Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"LTD4"”.
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Effect of Cysteinyl Leukotriene D4 on Chemokine Expression via Cysteinyl Leukotriene Receptor 1 in Human Lung Epithelial Cells, A549
… Cysteinyl leukotrienes (CysLTs) such as LTC4, LTD4 and LTE4 are proinflammtory lipid mediators synthesized by the 5-lipoxygenase pathway from arachidonic acid and play important roles in eosinophilic chemotactic activity to airway inflammation characterized by bronchoconstriction, mucus …
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Studies on the effect of cysteinyl leukotrienes on human t cell differentiation and function
… of potency similar to that reported for CysL R (LTD4>LTC4>LTE4). This profile of leukotrienes responsiveness was blocked using the known selective CysLTiR antagonists MK571, Montelukast and Zafirlukast. Additionally, the LTD4-induced signalling in Th2 cells is mediated via CysLTiR coupled to Gaq …
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The Role of Inflammatory Lipid Mediators on Colon Cancer Initiating Cells (CICs)
… the role of eicosanoids – leukotriene D4 (LTD4) or prostaglandin E2 (PGE2) – on CIC properties and changes occurring in the tumor environment that could possibly support CIC-induced tumor growth. To this end, we identified the CICs on the basis of ALDH expression and evaluated their in …
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Role of ß-catenin and Leukotriene in Colon Cancer Progression
… of the pro-inflammatory mediator leukotriene D4 (LTD4) in association with its receptor CysLT1 goes with poor prognosis for colon cancer patient. It is therefore of interest to further investigating the effect of LTD4/CysLT1R in tumor progression. The aim of my thesis was to investigate the role …
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Signalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells
… The cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4 are inflammatory mediators that can bind to four known receptors, two of which are the CysLT1R and CysLT2R. Inhibitors of the CysLT1R are currently used in the clinic as asthma medication. LTD4 has been shown to induce cell …
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MEDIATORS OF ACUTE INFLAMMATION AND THEIR ROLES IN MODULATING IN VI3^ LEUKOCYTE INFILTRATION AND PATHOBIOLOGIC ACTIVITY IN THE CONJUNCTIVA
… with Type I allergy. The peptide-containing LTs, LTD4 and LTE4, elicited dose-dependent and exclusively eosinophilic conjunctival infiltrates. Infiltrating eosinophils appeared intact and no instances of epithelial damage were ever observed in LT-treated tissues. LTB4 proved to be less potent in …
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Crosstalk between colorectal cancer cells and tumour-associated macrophages
… secreted high levels of IL-8 and leukotriene D4 (LTD4), which induced colon cancer cell migration, and Th2 cytokines (IL-4, IL-10) to maintain a tumoral immunosuppressive environment. Remodelling of extracellular matrix (ECM) occurs in CRC. CD47 binding to α2β1 integrin could regulate …
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The role of CysLT1R in animal models of colorectal cancer
Cysteinyl leukotrienes (LTC4, LTD4 and LTE4) are potent pro-inflammatory lipids derived from arachidonic acid and mediate their effect through CysLT1R and CysLT2R. There is a strong correlation between long-standing inflammatory bowel disease where these pro-inflammatory mediators are abundant and …
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Involvement of eicosanoid signalling in epithelial cell migration
… stimulation, with the eicosanoid leukotriene D4 (LTD4) or indirectly through inducing cyclooxygenase-2 (COX-2; an enzyme involved in the production of various eicosanoids) expression, by activating integrin collagen receptors. We observed that direct stimulation with LT D4, induced intestinal …
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Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer
… main findings have been that 1) Leukotriene D4 (LTD4) induces intestinal epithelial cell proliferation by activating the mitogenic JNK / AP-1 pathway; 2) The mitogen EGF, involved in cancer progression, down-regulates CysLT2R expression and is inversely correlated with CysLT2R in a colorectal …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes and mycobacterium tuberculosis infections in mice
… in LTB4 and cysteinyl LTs (cysLTs; LTC4, LTD4 and LTE4). CysLTs, which are pro-inflammatory lipid mediators, play a role in asthma and interact with three G-protein-coupled receptors (CysLTR1, CysLTR2, and GPR99). While the role of CysLTR1 and its ligand has been studied in asthmatic and …
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Cysteinyl leukotriene receptor 1 as a host determinant for susceptibility to cutaneous leishmaniasis in a mouse model
… consist of cysteinyl leukotrienes (CysLTs- LTC4, LTD4, LTE4) and LTB4, it is unclear which LT subclass is responsible for this protection. Recent studies suggested treatment of cutaneous leishmaniasis infected animals with cysteinyl leukotrienes induce host protection. To investigate this further, …