Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"LXCXE"”.
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Characterizing the contribution of the LXCXE binding cleft to pRB-mediated genome stability and tumor suppression
… defective for interactions mediated by the pRB LXCXE binding cleft that is distinct from E2F binding (Rb1ΔL/ΔL), I have demonstrated that LXCXE-interactions are an essential part of pRB-mediated tumor suppression. When these interactions are disrupted, cells exhibit chromosome condensation and …
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Dissecting the molecular role of distinct binding interfaces on the retinoblastoma tumor suppressor in growth control and tumorigenesis.
… the regulation of E2F transcription factors, the LXCXE binding cleft and the ‘specific site’ can function redundantly to control proliferation. A gene-targeted mouse model was developed that disrupted the ‘general site’ while leaving other binding sites on pRB intact. Strikingly, these mice are …