Global ETD Search
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Showing 1 to 7 of 7 for “"LRP4"”.
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Ανασυνδυασμένες πρωτεΐνες της νευρομυϊκής σύναψης και χρήση τους στην ανάπτυξη διαγνωστικών μεθόδων για τη μυασθένεια
… 80-85% των ασθενών, η MuSK σε ποσοστό 5-7% και η LRP4 σε ποσοστό 2-3%. Παρά την εκτεταμένη έρευνα, το ποσοστό των οροαρνητικών μυασθενών (SN-MG), δηλαδή ασθενών που δεν φέρουν αντισώματα για κανένα από τα ήδη γνωστά αντιγόνα, αποτελεί ένα σοβαρό κενό για την πλήρη κατανόηση της νόσου. Το γεγονός …
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Neuromuscular Synaptic Proteins In Development And Regeneration
… neuromuscular synapses form through the Agrin-Lrp4-MuSK signaling pathway that clusters acetylcholine receptors beneath motor axon terminals, yet in vivo role of this pathway in peripheral nerve regeneration has not been examined. To determine whether this pathway is employed during …
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Low-Density Lipoprotein Receptors in Signaling Modulation and Development
… have been greatly expanded. LRP1, LRP1b and LRP4 are gene family members that are implicated in the regulation of signaling pathways at the intracellular, extracellular and transcriptional level. These regulations confer viability, control the cellular proliferation at several molecular …
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The Role of Wnt Signaling in Bone Mechanotransduction
… lipoprotein receptor-related receptor 4 (Lrp4), in the regulation of bone mass and mechanotransduction. I generated an Lrp4 knockin mouse model harboring a missense mutation found among human patients with abnormally high bone mass. I hypothesize that the mutation compromises sclerostin …
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Tumor Necrosis Factors and Chemokines in Hair Development
… some Wnt pathway members, such as Dkk4 and Lrp4,TNF family member A20, and two chemokines, cxcl10 and cxcl11, as likely direct target genes of Eda. It is shown that whereas Dkk4 and Lrp4 are expressed in all ectodermal organs, A20 and the two chemokines seem to be hair follicle specific. …
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Analysis of the Function of Megf7 During Development
Lrp4/Megf7, a member of the low-density lipoprotein receptor gene family, is a major regulator of tissue patterning during embryonic development. Prior to this work, the function Megf7 had largely been unknown. Eight distinct mutations in Megf7 were introduced into mice in order to facilitate a …
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The effect of whey protein-polyphenol on the recovery of muscle function and strength following eccentric exercise- the myogenic and neural contributions to eccentric exercise.
… expression of genes associated with the agrin-LRP4-MuSK signalling pathway and muscle mass regulation (i.e. mTOR), with limited expression of muscle injury-associated genes. Finally, we investigated whether a combined protein-polyphenol supplement enhanced recovery from resistance-type exercise …