Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 84 for “"LNCaP"”.
-
Funktionelle Analyse des Prostate-derived-Ets-Factors (PDEF) in der Prostatakarzinomzelllinie LNCaP
… der androgensensiblen Prostatakarzinomzelllinie LNCaP analysiert. LNCaP-Zellen wurden mit siRNA gegen PDEF transfiziert. Als Kontrolle diente siRNA gegen das im Menschen nicht vorkommende Luciferasegen (LUC). Die Zellproliferation wurde mit dem BrdU-Assay ermittelt und der Bestimmung der …
-
The Effects of Selenium on Estrogen-regulated Gene Expression in LNCaP Prostate Cancer Cells
… genes in human prostate cancer cells (LNCaP) treated with control (50 nM) or high (5 ìM) concentrations of Se. High Se treatment resulted in a non-significant 16 % decrease in ER binding to the estrogen response element (ERE), and no significant changes were found in expression levels …
-
Metabolomic and metabolomic flux studies of the effects of sphingosine kinase inhibitors on prostate cancer cells using high-resolution mass spectrometry as an analytical technique
… including the glycolysis in androgenin dependent LNCaP-AI prostate cancer cells.;The LNCaP-AI cell line was treated with SKi in the presence of 13C6-glucose for 24 hours before extraction and global metabolite analysis of cell lysate by LC-MS. The levels of glycolytic metabolites, pentose …
-
“Differential regulation of PTHrP gene expression by 1,25(OH)2D3 in prostate cancer cell lines”
… levels in the human prostate cancer cell lines LNCaP, C4-2, and PC-3. These cell lines represent early to advanced stages of prostate cancer, since LNCaP cells are weakly metastatic, androgen receptor (AR)-positive and androgen-responsive cells, C4-2 cells are AR-positive and …
-
Characterization of Gene Expression During Adenosine 3':5'-Cyclic Monophosphate Induced Neuroendocrine Differentiation in Human Prostatic Adenocarcinoma
The LNCaP cell line is a versatile and useful model that is suitable for the study of human prostate cancer in vitro. The elevation of LNCaP intracellular cAMP levels through the addition of membrane permeable cAMP analogues, phosphodiesterase inhibitors, adenylate cyclase activators, or components …
-
Androgen Receptor and Prostate Cancer Cell Heterogeneity
… by generating RFP-tagged AR<sup>+</sup> LNCaP clones with zinc finger nucleases (ZFNs) and isogenic AR knockout (AR-KO) LNCaP clones with CRISPR-cas9 technology. With the novel genetically matched clones, we demonstrate that the AR<sup>+</sup> and AR-KO clonal LNCaP cells manifest …
-
Phage Display Library Screening For Psa-/Lo Prostate Cancer Cell-Binding Peptides
… we employed highly purified PSA<sup>-/lo</sup> LNCaP PCa cells to perform phage display library screening. Our preliminary efforts identified two peptides, JRM1 and JRM2 that displayed preferential binding to PSA<sup>-/lo</sup> PCa cells.</p> <p>We first identified a potential peptide that may …
-
Preservation of Bioactive Compounds in Blueberry Fruit
… the growth of hepa-1c1c7 mouse liver cancer and LNCaP human prostate cancer cells without cytotoxicity, and inhibited adhesion of E. coli bacteria implicated in urinary tract infections. In an experiment comparing antiproliferation activity of wild and cultivated (Vaccinium corymbosum L.) …
-
Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
… One phage clone with a high binding affinity to LNCaP cells was identified. Cell phage ELISA and immunostaining demonstrated high specificity of this phage to LNCaP cells. The fluorescein labeled KYL peptide exhibited higher binding to LNCaP cells in comparison to other cells. The fusion peptide …
-
Application of Different Bioanalytical Workflows for Proteomics of Prostate Cancer
… a large scale in prostate cancer focused on the LNCaP human prostate cancer cell line, and on human prostate cancer tissue. </p> <p>For the LNCaP prostate cancer cell line, we applied a combination of analytical platforms: (1) a novel in-gel isoelectric focusing (IEF) LC-MS/MS analytical …
