Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"LRP6"”.
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LOCALIZED WNT3A-SOURCES INSTRUCT MITOTIC ORIENTATION: DISSECTING THE WNT3A-TRANSDUCTION MECHANISM COUPLED WITH NUMA MACHINERY
… revealed that canonical Wnt effectors including LRP6, β-catenin, DVL2 and Cav1 are implicated in the spindle axis alignment towards the Wnt3a source. In addition, we demonstrate that Gai/LGN/NuMA complexes at the cell cortex together with astral MTs, are essential for Wnt3a-dependent spindle …
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A novel in vivo protein refolding technique
… domain I of LDL receptor-related protein 6 (BP1-LRP6) and the ligand-binding domain of apolipoprotein E receptor 2 (LBD-ApoER2). These two proteins contain a large number of cysteines that form intracellular disulfide bonds. The folding of these two proteins is very challenging. I performed …
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The cellular and molecular investigation of Wnt/FZD signalling during spinal cord neurogenesis
… transduction and for spinal cord development. Lrp6 is involved in central nervous system development including spinal cord. In this study, in vivo experiments revealed that Lrp6 complements Wnt1/FZD10 mediated activation of dorsal markers during spinal cord neurogenesis. This could explain how …
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Genetic Pathway Analysis of Abnormal Facial Development In Nonsyndromic Cleft Lip and Palate
… variants in<em> FZD6</em>, <em>LRP5</em>, <em>LRP6</em> and <em>DKK1 </em>driving allele-specific expression during craniofacial development. Testing of these variants in our extensive family-based NSCLP dataset identified, for the first time, associations between <em>LRP5</em> and …
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Functional Analysis Of A Highly Conserved Cyclin, Cyclin Y, In Drosophila Melanogaster
… of the wingless/Wnt co-receptor, arrow/LRP6, and for full activation of the canonical wingless/Wnt pathway. CycY null Drosophila, however, do not phenocopy loss-of-function mutations in canonical wingless pathway genes, suggesting that Cyclin Y may have additional roles outside the …
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Engineering Tools to Promote and Characterize Wnt-Mediated Stem Cell Differentiation
… of Fabs which bind to the Wnt co-receptors LRP6 and Frizzled. We have shown that this dimer can activate Wnt signaling with an efficacy comparable to that of the natural ligand. To elucidate the mechanisms of downstream events in the Wnt pathway, we constructed a kinetic model consisting of …
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Functional Analysis of the Tumor Metastasis Suppressor, NDRG1
… that NDRG1, interacts with the Wnt receptor, LRP6, followed by blocking of the Wnt signaling, and therefore, orchestrates a cellular network that impairs the metastatic progression of tumor cells in vitro and in animal model. We also found that restoring NDRG1 expression by a small molecule …
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Optogenetic control of developmental signaling pathways
How a complex multicellular organism forms from a single cell is a question that defies simplistic understanding. Yet, embryonic developmental programs use a surprisingly small set of signaling pathways to pattern the embryonic tissue into germ layers from which the various tissues and organs …