model of Rett Syndrome
… including statins and liver X receptor (LXR) agonists; both improved neurological and respiratory symptoms, suggesting clinical utility. Altogether, these findings implicate key functions of Mecp2 in the lung and highlight the importance of studying non-neuronal aspects of RTT. Our …
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Chlamydia pneumoniae, Toll-like Receptors and Pathogenesis of Atherosclerotic Heart Disease
… cell formation. A synthetic liver X receptor (LXR) agonist (GW3965) enhances cholesterol efflux and reduces foam cell formation by TLR2, TLR4 and TLR7, but not TLR3.</p> <p>Collectively, these results indicate that TLR-mediated foam cell formation occurs via two pathways: one is mediated by …
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Biological and Chemical Investigation of Panamanian Plants for Potential Utility against Metabolic Syndrome
… receptors (PPARs), liver X receptors (LXRs), nuclear factor-κB (NF-κB), and inducible nitric oxide synthase (iNOS) which are key regulators of various processes leading to metabolic disorder and inflammation. As a part of inflammatory pathway, activation of NF-κB leads to insulin …
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Modeling and Validation of Gene Networks in Breast and Pancreatic Cancer
… the cytotoxic effects of liver x receptor (LXR) β activation in pancreatic cancers. This study revealed that LXRβ activity up-regulated the genes involved in pro-apoptotic fatty acid production and endoplasmic reticulum stress genes and down-regulated cell cycle genes. Many of these genes …
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Charakterisierung eines neuen ATP-binding-cassette Transporters aus der ABCA-Subfamilie
… Faktoren, z.B. durch die Kulturdauer und LXR-Aktivatoren, beinflusst wird.Zur Klärung der subzellulären Lokalisation von rAbca5 wurden das vollständige Gen und die Splicevariante in Expressionsvektoren mit Epitop-Tag (V5, EGFP) eingebracht und als Fusionsproteine in verschiedenen …
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