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Showing 1 to 20 of 136 for “"LOX"”.
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Early Plume Development and NOx Chemistry in LOx/H₂ and LOx/CH₄ Liquid Rocket Engines
Projected rocket launch demand in the next 10 years predicts an order-of-magnitude increase in CO₂-equivalent gasses. Despite this expected increase in launch frequency, the on-Earth environmental impacts of off-Earth missions is still understudied, partially due to the lack of combustion and …
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Cre-lox-basierte Inaktivierung des Pbx3-Gens
… Mäusen untersucht. <br>Zur Herstellung eines Cre-lox-basierten „Targeting“-Vektors wurde ein Teil der Genregion des Pbx3-Genes subkloniert und das Exon 3 als Zielsequenz sowie syngene DNA zur homologen Rekombination in den pFlox-Vektor eingefügt. Das linearisierte Rekombinationskonstrukt GB24new …
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Numerical Modelling of LOX Droplet Combustion in Hydrogen under Micro-gravity Conditions
… liquid rocket propellant configurations is LOX/LH2. Specifically,since this fuel/oxidizer mixture produces an extremely high specific impulse (Isp) with only water vapor as an exhaust. This makes LOX combustion research critical for improving combustion efficiency and avoiding flame …
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Charakterisierung von Epidermis-Typ-Lipoxygenasen mit besonderer Berücksichtigung der e-LOX-3
… epidermalen Lipoxygenasen, insbesondere die e-LOX-3, näher charakterisiert. Während für die epidermalen Enzyme im Vergleich zu konventionellen Lipoxygenasen geringe Enzymaktivitäten mit typischen Lipoxygenasesubstraten, wie Arachidonsäure, nachgewiesen wurden, war die e-LOX-3 inaktiv. Weitere …
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Measurement of Efficiency of Cre-mediated Recombination between lox loxSites Using a New Vector System
… Cre-mediated recombination efficiency between 'lox sites' using a new vector system. MATERIAL AND METHODS: A new vector (pFGB) to analyze Cre-mediated recombination efficiency between two lox sites was constructed. The combinations of wild type and mutant lox sites that are lox wt, M2, M3, M7, …
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Impact of Epa and Dha Supplementation and 15-Lox-1 Expression On Colitis and Colitis-Associated Colorectal Cancer
… cancer (CAC). The enzyme 15-lipoxygenase-1 (15-LOX-1) is crucial to converting omega-3 fatty acid derivatives eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to resolvins, potent anti-inflammatory products. 15-LOX-1 effects on the conversion of EPA and DHA to resolvins that …
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Untersuchungen zur Rolle von stress-induzierbaren Lipoxygenase-Aktivitäten in Weizen
Lipoxygenases (LOX) catalyze the hydroperoxidation of unsaturated fatty acids. Depending upon the site of the hydroperoxy insertion LOX-isoforms are classified into a 9-LOX family and a 13-LOX family, respectively. It has been documented in a large number of earlier investigations that LOX activity …
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ROLES OF 15-LIPOXYGENASE-2 (ALOX15B) IN SUPPRESSION OF TUMOR FORMATION, METASTASIS, AND SENSITIVITY TO CHEMOTHERAPY
15-LOX-2 is a member of the lipoxygenase family with anti-tumorigenic activity. Like other lipoxygenase families, the main substrate for 15-LOX-2 in the Arachidonic acid. The main product of this enzyme is 15(S)-HETE. 15(S)-HETE control the proliferation in prostate cells. The expression of …
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A Novel Function For 12-Lipoxygenase In C-Met And Integrin β4 Axis Crosstalk
… beta4, and the lipid enzyme, 12-Lipoxygenase (12-LOX). Therefore we sought to determine if beta4, c-MET and 12-LOX comprise a signaling axis. c-Met is implicated in cancer cell dissemination through regulation of invasion in EMT where cell-cell junctions are disturbed to allow motility. …
