Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"LTB4"”.
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Development and application of monoclonal antibodies in studies of the human leukotriene B4 receptor, BLT1
… system. One of these important mediators is LTB4, an arachidonic acid derivate that attracts e.g. monocytes and granulocytes to inflammatory sites and induces phagocytosis and degranulation. LTB4 binds to BLT1 which is a 7-transmembrane receptor that belongs to the superfamily of G …
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Understanding how neutrophils self-organise their migration to sites of inflammation in vivo
… production, notably of the lipid leukotriene B4 (LTB4). The decision to release attractants at the single-cell level is important and impacts the magnitude of the entire immune response. However, the precise mechanisms triggering this decision remain unclear. In this study, I employed in vivo …
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Role of the Leukotriene B4 Metabolic Pathway in Human Pancreatic Cancer
… and anaphylaxis. Among them, leukotriene B4(LTB4) is one of the final products of the 5-LOX pathway of arachidonic acid metabolism and it has been widely implicated in the pathogenesis of several inflammatory diseases, such as asthma, psoriasis, rheumatoid arthritis and inflammatory bowel …
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MEDIATORS OF ACUTE INFLAMMATION AND THEIR ROLES IN MODULATING IN VI3^ LEUKOCYTE INFILTRATION AND PATHOBIOLOGIC ACTIVITY IN THE CONJUNCTIVA
… damage were ever observed in LT-treated tissues. LTB4 proved to be less potent in causing cellular infiltration, into the conjunctiva. The slow-reacting substance of anaphylaxis (SRS-A) antagonist, FPL 55712, and the potent and selective peptide-LT antagonist, SK&F 104353, abolished conjunctival …
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Effect of atorvastatin on asthma control and airway inflammation: a randomised controlled trial
… IL-5, IL-8, sICAM-1, TNF-α, leukotriene B4 (LTB4) and high sensitivity C-reactive protein (hsCRP), and blood lymphocyte proliferation. Results At 8 weeks, the change in mean morning PEF, as compared with baseline, did not differ between the atorvastatin and placebo treatment periods [mean …
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The Immune Modulatory Effects of Tylvalosin in Porcine Neutrophils and Macrophages in vitro
… mediators in stimulated neutrophils (LTB4) and in stimulated macrophages (CXCL8 and IL-1α). Together, these findings demonstrate that tylvalosin has immuno- modulating properties in vitro, including the induction of leukocyte apoptosis, the inhibition of pro-inflammatory cytokines and …
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Microfluidic platforms for studying cell behavior
… gradients of the intermediary chemoattractants LTB4 and IL-8. In the opposing linear gradients, neutrophils exhibited an oscillatory behavior migrating between the two chemoattractant maxima. Finally, a microfluidic platform to study intercellular signaling via diffusible molecules was developed …
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Investigating Pulmonary Immune Responses that Detect and Counteract Gram-negative Bacterial Infections
… swarming and clustering, which preceded LTB4 dependent immunothrombosis. These immunothrombi trapped bacteria and promoted platelet dependent microbial resistance but also caused lethal vascular occlusions. Cathelicidin deficiency impaired this host defence mechanism leading to bacterial …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes and mycobacterium tuberculosis infections in mice
… via 5- lipoxygenase metabolism, resulting in LTB4 and cysteinyl LTs (cysLTs; LTC4, LTD4 and LTE4). CysLTs, which are pro-inflammatory lipid mediators, play a role in asthma and interact with three G-protein-coupled receptors (CysLTR1, CysLTR2, and GPR99). While the role of CysLTR1 and its …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes infection in mice
… lipoxygenase-metabolism of arachidonic acid to LTB4 and cysteinyl LTs (cysLTs). CysLTs are pro-inflammatory lipids that have pathobiological functions in asthma. CysLTs function through three G-protein coupled receptors (CysLTR1, CysLTR2 and GPR99). The CysLTR1 and its ligands function has been …
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Cysteinyl leukotriene receptor 1 as a host determinant for susceptibility to cutaneous leishmaniasis in a mouse model
… leukotrienes (CysLTs- LTC4, LTD4, LTE4) and LTB4, it is unclear which LT subclass is responsible for this protection. Recent studies suggested treatment of cutaneous leishmaniasis infected animals with cysteinyl leukotrienes induce host protection. To investigate this further, we targeted …
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Untersuchung der Genexpression von ABC- und SLC-Transmembranproteinen mit Beteiligung am aktiven Transport von Antigenen, Eikosanoiden und Zytostatika beim malignen Melanom
… is mediated by MRP4 (e.g. PGE2, LTB4), MRP1 (LTC4) and OATP3A1 (PGE2). There is growing evidence that these lipids play a key role in cell proliferation and migration. Showing the mRNA expression of efflux and influx transporters, we provide data that strongly support the …
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Changes in tear film biochemistry in end of day ocular discomfort with and without contact lenses
… film, but certain components such as PIP and LTB4 may be partly related to comfort during CL wear.
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The central role of the neutrophil in ischaemic/reperfusion injury
… of events. Lesser roles for IL-8, TNF and LTB4 were also suggested. The secretory products from hypoxia/reoxygenated endothelial cells also affected smooth muscle contractility having an anti-vasoconstrictor or relaxation property, similar to that exerted by PAF.
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A Mathematical-Experimental Strategy to Decode the Complex Molecular Basis for Neutrophil Migratory Decision-Making
… between an end-target (fMLP) and intermediary (LTB4) chemoattractant. Additionally, we probed for the expression level of molecules related to neutrophil chemotaxis. We also built a system of ordinary differential equations to model the dynamics of the molecular interactions underlying …
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Microfluidic platforms for studying cell behavior in complex microenvironments
… maxima of the two intermediary chemoattractants LTB4 and IL-8. Chapter 3 discusses the design and characterization of a microfluidic platform with barriers that act as bifurcations in the path of neutrophil migration. Neutrophils were found to efficiently migrate around 40-μm and 100-μm wide …
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Neural and Behavioural Consequences of Chronic Inflammation following Spinal Cord Injury
… prostaglandin E2 (PGE2) and leukotriene B4 (LTB4). In addition to such molecular indices, actual changes in each of the outcome variables of interest were assessed. Levels of depression were assessed by questionnaire via the Center for Epidemiological Studies Depression Scale (CES-D). …
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Harnessing Systems Bioengineering Approaches to Study Microbe-Microbe and Host-Microbe Interactions in Health and Disease
… interleukin-6 (IL-6), but not leukotriene B4 (LTB4), compared to the infection alone. Our device platform is unique in that the nanoliter well-assisted individual neutrophil trapping enables us to quantify NET release with single-cell precision. Besides, incorporating confined side loops in the …
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Neutrophil Chemotaxis in Multiple Chemoattractant Gradients
Chemotaxis, the phenomenon in which cells move in response to extracellular chemical gradients, plays a prominent role in the mammalian immune response. During this process, a number of chemical signals, called chemoattractants, are produced at or proximal to sites of infection and diffuse into the …