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Showing 1 to 20 of 96 for “"LPA"”.

  1. The Biochemical Pathway Leading to Lpa Generation Upon Blood Coagulation

    Bolen, Alyssa Lynn Jefferson2016

    … upsurge in 18:2 and 20:4 lysophosphatidic acid (LPA) production. The biochemical pathway responsible for LPA production during blood clotting is not fully understood. We have purified a phospholipase A<sub>1</sub> (PLA<sub>1</sub>) from thrombin-activated human platelets using sequential …

    tenn-hsc Repository record

  2. Oncogenic Signaling Pathways Activated by Lysophosphatidic Acid (LPA) in Ovarian Carcinoma

    Goldsmith, Zachariah G.Temple University. Libraries2009

    … remain poorly defined. Lysophosphatidic acid (LPA) has emerged as a biomarker present in the ascitic fluid and serum of ovarian cancer patients. Subsequent studies have identified LPA as an agonist for G protein coupled receptors (GPCRs). LPA has been well characterized as a pro-migratory …

    temple Repository record

  3. The hypoxic tumor microenvironment regulates the LPA signaling axis to promote cancer cell invasion and metastasis

    Harper, KellyUniversité de Sherbrooke2018

    … demeurent méconnus. La signalisation du LPA joue un rôle important au cours de la tumorigenèse et du développement des métastases, les membres de cette voie étant souvent régulés à la hausse dans les cellules tumorales. La signalisation du LPA a également été impliquée dans la production …

    sherbrooke Repository record

  4. CROSSTALK BETWEEN LYSOPHOSPATIDIC ACID (LPA) AND TRANSFORMING GROWTH FACTOR BETA (TGFβ) IN BREAST AND OVARIAN CANCER CELLS

    Wu, Jinhua2017

    <p>Lysophosphatidic acid (LPA) and transforming growth factor beta (TGFβ) are platelet-derived intercellular mediators of cell proliferation and motility. LPA is a general growth, survival and motility-stimulating factor in mammalian cells. TGFβ prevents proliferation of normal epithelial cells. …

    vcu Repository record

  5. ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM

    Mukherjee, Abir2017

    … simplest phospholipid, lysophosphatidic acid (LPA), is a heat stable component of serum known for its proliferative and migratory activities in cancer cells. Strong evidence suggests that LPA production and expression of its receptors are dysregulated in multiple human malignancies. The …

    vcu Repository record

  6. Role of the LPA2 Receptor in Protecting Against Apoptosis

    E, Shuyu2016

    <p>Lysophosphatidic acid (LPA) is a naturally occurring lipid mediator. It exists abundantly in biological fluids such as serum, saliva, follicular fluid, seminal fluid and malignant effusions and induces a vast array of biological responses affecting cell growth, survival, differentiation, …

    tenn-hsc Repository record

  7. DIFFERENTIAL EFFECTS OF GROWTH FACTORS ON GLYCOLYSIS IN OVARIAN CANCER CELLS

    Yuan, Fang2018

    Lysophosphatidic acid (LPA), a naturally-occurring, simple phospholipid, is present at elevated levels in the blood and ascites of ovarian cancer patients. LPA is a ligand of seven cell surface G protein-coupled receptors. It has been known as an oncogenic growth factor in ovarian cancer and other …

    vcu Repository record

  8. The Role of Autotaxin in Cancer

    Maggs, LaurenUniversity of Cambridge2023

    … (LPC) into lysophosphatidic acid (LPA). LPA is the agonist for at least six G protein coupled receptors whose activation stimulates cell proliferation, survival and migration. Overexpression of ATX and increased levels of LPA have been linked to fibrotic and inflammatory diseases …

    cambridge Repository record

  9. A Survey of the Agronomic and End Use Characteristics of Low Phytic Acid Soybeans

    Averitt, Benjamin JamesVirginia Tech2016

    … three distinct mutant alleles at the MIPS1, LPA1, and LPA2 genes resulting in up to a 75% reduction in PA. Low PA (LPA) soymeal-based feeds have been tested on several agricultural species and shown to reduce the P in the animal effluent, but they have not been tested on any aquacultural …

    vt Repository record

  10. Identifikation von Lysophosphatidsäure als Thrombozyten-aktivierende Substanz milde oxidierter Lipoproteine

    Zangl, Konrad JosefLudwig-Maximilians-Universität

    … Arbeit wird ein bislang unbekannter Weg der LPA-Entstehung während der Modifikation von Lipoproteinen nachgewiesen und die entstandene LPA mit Hilfe einer neu etablierten Methode der sequentiellen Lipidextraktion von Lipoproteinen quantifiziert. So findet sich während der milden Oxidation von …

    lmu-germany Repository record

  11. The association between light physical activity and cognition among adults: A scoping review

    Erlenbach, Emily DUniversity of Illinois at Urbana-Champaign2020

    … However, recently light physical activity (LPA) has become an area of interest. Historically treated as a “control” condition in exercise research, recent evidence suggests that LPA may exert its own health benefits, independent of MVPA engagement. These recent studies have primarily focused …

    uiuc Repository record

  12. Reactive Oxygen Species are Second Messengers in the Lysophosphatidic Acid Induced Survival Signaling of Ovarian Cancer