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Differences in lipoxygenase activity as related to cultivar differences in superficial scald of apples
The relationship between lipoxygenase activity (LOX) and superficial scald was studied in the four apple cultivars (Malus domesticus Borkh.), Granny Smith (GS), Red Delicious (RD), Golden Delicious (GD) and York (YK) to determine if LOX is the genetic source of superficial scald or a means of …
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Investigating the role of IL-4/IL-13 signalling through the IL-4 receptor alpha (IL-4Rα) on keratinocytes in murine models of Leishmania major and Schistosoma mansoni
… IL-4Rα deficient (KRT14creIL-4Rα-/lox) BALB/c and C57BL/6 mice were generated by gene targeting and site-specific recombination (cre/loxP) under control of the KRT14 locus. In the L. major footpad model, KRT14creIL-4Rα-/lox BALB/c mice developed increased swelling, high parasite …
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The role of IL-4Rá in Nippostrongylus brasiliensis-induced chronic lung pathology
… on macrophages and neutrophils (LysMCreIL-4Rá-/lox), IL-4Rá -/- and control mice (IL-4Rá-/lox) with N. brasiliensis and examined lung pathology at days 5, 42 and 180 post infection (p.i.).All three mice strains showed similar emphysemic-like pathology (alveolar dilatation) and airway …
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Biophysical Investigation into the Protein Dynamics Governing the Allosteric Regulation of Plant and Animal 15-Lipoxygenases
Lipoxygenases (LOXs) are a family of enzymes found in plants, animals, fungi, and bacteria that catalyze the per-oxidation of polyunsaturated fatty acids. In plants, LOXs are involved in growth, development, and defense against pathogenic attacks. There are also multiple isoforms present in humans, …
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THE CHARACTERIZATION OF BEHAVIORAL ABNORMALITIES IN BDNF LOXP TRANSGENIC MICE
<p>BDNF homozygous floxed mice (BDNF<sup> lox+/+</sup>) are a transgenic mouse strain used to study the neurotrophin brain-derived neurotrophic factor (BDNF) through Cre-Lox recombination when crossed with the appropriate Cre-expressing strain. BDNF<sup> lox+/+</sup> mice contain two artificially …
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Detection, causes and consequences of sex chromosome mosaicism
… Y (LOY) and female mosaic loss of chromosome X (LOX), is the most common form of clonal haematopoiesis (CH) that can be defined as the age-related clonal expansion of blood cells with somatic mutations. With the decreased cost of sequencing, the development of new bioinformatics methods and the …
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New fatty acids, oxylipins and volatiles in microalgae
… punctiforme PCC 73102 waren zwei Lipoxygenasen (LOXen) kodiert, in Nostoc sp. PCC7120 (identisch zu SAG 25.82) eine bifunktionelle LOX, wobei der N-terminale Bereich höchste Homologie zu einer Peroxidase zeigte, während der C-Terminus höchste Homologie zu einer LOX zeigte. Die rekombinanten …
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Étude de l’importance de la lipoxygénase dans la résistance à la gale commune de la pomme de terre
… inhibiteurs de protéase et lipoxygénases (LOX) a été mise en évidence. Les LOX ont beaucoup d’importance puisqu’elles peuvent jouer un rôle important dans la gestion des interactions plante - agent pathogène, en activant des mécanismes de réponse et de défense tels que la génération de …
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Investigating role of IL-4 receptor alpha (IL-4Ra) in murine models of atopic dermatitis
… on various B and T cells. We used mb1creIL-4Rα-/lox (mice lacking IL-4Rα on B cells), iLcKCre IL-4Rα-/lox (mice lacking IL-4Rα on all T cells), LcKCre IL-4Rα-/lox (mice lacking IL-4Rα on CD4+ and CD8+ T cells), CD4Cre IL-4Rα-/lox (mice lacking IL-4Rα on CD4+ Tcells), Foxp3Cre IL-4Rα-/lox (mice …
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