Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 105 for “"LOH"”.
-
Genetic Alterations in Advanced Head and Neck Cancer
… head and neck (SCCHN) loss of heterozygosity (LOH) at 10q has been described to be associated with poor prognosis. Moreover, genetic instability of microsatellite repeat sequences (MI) seems to concur with PTEN mutation in endometrial and colorectal cancer. <br>We screened a panel of SCCHN for …
-
THE ROLE OF DMP1 IN HUMAN BREAST CANCER PROGNOSIS AND CYCLIN D1-INDUCED BREAST CANCER
… to be explored. In Chapter II, we show that the LOH of the DMP1 locus was found in 42% of human breast carcinomas, and the LOH of INK4a/ARF and p53 were found in 20% and 34% of the cases, respectively. The LOH of DMP1 was mutually exclusive from that of INK4a/ARF and p53 and it was associated …
-
The long-term effects of testosterone replacement therapy in aging males with late-onset hypogonadism
Late-onset hypogonadism (LOH) is a pathological disorder that develops in males over the age of 40 and is diagnosed upon strict criteria that requires that the individual have total serum testosterone (T) below the normal limits as well as three symptoms of sexual dysfunction. Recommended therapy …
-
Aberrations of A Putative Tumor Suppressor Gene Sel1L In Pancreatic Ductal Adenocarcinoma
… by somatic mutation, loss of heterozygosity (LOH), CpG island hypermethylation and/or aberrantly expressed microRNAs (miRNAs).</p> <p><strong>Material and methods: </strong>In 42 PDAC tumors, the <em>SEL1L</em> coding region was amplified using reverse transcription polymerase chain reaction …
-
Analysis of the relationship between genomic instability, heterozygosity levels and phenotype in Saccharomyces cerevisiae
… independent events of loss-of-heterozygosity (LOH) accumulating over one or a few generations of mitotic cell division. We named this outcome "systemic genomic instability". The occurrence of this phenomenon was initially identified in the heterozygous yeast strain JAY270, and then validated in …
-
Clonal Dynamics in Barrett's Oesophagus and Oesophageal Adenocarcinoma
… frequent changes are loss of heterozygosity (LOH) events, which start to be observed in non-dysplastic IM. The most frequently mutated driver gene is TP53, with this mutation typically occurring in dysplastic BO. Hypothesis A deeper understanding of clonal dynamics and evolution within BO and …
-
Consequences of mitotic loss of heterozygosity on genomic imprinting in mouse embryonic stem cells
… on the mechanism of loss of heterozygosity (LOH) in that cell line. Certain genes analyzed, such as Peg10, Sgce, Peg1, and Mit1 showed abnormal expression in ES cell lines for which they were mUPD. These abnormal expression levels are similar to that observed in ES cells with …
-
Prognostic Significance of Chromosome 9p Deletion in Clear Cell Renal Cell Carcinoma
… involving chromosome 9p21 in particular LOH at the coding region of CDKN2A portends a worse prognosis in ccRCC in long term follow up and also validate the findings from I-FISH-based analysis of 9p deletion. Sixty percent of cases with LOH detected by microsatellites were copy number …
-
Repetitive Sequences Drive Rapid Adaptation in Candida albicans
… variations (CNVs) and loss of heterozygosity (LOH) confer increased virulence and antifungal drug resistance, yet the mechanisms and dynamics that drive these types of genome plasticity are not completely understood. In this dissertation, we build on foundational studies that identified …
-
Análise cromossômica por microarray em pacientes com deficiência intelectual associada à obesidade
… 20 pacientes, dos quais quatro apresentaram LOH, sendo que um deles no cromossomo 11, na região da síndrome de Bardet-Biedl, permitindo assim o diagnóstico da síndrome. Em um paciente foi detectada uma deleção de cerca de 7,9Mb no cromossomo 2, considerada patogênica. Dois pacientes tinham …
-
Analyse genomischer Aberrationen gastraler Marginalzonen B-Zell-Lymphome vom MALT-Typ
… in Form von Deletionen (loss of heterozygosity, LOH) oder Amplifikationen von Bedeutung. Die mit 20,8% der untersuchten Fälle am häufigsten gefundene Aberration war die Amplifikation der Region 3q26.2-27, welche den BCL-6- bzw. den PIK3CA-Genlocus beinhaltet. Auch wurden Amplifikationen des …
-
Erk1 and Erk2 in hematopoiesis, mast cell function, and the management of Nf1-associated leukemia and tumors
… therapy. While NF1 loss of heterozygosity (LOH) in myeloid progenitor cells sufficiently engenders leukemogenesis, plexiform neurofibroma formation depends on LOH in Schwann cells and Nf1 heterozygosity in the hematopoietic system. Specifically, recruited Nf1+/- mast cells accelerate …
-
An investigation of the mechanism of PAX7 mediated oncogenesis via in silico and in vitro biology
… act similarly on all three genes. Regions of LOH, usually arising as a result of either hemizygous deletion or gene conversion events, are typically defined as stretches of chromosomal areas where all heterozygous and thereby informative alleles are rendered homozygous in the cancer. This …
-
Analysis of prognostic and drug resistance markers in lung cancer
… locus resides here. This loss of heterozygosity (LOH) has been demonstrated to be a poor prognostic indicator in patients with primary adenocarcinoma of the lung. In this translational research project the role of mismatch repair (MMR) and LOH in patients with lung cancer has been further …
-
Information technology outsourcing by large Australian organisations
… satisfaction. Authors Lee, J-N (2000) and Loh & Venkatraman (1992) argue that outsourcing IT functions to external service providers is done in order to acquire economic, technological and strategic advantage. In this thesis, it is proposed that the main driver for outsourcing IT has …
-
Human common fragile site FRA16D flexibility peak is not a strong mitotic: Recombination hotspot in <i>saccharomyces cerevisiae</i>
… events that lead to loss of heterozygosity (LOH) on chromosome III in <em>Saccharomyces cerevisiae</em>. Two experimental yeast strains containing flexibility peak Flex1-(AT)15 from FRA16D were compared to a control strain lacking the Flex1 sequence in their ability to induce mitotic …
-
The candidate tumour suppressor, XIAP associated factor 1 (XAF1), directly inhibits XIAP activity and induces G1 phase cell cycle arrest
… xaf1 showed significant loss of heterozygosity (LOH) in this region. The loss of xaf1 expression and significant LOH near the xaf1 gene indicate that the down-regulation of XAF1 may be important in the development of the transformed phenotype.
-
Genomic analysis of mouse tumorigenesis
… Biosystems) to detect loss of heterozygosity (LOH) in mouse tumors. The murine version of ROMA was tested on DNA from early-stage KrasGJ2D-derived lung cancers and metastatic retinoblastoma in mice with retinal-specific Rb and p130 deletions. We were interested in identifying the additional …
-
An investigation of basic science and clinical research methodologies to benefit clinical practice
… ovarian cancer, 2) report the existence of micro-LOH (loss of heterozygosity) in ovarian endometriosis through a SNP 100K DNA array. Chapter 2 explores the efficacy of interventions to treat menstrual abnormalities using clinical cohort studies. Furthermore, Chapter 2 highlights how negligence in …
-
Functional analysis of ANKRD11 and FBXO31: two candidate tumour suppressor genes from the 16q24.3 breast cancer loss of heterozygosity region.
Loss of heterozygosity (LOH) on the long arm of chromosome 16 is frequently observed during the onset of breast cancer. Our laboratory has recently identified both ANKRD11 and FBXO31 as candidate tumour suppressor genes in the chromosome band 16q24.3, which is the smallest region of overlap for …
Page 1 of 6