Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"LV remodelling"”.
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MATRIX METALLOPROTEINASES AND LEFT VENTRICLE MASS AND FUNCTION
Introduction: Left Ventricle (LV) remodelling is critical pathophysiological process in the development of heart failure. Previous published studies have suggested the pivotal role of matrix metalloproteinases and NT- pro BNP in the pathogenesis of LV remodelling. Our objective was to establish a …
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A Comprehensive Analysis of SGLT2-inhibition in Type 2 Diabetes and Heart Failure
… Effect of SGLT2-inhibiton on Left Ventricular Remodelling in Patients with Heart Failure and Diabetes Mellitus (REFORM) trial, addresses the literature gap in this area, and is the first to study the effects of SGLT2-inhibition specifically in the HF population. It showed no difference between …
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A computational study of post-infarct mechanical effects of injected biomaterial into ischaemic myocardium
… are related to ischaemic heart disease, involving a myocardial infarction (MI). Emerging MI therapies involving biomaterial injections have shown some benefits; the underlying mechanisms of which remain unclear. Computational models offer considerable potential to study the biomechanics of a …
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Pathophysiological role of aldosterone in cardiac remodelling after myocardial infarction
… of left ventricular systolic dysfunction (LVSD) following AMI increases both in-hospital and longer-term mortality. A series of structural and functional changes occur within the heart in general and within the left ventricle (LV) in particular following AMI, initially providing a …
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The safety and efficacy of novel dual function coronary stent in porcine model of myocardial infarction
… both inhibiting In Stent Restenosis (ISR) and salvaging the injured myocardium following acute myocardial infarction in pigs. Background: For more than a decade, drug eluting stents have written a successful chapter in coronary revascularisation following myocardial infarction. However, none so …
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The impact of ageing and exercise training on cardiac structure and function in healthy females
… controls. The exact nature of left ventricular (LV) remodelling with age is the source of some controversy. Within a cross-sectional design cardiac structure and function was assessed in 124 women and 74 men (18-76 years). Left ventricular mass was maintained across the adult age-span in females …
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Assessment of aortic stenosis using modern non-invasive imaging techniques
… both by progressive narrowing of the valve and the hypertrophic response of the left ventricle. The purpose of this thesis was to study the contribution of inflammation and calcification to valve narrowing using Positron Emission and Computed Tomography (PET/CT) and to investigate the …
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Functional, Structural and Molecular Alterations in the Heart and Kidney During Diabetes Mellitus
… investigated the effect of HG on left ventricle (LV) and kidney structural remodelling, function and underlying molecular events associated with the two organs over a period of 2 and 4 months compared to age-matched control. Methods: Molecular mechanisms underlying HG-induced remodelling changes …