Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"LUAD"”.
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Dissecting the Relationship between Mucin 5AC and the Lung/Gut Microbiome in the Pathogenesis of K-ras Mutant Lung Cancer
… its most common subtype, lung adenocarcinoma (LUAD), is the leading cause of cancer-related deaths worldwide. In LUAD patients, KRAS mutations are the most common oncogenic driver alteration. Given KRAS is upstream to many signaling pathways involved in cell survival and cytokine production, …
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Identification of genotype-specific dependencies in Keap1-deficient lung adenocarcinoma
Lung adenocarcinoma (LUAD) remains the world's leading cause of cancer related mortality with an estimated two-hundred thousand new cases arising in 2019 in the United states alone. Molecular characterization of patient tumors has identified activating mutations in the small GTPase, KRAS, …
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Applying multi-omics to detect indolent and aggressive early-stage lung adenocarcinoma
Histologic grading of lung adenocarcinoma (LUAD) is a strong predictor of outcome but can only be completed after surgical resection. Biomarkers that are predictive of indolent and aggressive LUAD grade have the potential to improve preoperative management of early-stage disease. Here, we leveraged …
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Tumour Associated Neutrophils as a Potential Biomarker for Anti-PD-1 Immunotherapy in Non-Small Cell Lung Carcinoma: An Automated Approach
… for the treatment of lung adenocarcinoma (LUAD), objective response rates are still low at around 20%. Current biomarkers are limited in their ability to stratify patients for predicting response, highlighting the need for novel biomarkers to better guide therapeutic strategies. Tumour …
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STAT3, NF-κB, and Estrogen Receptor Beta: The Balance of Inflammation in K-ras Mutant Lung Adenocarcinoma
<p>K-ras mutant lung adenocarcinoma (KM-LUAD) is a difficult-to-treat cancer subtype in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies that …
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Genetic differences in lung adenocarcinoma cells from patients of African and European ancestry
… significant disparities in lung adenocarcinoma (LUAD) genetics across distinct ethnicities, particularly focusing on African ancestry (AA) and European ancestry (EA) populations. A meticulous comparison of genetic traits within LUAD cells derived from these ethnic groups is conducted to pinpoint …
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Exploring the Role of IL-1β/IL-1R in the Pathogenesis of K-ras Mutant Lung Cancer
… with driver mutations in the K-ras oncogene (KM-LUAD). KM-LUAD progression partly occurs through activation of the NF-κB pathway initiating an inflammatory response and creating a pro-tumor microenvironment. Notably, the pro-inflammatory cytokine IL-1β a potent activator and product of the NF-κB …
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The role of long non-coding RNA LINC00673 in lung tumorigenesis
… in the progression of lung adenocarcinoma (LUAD) – the most common type of lung cancer – to improve current understanding of the disease. Using a combination of computational and wet-lab approaches, we identified LINC00673 as a potential regulator of LUAD tumorigenesis. RNA sequencing data …
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Μεταγραφωματική και επιγενετική ανάλυση μονήρων κυττάρων ασθενών με καρκίνο του πνεύμονα
Το αδενοκαρκίνωμα του πνεύμονα (LUAD) αποτελεί το συχνότερο τύπο καρκίνου του πνεύμονα με υψηλά ποσοστά θνησιμότητας παγκοσμίως. Το κάπνισμα αποτελεί τον κυρίαρχο παράγοντα κινδύνου, προκαλώντας εκτεταμένες μεταβολές στη γονιδιακή έκφραση και στα ρυθμιστικά προγράμματα των κυττάρων του πνεύμονα. Οι …
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Targeting PRMT5 impairs cancer proliferation through splicing but promotes state shifts that enable resistance and disease progression
… treatment. We show that lung adenocarcinoma (LUAD) cell lines initially respond to treatment, but resistance arose rapidly through Lamarckian induction. The resistant state is stable, but brings with it a number of collateral sensitivities, including to the chemotherapeutic paclitaxel. Both …
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Text Prompt-Driven Medical Image Segmentation
… the second-best approach by 1.75% on LUAD-HistoSeg and 1.58% on BCSS-WSSS. Building upon this, the third study introduces a novel two-stage weakly supervised framework. In the first stage, coarse pseudo masks are generated using image-level labels and enhanced by a channel reactivation …
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Alveolar stem cell dynamics and regulatory mechanisms in homeostasis and early oncogenesis
Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality worldwide, yet the cellular dynamics and molecular mechanisms governing tumour initiation and progression remain elusive. Although alveolar type II (AT2) cells, which act as stem cells in the alveolar epithelium, have been …
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Investigation of KimiaNet's and DenseNet's deep features in lung cancer subtypes
… correlations with either lung adenocarcinoma (LUAD) or lung squamous carcinoma (LUSC). A deep feature-specific visualization technique was proposed for analyzing deep features at WSI-level. These prominent deep features were also generalizable to cancers of other organs, namely kidney and …
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Investigating The Impact of Intragenic Dna Methylation On Gene Expression, and The Clinical Implications On Tumor Cells and Associated Stroma
… It is significantly overexpressed in KIRC and LUAD, and has a z-score of 4 in KIRC, meaning that high expression of <em>CARD11</em> in this tumor type was associated with lower patient overall survival. Contrary to its canonical function in lymphocyte NF-kB activation, <em>CARD11</em> activates …
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Analysis of Meiotic Cancer Testis Antigens and Their Contribution to Tumorigenesis
… for protecting stalled DNA replication forks in LUAD. Loss of HORMAD1 leads to nascent DNA degradation, an event which is mediated by the MRE11-DNA2-BLM pathway. Moreover, following exogenous induction of DNA replication stress, HORMAD1 deleted cells accumulate single stranded DNA (ssDNA). We …
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Interrogation of Changes in Cell State during Tumor Evolution of a Genetically Engineered Mouse Model of Lung Adenocarcinoma
… engineered mouse models of lung adenocarcinoma (LUAD), tumors become more heterogeneous and dysregulate cell identities as they progress and evolve. In this thesis, single-cell RNA-sequencing technology was utilized to understand dynamic changes that occur during tumor evolution both with respect …
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Characterization of The Growth Factor Receptor Network Oncogenes in Lung Cancer
… were predicted in 541 lung adenocarcinoma (LUAD) tumors acquired from The Cancer Genome Atlas (TCGA). Each gene signature underwent validation using proteomics data from The Cancer Proteome Atlas (TCPA) and gene expression. Following thorough analysis, optimal gene signatures were determined …
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Computational Genomic Models For Spatio-Temporal Investigation of Early Lung Cancer Pathology
… NSCLCs primarily comprise adenocarcinomas (LUAD) and squamous cell carcinomas (LUSC). Advances in early detection and prevention have been limited by the lack of early-stage biomarkers and targets. A comprehensive molecular characterization of premalignant lesions and tumor-adjacent normal …
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Role of Phosphorylated Dicer1 In Tumor Progression
… DICER1.</p> <p>In human lung adenocarcinomas (LUADs), I find that the expression of phosphorylated nuclear DICER1 in an advanced tumor coincides with the expression of gastric genes. In addition, using immunohistochemistry, I show that moderate to high rate of phosphorylated DICER1 positivity …