Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"LQTS"”.
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“Am I going to die today?” An investigation into the psychosocial impact of Long QT Syndrome, healthcare experiences and the genetic testing process
Background: LQTS is an inherited cardiac condition that imposes serious risks, including sudden death, and a restricted lifestyle. The limited international research on psychosocial responses to the condition, and to the genetic testing process, indicates high levels of anxiety and depression, …
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Genetic Variants and Risk in Sudden Cardiac Death Syndromes
… basis, including for example long QT syndrome (LQTS) and hypertrophic cardiomyopathy (HCM), and clinicians strive to identify the patients at highest risk of SCD events. Incomplete penetrance and variable expressivity even amongst individuals with the same diseasecausing mutation indicates the …
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Human Nav1.5 F1486 deletion associated with long-QT syndrome leads to deficiency in inactivation and reduces lidocaine sensitivity
… been well documented to cause long-QT syndrome (LQTs) by disrupting channel inactivation and increasing late sodium current. Previous studies have revealed the importance of the intracellular loop region between transmembrane domain III and IV of sodium channel α subunit in regulating the fast …
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Febrile Temperature Facilitates Degradation of Human Ether-a-Go-Go-Related Gene (hERG) Channels
… effects can lead to long QT syndrome (LQTS), predisposing affected individuals to cardiac arrhythmias, syncope, and sudden death. Recently, studies have reported roles for fever in triggering QT prolongation and life-threatening cardiac arrhythmias in patients with congenital hERG …
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Investigating the novel interaction between hERG and the Fc region of IgG and its consequences
… for the form of acquired long QT syndrome (LQTS) observed in certain autoimmune patients. Previously, our lab identified the autoantibody anti-Ro52 to interact with hERG and reduce its expression on the cell surface, however the exact mechanism for this is not well characterized. Here, …
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Referral Patterns and Utilization of Clinical Genetic Testing For Patients With Inherited Cardiac Disease
… cardiomyopathy (HCM) and long QT syndrome (LQTS). The majority of participants in this study responded that they never or rarely utilize genetic testing (81%, n = 17) and they felt that uncertainties concerning where and how to obtain genetic testing coupled with cost and medical management …
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Functional and Biochemical Characterization of KCNQ1/KCNE1 Subunit Interactions in the Cardiac IKs Potassium Channel
… syndromes, including long QT syndrome (LQTS), short QT syndrome (SQTS) and familial atrial fibrillation (FAF). The biophysical properties of IKs channel current are dramatically altered when KCNE1 associates with the KCNQ1 channel. Functional tetrameric channels can be formed by KCNQ1 …
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Athletes heart and exercise related sudden cardiac death: Across the age span
… of <500 ms had any other features to indicate LQTS. Accordingly, the prevalence of a prolonged QTc interval in elite British athletes is 0.4%. 3) Study 6 examined 300 nationally ranked UK black male athletes (mean age 20.5 years) in comparison to 150 black and white sedentary individuals and …