    Saunders, Jerry Allen JrWake Forest University2009

    … cancer is the activity of lysophosphatidic acid (LPA), a constitutively produced lipid mediator that is a potent agonist of signaling cascades that promote tumor growth and survival, including the PI3K/ Akt, MAPK/ ERK, and NF-κB pathways. We found that these signaling cascades are increased in …

    wfu Repository record

  13. Characterization of Mycobacterium tuberculosis isolates with discordant rifampicin susceptibility test results

    Ghebrekristos, YonasDepartment of Clinical Laboratory Science2018

    … (Xpert) is confirmed by a line probe assay (LPA) (GenoType MTBDRplus) and/or phenotypic (culture-based) drug susceptibility testing (DST) by MGIT (Mycobacterial Growth Indicator Tube) on the culture isolate from a 2nd specimen. Although both the Xpert and LPA target the rifampicin resistance …

    cape-town Repository record

  14. Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers

    Alpturk, OnurChemistry2022

    … prior studies. In MeOH, lysophosphatidic acid (LPA), a biomarker for several pathological conditions including ovarian cancer, is selectively detected by the europium complex. LPA is also detected via a fluorescence increase in human plasma samples. The 2-sn-OH moiety of LPA plays a key role in …

    lsu-thes Repository record

  15. The Design and Synthesis of Autotaxin Inhibitors and Analogs of Lysophosphatidic Acid

    Gupte, Renuka Niranjan2016

    <p>Lysophosphatidic acid (LPA) is a naturally occurring bioactive phospholipid. It has a wide array of biological effects like cell proliferation, survival, migration, apoptosis invasion, wound healing and angiogenesis. Autotaxin (ATX) was identified as an autocrine tumor cell motility factor from …

    tenn-hsc Repository record

  16. Lineáris poliakrilamiddal borított kapillárisok előállítása fehérjék kapilláris zónaelektroforetikus elemzéséhez

    Zagyi, Bálint2023

    Munkánk során LPA-val bevont kapillárisokat készítettünk. A bevonat kialakítása három fő lépésből állt: a kvarc kapilláris felületének előkezelése (etching), a polimert tartó átmeneti, középső réteg kötése a protonált szilanol csoportokhoz (szililezés), és a szilil reagensen a polimer felső réteg …

    debrecen Repository record

  17. Middle School Students' Perceptions of and Responses to the Inclusion of Culturally Relevant Units in the Physical Education Curriculum

    Braga, Luciana Carvalhal2019

    … examined how less predisposed to be active (LPA) and more predisposed to be active (MPA) students perceived and responded to the inclusion of archery, mountain biking, and slacklining in PE. Methods: A mixed methods design was employed, in which the results of an initial quantitative phase …

    wvu Repository record

  18. Βιβλιογραφική ανασκόπηση κλινικών μελετών που εξετάζουν το ρόλο της λιποπρωτεΐνης α (Lpa) στην καρδιαγγειακή νόσο / The role of lipoprotein (a) in cardiovascular disease: a literature review of clinical evidence

    Μπάλιος Ευάγγελος, Balios Evangelos2026

    Τα αποτελέσματα της λιποπρωτεΐνης (α), (Lp(a), έχουν συσχετιστεί γενικότερα με αυτά της καρδιαγγειακής νόσου (CVD), μεταξύ των γενικών πληθυσμών. Ωστόσο, η σχέση μεταξύ των αποτελεσμάτων της Lp(a) και καρδιαγγειακού κινδύνου λόγω αθηρωμάτωσης (Atherosclerotic Cardiovascular Disease - ASCVD) σε …

    athens Repository record

  19. Lysophospholipide als Modulatoren proinflammatorischer und thrombogener Signalwege in humanen Endothelzellen und Thrombozyten

    Retzer-Lidl, MichaelaLudwig-Maximilians-Universität

    … von LDL zur Bildung von Lysophosphatidsäure (LPA) kommt, und daß LPA die spezifische Thrombozyten- aktivierende Substanz im milde oxidierten LDL ist, in dieser Arbeit in in vitro Modellen untersucht, ob LPA und das strukturell und funktionell verwandte Lysophospholipid Sphingosin- 1-Phosphat …

    lmu-germany Repository record

  20. Genome and Transcriptome Based Characterization of Low Phytate Soybean and Rsv3-Type Resistance to Soybean Mosaic Virus

    Redekar, Neelam R.Virginia Tech2015

    … and 'genomics' approaches. The low phytic acid (lpa) soybean is more desirable than conventional soybean, as phytic acid is an anti-nutritional component of seed and is associated with phosphorus pollution. Despite the eco-friendly nature of the lpa soybean, it shows poor emergence, which reduces …

    vt Repository record

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