Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"LSD1"”.
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Molecular and Genetic Analysis of Novel Epigenetic Silencing Factors Dhp1, Lsd1, and Lsd2
… complex member Ipi1, and histone deacetylases Lsd1 and Lsd2. We are however able to identify previously unreported genetic interactions between SPAC25G10.01Δ and mutants of histone deacetylases Clr3 and Sir2. We also generate novel lsd1 and lsd2 mutants for these analyses, which reveal a role …
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Targeting Unique Domains of Lsd1 Regulates Pediatric Glioma Innate Immunity and Nk Cell Metabolism
… in this cancer. The histone demethylase LSD1 (also known as KDM1A, BHC110, and KIAA0601) has been revealed as a promising target in leukemias and viii pediatric sarcomas, but its validity as a cancer target in pediatric glioma is unknown. LSD1 can be inhibited by small molecules with …
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TARGETING METABOLIC PLASTICITY OF GLIOBLASTOMA TUMOR INITIATING CELLS TO RESTORE SENSITIVITY TO LSD1-DIRECTED THERAPY
… shown that Lysine Specific Demethylase 1 (LSD1) genetic and pharmacological inhibition employing the selective LSD1 inhibitor (LSD1i) impairs TICs ability to restore homeostasis after ER stress or nutrient starvation by hindering a proper Activating transcription factor 4 (ATF4)-dependent …
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Histone Demethylase LSD1 Restricts the Size of the Germline Stem Cell Niche in Drosophila Ovaries
… of germline stem cells (GSCs). Mutations in Lsd1, a histone demethylase exhibit GSC-like tumor formation. Clonal analysis, cell-type specific knock down and rescue experiments demonstrate that Lsd1 functions within the escort cells that reside immediately adjacent to cap cells (niche). Loss …
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Pharmacological Inhibition of LSD1/KDM1A in Diffuse Midline Glioma Models and Impact on Kinase Signaling
… modulator, lysine specific demethylase 1 (LSD1) is a histone demethylase. It’s function demethylates mono- and di-methyl marks on H3K4 and H3K9 residues. This demethylase activity can impact gene transcription and overall gene expression, where dysregulated LSD1 expression has been found to …
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Efforts to Elucidate the Binding Interaction between Lysine-Specific Demethylase 1 (LSD1/KDM1) and CoREST and Their Roles in Breast Cancer
… demethylases. Lysine specific demethylase 1 (LSD1) is a unique histone demethylase that removes methyl groups on lysine residues and mediates expression of many genes important in cancer progression. LSD1 activity and its substrate specificity are mainly regulated by association with a number …
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ROLE OF THE HISTONE DEMETHYLASE LSD1 IN THE REGULATION OF DIFFERENTIATION OF ACUTE PROMYELOCYTIC LEUKEMIA CELLS
… in the APL pathogenesis also interact with LSD1 in other systems. LSD1 is a demethylase involved in transcriptional regulation, mainly acting on dimethylated lysine 4 of Histone H3 (H3K4me2). We showed that LSD1 inhibition sensitizes an APL cell line to physiological RA concentration. Here …
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Combined Inhibition of Lysine-Specific Demethylase 1 and Kinase Signaling as a Preclinical Treatment Strategy in Glioblastoma
… a poor prognosis. Lysine-specific demethylase 1 (LSD1) is overexpressed in glioblastoma and contributes to tumor growth and treatment resistance. Inhibitors of LSD1 have shown preclinical promise but have had limited clinical development for glioblastoma. Given the frequent kinase pathway …
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A CELL CYCLE CLOCK REGULATES THE EPIGENETIC LANDSCAPE OF AML CELLS AND DETERMINES SENSITIVITY TO LSD1 INHIBITION
… and treatment, focusing on the epigenetic enzyme LSD1, which is regularly found overexpressed in AML, as a therapeutic target. We revealed a crucial role for the cell cycle regulator p21 in determining sensitivity to LSD1 inhibition. Our findings further demonstrate that pharmacological …
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ALTERNATIVE SPLICING AND PHOSPHORYLATION PROVIDE A MECHANISTIC BASIS FOR FUNCTIONAL SPECIALIZATION OF LSD1/KDM1 HISTONE DEMETHYLASE IN THE CENTRAL NERVOUS SYSTEM
