Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"LX-2"”.
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Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
… to silence the IGFIIR expression in human HSCs (LX-2) to confirm the specificity of the identified peptide ligands. Among the identified peptide candidates, the peptide-431 shows the highest binding affinity and specificity to recombinant human IGFIIR protein and HSCs. The apparent equilibrium …
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EFFECT OF COMBINATION OF THE MAMMALIAN LIGNAN, ENTEROLACTONE, WITH TYROSINE KINASE INHIBITORS ON MARKERS OF HEPATIC FIBROSIS
… using human hepatic stellate cells (HSC), LX-2 cells, at both mRNA and protein level by real-time PCR and ELISA/western blot, respectively, demonstrated that Gefitinib had the greatest ability to attenuate HSC activation and ECM production and was chosen as the model TKI for further …
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Einfluss von Transforming Growth Factor-beta1 (TGF-[beta]1) Genpolymorphismen auf die Hepatitis-C-induzierte Leberfibrose in vivo und Modulation der TGF-[beta]1-Synthese, Prozessierung und Sekretion durch die Serin-Protease Furin, das latent TGF-[beta] binding protein-1 und Polymorphismen der TGF-[beta]1-Signalsequenz in vitro
… for furin and LTBP-1 into CHO cells or into LX-2 cells. The expression and secretion was confirmed by Western blot and quantification of Flag-eptitope tagged protein was done in ELISA. In the two cell systems, synthesis and proteolytic cleavage of TGF-beta1 were influenced differently by …
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Identifying Functional Enhancers For Fibrotic Gene Regulation In Liver Fibrosis
… to liver fibrosis. Here we used human HSC LX-2 cells after TGF-β treatment as a model, and utilized epigenetic methods such as ChIP-seq and nascent RNA-seq TT-Seq to define TGF-β activated enhancers in human HSC cells. We also identified the noncoding RNAs produced from active enhancers …
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Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis
… exhibited the highest targeting effect to human LX-2, rat HSC-T6 cell line, and activated primary rat HSCs. Accordingly, the IGF2Rspecific peptide coupled nanocomplex demonstrated higher silencing activity of PCBP2 and better inhibition on the migration of activated HSCs. The IGF2R-specific …