Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"LRP1"”.
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THE RNA-BINDING PROTEIN LRP1 MEDIATES FLOWERING TIME IN ARABIDOPSIS
… show that LATE FLOWERING RNA-BINDING PROTEIN 1 (LRP1), an RNA-binding protein, promotes flowering through modulating <i>FLC</i> mRNA levels. <i>LRP1</i> mRNA is highly expressed in shoot apices and young leaves, while its protein is localized in the cytoplasm and nucleus. <i>lrp1</i> mutants show …
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Role of Hepatic Lipoprotein Receptor-related Protein 1 (LRP-1) on Amyloid Beta Pathology in a Mouse Model of Amyloidosis
… lipoprotein receptor related protein-1 (LRP1) which is the major receptor involved in the peripheral clearance of Aβ. Our preliminary work on the same lines showed a reduction in hepatic LRP1 in alcohol-fed mice with a concomitant increase in brain Aβ. Therefore, we hypothesized that a …
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Low-Density Lipoprotein Receptors in Signaling Modulation and Development
… of functions have been greatly expanded. LRP1, LRP1b and LRP4 are gene family members that are implicated in the regulation of signaling pathways at the intracellular, extracellular and transcriptional level. These regulations confer viability, control the cellular proliferation at several …
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Germline Genetic Modulator of Cancer Metastasis
… proliferative competence by targeting tumoral LRP1 receptors, which signaled to the nucleus and repressed metastasis-promoting genes XAF1 and USP18. Mechanistically, the V474I mutation may enhance PCSK9's suppression of LRP1 by increasing its binding affinity. Antibody-mediated therapeutic …
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A Gain-of-Function Role of Apolipoprotein E2 in Melanoma Progression
… cell-specific deletion of the APOE receptor LRP1 in the genetic mouse model abolished differences in tumor growth, metastasis, and protein synthesis between the APOE2 and APOE4 genotypes, thus revealing a melanoma cell-intrinsic APOE2/LRP1 axis that serves to promote melanoma progression. …
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Microglial Phagocytosis of Bacteria and Synapses
… or by blocking microglial receptors MerTK or LRP1. LPS-activated microglia phagocytosed more E. coli than unactivated microglia, and this phagocytic induction was inhibited by an antibody against calreticulin, sugars, blocking MerTK or LRP1, or simply exchanging the cellular media. Thus, …
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The Development of a Drug Delivery System Using Brain Endothelial Non-Antibody Binding Domains as Transport Carriers
… lipoprotein-related receptor protein 1 (LRP1) were characterised for use as selectable targets on the cell surface of Immortalised human brain endothelial cells (hCMEC/D3) by flow cytometric analysis. Aptamers and cyclic peptide domains were then selected via <i>in vitro</i> selection …
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The Mechanisms of Tau Entry to the Cytosol
… between tau assemblies, surface receptor LRP1 and heparan sulphate proteoglycans promote the uptake of tau assemblies to membrane-bound vesicles. A subsequent escape from these vesicles is postulated for assemblies to enter the cytosol and contact cytosolic tau pools to induce seeded …
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Identification of a MicroRNA Network that Regulates Melanoma Metastasis and Angiogenesis by Targeting ApoE
… on metastasis: ApoE acting on melanoma cell LRP1 receptors inhibited melanoma invasiveness, while ApoE acting on endothelial cell LRP8 receptors suppressed metastatic endothelial recruitment (MER). In light of ApoE's key metastasis-suppressive role, we next investigated therapeutic approaches …
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ROLE OF HIGH DENSITY LIPOPROTEINS AGAINST PROSTATE CANCER
… revealed that PCa cells overexpress LDL-R and LRP1, suggesting a reliance on extracellular cholesterol uptake rather than de novo synthesis. This is supported by functional data showing that HMG-CoA reductase inhibition did not alter cellular cholesterol levels in PC3 cells, and by scRNA-seq …