… variants of the histone demethylase LSD1 / KDM1 arising from combinatorial retention of two alternatively spliced exons, resulting in either ubiquitous isoforms or neuro-restricted ones, which are dynamically regulated during cortical development. The neuro-specific variants, whose …
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Crystal Structure and Mechanism of Lysine Specific Demethylase-1
… tails is crucial in epigenetic gene regulation. LSD1, the first known lysine-specific demethylase, selectively removes monomethyl and dimethyl, but not trimethyl modifications of Lys4 or Lys9 of histone-3. Here, we present the crystal structure of LSD1 at 2.9-A resolution. LSD1 forms a highly …
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Mechanisms and Targeting of Neurodevelopmental Regulator Rest In Medulloblastoma Dissemination
… cofactor, lysine specific demethylase 1 (LSD1). To this end, I examined human MB patient samples for LSD1 expression and discovered that while CXCR4 signaling was highly relevant to SHH-beta subgroups, LSD1 was increased in the context of REST most strongly in SHH-alpha and SHH-beta …
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A SEARCH FOR EPIGENETIC VULNERABILITIES OF AML CELLS PERFORMED BY A CDK INHIBITOR¿BASED CRISPR SCREENING
… strategy. Among these, the histone demethylase LSD1/KDM1A has been extensively studied, yet clinical responses to LSD1 inhibition remain variable. Work from our group demonstrated that pharmacological prolongation of the G1 phase of the cell cycle through sub-optimal doses of CDK4/6 inhibitors …
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Trim24-Regulated Estrogen Response Is Dependent On Specific Histone Modifications In Breast Cancer Cells
… transcription.</p> <p>Therefore, when LSD1-mediated demethylation of H3K4 is inhibited, activation of</p> <p>TRIM24-regulated ERα target genes is greatly impaired. Importantly, I</p> <p>demonstrated that TRIM24 and LSD1 are cyclically recruited to estrogen</p> <p>responsive elements …
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Simulating biochemical physics with computers
… dynamics of lysine-specific demethylase (LSD1) in complex with CoREST and protein-substrate interactions of LSD1 with histone H3 tail. MD simulations of LSD1•CoREST complex bound to a 16 a.a. of the Nterminal H3-tail peptide (H3-p16) were carried out using NAMD to study the conformational …
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Characterisation of oncogenic pathways driving the pathogenesis of prostate cancer
… that TBX2 interacts with CoREST complex members LSD1 and ZNF217 and ChIP qPCR confirmed TBX2 shRNA reduced ZNF217 recruitment to E-cadherin and NDRG1 promoters. In accordance, targeting the LSD1/ZNF217 interaction via an allosteric LSD1 inhibitor phenocopied TBX2 knockdown in PCa cells. Effects …
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Lysine Specific Demethylase-1 and the Brahma Chromatin Remodeling Complex Regulate Conserved Signaling Pathways During Drosophila Wing Development
… I identified Lysine Specific Demethylase-1 (LSD1) as a potential co-regulator of a subtype of Brahma complex, the PBAP complex, remodeling activities. I found that LSD1 has an important role in cell-fate determination during pupal wing development. Mutation or loss of Co-RE1 Silencing …
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Flavin Amine Oxidases from the Monoamine Oxidase Structural Family Utilize a Hydride Transfer Mechanism
… (PAO) and human lysine specific demethylase (LSD1), to determine the mechanisms of amine oxidation. PAO is a flavin adenine dinucleotide (FAD)-dependent enzyme that catalyzes the oxidation of N1-acetylated polyamines. The pH-dependence of the kcat/Kamine indicates that the monoprotonated form …
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Understanding the Role of Delta-catenin in Virus-Positive Merkel Cell Carcinoma
… that lysine-specific histone demethylase 1A (LSD1/KDM1A) regulates delta-catenin isoform 3 expression by modulating Epithelial Splicing Regulatory Protein (ESRP1), a delta-catenin splicing factor and epithelial marker. Taken together, this work reveals novel host factors involved in MCPyV …
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