Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"LL37"”.
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Immune Recognition of Self Nucleic Acids Driven By Endogenous Antimicrobial Peptides: Role In Autoimmunity
… the endogenous cationic antimicrobial peptide LL37, which are internalized into the endosomal compartments and thus can access TLR9. We investigated whether this endogenous peptide can also interact with extracellular self-RNA and lead to DC activation. We found that LL37 binds self-RNA as well …
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ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
… tryptase release in response to the Cathelicidin LL37. Furthermore, absence of GRK2 resulted in increased cutaneous vascular permeability in response to C48/80 in vivo. By contrast, LL37-injection induced rosacea-like erythema, generation of matrix metalloproteinase 9 (MMP9), chemokine, CXCL2, and …
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The interaction of antimicrobial peptides with lipopolysaccharide aggregates and model membranes.
… cationic antimicrobial peptides (CAPs) LL37 and LFb possess putative anti-endotoxic activities and were therefore studied using small-angle neutron scattering (SANS) and cryo transmission electron microscopy (cryo-TEM) to assess any modication induced to the colloidal structure of LPS, …
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The Role of MRGPRX2/Mrgprb2 in Regulating Mast Cell Function
… 3 number"of"MCs"compared"to"normal"subjects."AMP"LL37"and"neuropeptide"(NP)" substance"P"(SP)"are"upregulated"in"rosacea."LL37"and"SP"activate"MCs"through" MRGPRX2"in#vitro.#Utilizing"Mrgprb2"knockout"mice"(Mrgprb2E/E)"we"demonstrated" a" reduction" in" erythema" presentation," inflammatory" cell" …