-
Investigations on the effects of Typha capensis on male reproductive functions
… capensis rhizomes. Part 1: TM3-Leydig cells and LNCaP cells incubated with different concentrations of crude aqueous extract of T. capensis rhizomes (0.01, 0.02, 0.1, 1, 10 and 100 µg/ml) and control (without extract) for 24 and 96 hours, after incubation. The following parameters were evaluated: …
-
Testing Whether MRP4 (a cAMP Efflux Pump) and the Beta 2 Andrenergic Receptor (an Upstream Regulator of cAMP Signaling Pathways
… and in human prostate cancer cell lines such as LNCaP cells [Cai, C., et al., Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells. Prostate Cancer Prostatic Dis, 2007. 10(1): p. 39-45]. In these cells, there are reports that the !2 adrenergic …
-
The effect of cAMP elevation on intracellular signalling pathways in prostate epithelial cells
… IL-6-induced STAT3 activation in the DU145, LNCaP and PZ-HPV-7 prostate epithelial cells. Elevation of cAMP attenuated IL-6-mediated activation of STAT3 which was mimicked via selective activation of the exchange protein activated by cAMP. Inhibition of protein kinase A (PKA) alone also …
-
CaV1.3 Ion channel expression and hormone therapy in prostate cancer
… within subcellular compartments. Treatment of LNCaP cells with AR antagonist, Enzalutamide resulted in the re-localisation of CaV1.3 to the plasma membrane where calcium imaging techniques highlighted the presence of depolarisation-induced calcium responses in a subpopulation of cells. …
-
Inhibition des 26s Proteasoms : molekularer Mechanismus der Hyperthermie in Prostatakarzinomzellen?
… beeinflußt. <br>Humane PK- (PC-3, LNCaP, DU-145), Glioblastom- (A172), Melanom- (A375) und Bronchialkarzinomzellen (A549) und murine PK-Zellen (TRAMP C1, TRAMP C2) wurden hyperthermiert (1 Stunde, 44 Grad C, +/- 20Gy, +/- Cycloheximid). Im zellulären Proteinextrakt wurde die …
-
Cellular response to 11[beta]-dichloro, a novel aniline mustard-estradienone, in various prostate cancer cell lines
… prostate cancer cell lines were used, namely, LNCaP (AR-positive, T887A), PC3 (AR-negative, p53 inactive), DU145 (AR-negative, p53 null), and the isogenic pair PC3-AR (AR-positive) and PC3-neo (AR-negative), which only differ in the AR status. Growth inhibition with LNCaP, PC3, and DU 145 cells …
-
Leukemia/Lymphoma Related Factor in Human Prostate Carcinoma
… cells, RWPE-1, and prostate cancer cells, LNCaP (androgen sensitive) and PC3 (androgen-insensitive), were used to examine LRF/Pokemon expression by immunocytochemistry and immunofluorescence. The mean immunofluorescence intensity of LRF/Pokemon was significantly higher in PC3 and LNCaP …
-
Investigating PLEKHS1 adaptor function in PI3K signalling and human cancer biology
… PLEKHS1 adaptor protein function *in vitro*, LNCaP prostate cancer cell line is used due to its PTEN-null status and PI3K pathway hyperactivation. Transient over-expression of PLEKHS1 in LNCaP cells generates a robust PIP<sub>3</sub> response via YxxM-dependent interactions with endogenous …
-
Angiotensin-(1-7) Reduces Prostate Cancer Growth and Metastasis by Altering the Tumor Microenvironment
… agent. In this study, athymic mice with human LNCaP xenografts were infused with saline or Ang-(1-7) (24 g/kg/h) for 54 days. The heptapeptide markedly reduced tumor volume and wet weight as compared to saline administration. Tumors from mice treated with Ang-(1-7) had a 78% reduction in Ki67 …
-
Cell Toxicity and Uptake of RRR-Alpha-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) by Various Cell ines <em>In Vitro</em>.
… Cytotoxicity assays with RAW 264.7 and LNCaP cells incubated overnight with TPGS or α-TS at concentrations ≥ 12.4 μM suggest that α-TS is more cytotoxic than TPGS. Macrophages were found to be more sensitive than LNCaP cells when treated with similar concentrations of α-TS. For both cell …
Page 1 of 5