Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"LUBAC"”.
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Direct Regulation of Apoptosis By Linear Ubiqutin Chain Assembly Complex (Lubac) and Feedback Regulation of Lubac Function By Caspases
… signaling). Recently, linear ubiquitination by LUBAC (linear ubiquitin chain assembly complex) was reported to have a regulatory function in TNF-α mediated NF-κB activation. Although LUBAC is suggested to control not only NF-kB signaling but also the apoptosis pathway, the precise mechanism of …
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LUBAC is required for the RIG-I mediated antiviral response
… of the linear ubiquitin chain assembly complex (LUBAC) to the sensing of RNA and RNA viruses by RIG-I. By using synthetic RNAs, 3p-hpRNA and Poly(I:C), and RNA viruses to specifically stimulate RIG-I, we confirmed the requirement of signalling proteins MAVS and NEMO for activation of IRF3 and …
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An investigation into the role of LUBAC and linear ubiquitin chains in antibody dependent intracellular neutralisation
Antibody dependent intracellular neutralisation (ADIN) mediates the rapid proteasomal degradation of antibody-bound viruses. It requires TRIM21, an Fc receptor and E3 ubiquitin ligase that resides in the cytosol. Binding of TRIM21 to the exposed Fc portion of an antibody that is bound to an …
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The One Table of Christ's Word and Body: the Unity of Scripture and Eucharist in Dei Verbum and its Theological Precursors
Henri de Lubac heavily impacted the Second Vatican Council, Dei Verbum in particular. De Lubac immensely contributed toward the renewal of the ancient doctrine of the One Table, especially with his eucharistic ecclesiology (that found its way into Lumen Gentium), and his retrieval of spiritual …
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The Mystery of Christ, the Mystery of the Church: Christocentrism in the Theological Visions of Georges Florovsky and Henri de Lubac
… of Georges Florovsky (1893-1979) and Henri de Lubac (1896-1991) and argues that christocentrism functions as a foundational interpretive priority for both thinkers. Rather than just an historical or methodological continuity, I argue that their shared christocentrism is reflective of a deeper …
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A Contextual Application of The Unicity and Universality of Christ in the Context of Religious Pluralism: A Lubacian Hermeneutic.
… the church and those who are not part of it, de Lubac’s response to the question is novel. His writings on the social dimension of dogma are the key to opening up a dialogue with non-Christian religions. The social dimension of dogma de Lubac saw rooted in mystery,highlighting the unique …
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Identifying TRAF1 Mutations as a Key Step to Develop a Targeted Therapy for Rheumatoid Arthritis
… the Linear-Ubiquitin Assembly Chain Complex (LUBAC). Recent work in the lab has identified the exact sites of interaction of human TRAF1 in both these pathways. This thesis aims to investigate and generate a mouse model to study the role of mouse TRAF1 downstream of TLRs and its interaction …
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The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondii
… of the linear-ubiquitin assembly complex (LUBAC). Autophagy cargo receptors, such as NDP52, p62, and Optineurin, are also recruited to the type II, intracellular parasites. Although all these recruitments were IFN-γ-dependent, the role of LUBAC and the mechanisms for its recruitment remain …
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À mes amis qui croient et à ceux qui croient ne pas croire: Natural Knowledge of God and the Propulsion of Reason in Henri de Lubac; A Re-assessment
… of God according to the thought of Henri de Lubac. In the Anglophone theological literature of the later twentieth century, a notable consensus has emerged that de Lubac’s celebrated text, Surnaturel (1946) implicitly disallows any status for natural knowledge of God in advance of the …
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OTULIN's Novel Regulatory Mechanisms in Genotoxic and Inflammatory NF-kB Signaling
… by the linear ubiquitin chain assembly complex (LUBAC) solidly facilitate NF-kB signaling transduction upon genotoxic stress. OTU deubiquitinase with linear linkage specificity (OTULIN) is known to cleave linear ubiquitin chains exclusively. The purpose of this dissertation is to investigate …
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Explaining the Role of Scripture in the Economy of Redemption as it Relates to the Theological and Hermeneutical Contributions of David Tracy, Hans Frei, Kevin Vanhoozer and Henri de Lubac
… Vanhoozer and Ressourcement theologian Henri de Lubac, it is argued, provide helpful resources for these discussions as these theologians explicitly seek to explain the role of Scripture in mediating the relationship between Christ and the Church. The dissertation suggests that examining the role …
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The Role of HOIL 1 Ubiquitin Ligase Activity in MDA5 Antiviral Signaling
… of the Linear Ubiquitin Assembly Complex (LUBAC), which consists of another E3 ubiquitin ligase, HOIP, and SHARPIN. The LUBAC has been shown to be a major regulator fo multiple immune-related responses by conjugating linear ubiquitin chains to multiple target proteins, with HOIP functioning …
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Functional analysis of Shigella encoded IpaH E3 ubiquitin ligases in cell-autonomous immunity
… ability to prevent NF-κB activation by targeting LUBAC. I found that IpaH1.4 specifically binds the LUBAC component HOIP and mediates its proteasomal degradation, thus abolishing linear ubiquitylation of bacteria and consecutive NF-κB activation via NEMO and autophagy induction via optineurin. …
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Hinduism and Christianity: Exploring the Theological Basis for Dialogue between Christianity and Hinduism in Indian accordance with the mind of Vatican II, with particular reference to the Theological method and Christology of Henri De Lubac
The ‘Other’ has always been a matter of concern from the beginning of humanity and Christians are not an exception to this. This is true at the personal, social and political level. How we treated the ‘Other’ in the history of religions gives us pause. Religious wars and the aggressive imposition …
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The ubiquitin coat of cytosol-invading bacteria
… I demonstrate that SPLINT Labelling with LUBAC induces a M1-linked ubiquitin coat on S. flexneri and mediates the recruitment of the downstream antibacterial effectors P62, OPTINEURIN, NEMO and LC3. Nevertheless, SPLINT Labelling fails to inhibit proliferation of cytosolic S. flexneri. …
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Investigation into ubiquitin signalling in response to cisplatin
… part of the linear ubiquitin assembly complex (LUBAC). LUBAC is required for innate and adaptive immunity, suppressing inflammation and the control of cell death through TNF and etoposide-induced signalling. HOIP was identified and validated as a top candidate of the siRNA screen. Within this …
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Investigating the function of TRAF1 in NF-κB activation
… the linear ubiquitin assembly complex (LUBAC). Because of the complex role of TRAF1 in NF-κB activation, it is important to isolate and study the role of TRAF1 in each of these pathways. To better understand TRAF1 and its role in NF-κB activation, our laboratory has identified the same …
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An investigation of the activation of protein kinase complexes in the MyD88 signalling network
… which indicates that the IL-1-stimulated, LUBAC (linear ubiquitin chain assembly complex)-catalysed formation of Met1-linked/linear ubiquitin (Met1-Ub) chains and their interaction with the NEMO (NF-kB essential modulator) component of the canonical IKK complex permits the TAK1-catalysed …
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Naufragar en lo infinito: La dimensión religiosa en el pensamiento de Nietzsche
… las figuras de Eugene Biser, B. Welte, Henri de Lubac y el español Olegario G. de Cardedal, como el «protestante», recurriendo a clásicos como K. Barth, W. Pannenberg o P. Tillich, y dedicando un capítulo aparte de especial importancia a la que en su día se llamó «teología de la muerte de Dios» …