Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"LL-37"”.
-
LL-37 and citrullinated LL-37: differential modulation of the oxylipin - chemokine axis
… system, and it involves a complex network of cellular and molecular events. In the lungs, human bronchial epithelial cells release cytokines/chemokines, and other mediators such as bioactive lipids and cationic host defence peptides (CHDPs) to facilitate and regulate airway inflammation. …
-
Immunomodulatory effects of LL-37 in the epithelia
The cationic host defence peptide LL-37 is an immunomodulatory agent that plays an important role in epithelial innate immunity. Previously, concentrations of LL-37 thought to represent levels present during inflammation have been shown to elicit the production of cytokines and chemokines by …
-
Synthesis of an isotopically labelled analog of the antimicrobial peptide ll-37
<p>LL-37 is a cationic cathelin-associated broad spectrum antibiotic peptide of human neutrophils. Its mechanism of action is by disruption of the bacterial cell membrane structure. LL-21 is a simplified form of the peptide that contains only the core portion of LL-37, which retains antimicrobial …
-
Fragments of the human antimicrobial LL-37 and their interaction with model membranes
… bacteria, viruses, fungi and even cancer cells. Their advantage is that their target is the cell membrane, in contrast to antibiotics which disturb the metabolism of the respective cell type. This allows AMPs to be more active and faster. The lack of an efficient therapy for some cancer …
-
Expression und Regulation des antimikrobiellen Cathelicidin-Peptids LL-37 in humanen Kolonepithelzellen, Monozyten und PBMC
… Butyrat hat paradoxe Effekte auf Epithelzellen des Kolons: Hauptenergieträger und Wachstumsstimulator normaler Mukosa einerseits, Proliferationshemmer und Apoptoseinduktor kolorektaler Karzinomzellen in vitro andererseits. Butyrat kann zudem die Immunfunktionen der Schleimhaut modulieren. …
-
Impact of cationic host defence peptide LL-37 on human neutrophil death and inflammatory responses
… of apoptotic PMN, in contrast to necrotic cells, is proposed to promote the resolution of inflammation. In this thesis I demonstrate that the human cathelicidin LL-37 rapidly induced secondary necrosis of apoptotic human PMN and identify the essential C-terminal region of LL-37 required for …
-
The Design of Antimicrobial Detachable Thin Films for the Study of Hepatic Infections
… approaches. In this work, we modified collagen/hyaluronic acid polyelectrolyte multilayers (PEMs) with the natural antimicrobial peptide, LL-37 to study hepatic infections. LL-37 was physisorbed and covalently linked to the surface of the PEMs. Escherichia coli DH10B were cultured in the …
-
Expression of antimicrobial peptides in human lung tissue
… rannsókn var návist örverudrepandi peptíðsins LL-37 í lungnavef og í lungnastofnfrumulínunni VA10 staðfest og tjáning LL-37 var betur skoðuð. Í ljós kom að LL-37 var tjáð á topplægum hluta þekjufrumna berkjunga, en þekjufrumur lungnablaðranna sýndu enga tjáningu. Þegar VA10 frumulínan var …
-
Actions of Antimicrobial Peptides and Bacterial Components in Inflammation
Antimicrobial peptides are evolutionally ancient parts of the innate immune system and their primary role is to protect us from infections. The human cathelicidin-derived antimicrobial peptide, LL-37, not only possesses broad spectrum antimicrobial activities but is also able to bind and neutralize …
-
Proteomic Investigation of Salivary Biomarkers in Periodontal Diseases
… using ELISA in the samples that had been initially screened using SELDI-TOF MS as well as in saliva samples in an independent cohort selected according to diabetic status rather than periodontal status. The effect of non-surgical periodontal therapy, diabetes, saliva sample collection method, …
-
Synthesis and solid state F-NMR studies on fluorine-labeled antimicrobial peptide RK-21
… act against bacteria by binding non-specifically and disrupting their outer membrane. LL-37 is the only member of the cathelicidin group of antimicrobial peptides present in humans and shows a broad range of antimicrobial activity. RK-21 is a fragment of human antimicrobial peptide LL-37, …
-
Investigating antimicrobial resistance mechanisms in Neisseria gonorrhoeae using peptide probes
… makes the treatment of gonococcal infections challenging. A major cause of resistance is the expression of a multidrug efflux pump termed MtrCDE, which exports a wide range of antimicrobial agents. Efflux pumps are membrane-bound systems and consequently challenging to study and target with …
-
건선 피부에서 Toll-like receptors와 antimicrobial peptides의 발현과 혈청 내 비타민 D과의 관계
… of the epidermal keratinocytes. Vitamin D, Toll-like receptors (TLRs), and antimicrobial peptides (AMPs) such as human beta defensins (HBDs) and cathelicidins (LL-37) can modulate the immune system through a variety of ways in psoriasis. Purpose: The objective of the present study was to …
-
TOLL-LIKE RECEPTOR EXPRESSION AND FUNCTION
… yet little is known about the role of toll-like receptors (TLR) which, upon activation, stimulate inflammation. The objective of this research was to determine: (1) baseline expression of TLRs in ocular surface cells, if TLR activation or products thereof (antimicrobial peptides, AMPs) …
-
Novel Endogenous Antimicrobial Peptides
… system. They are ancient molecules found in all classes of life. Antimicrobial peptides rapidly kill a broad spectrum of microbes and are immunomodulatory, i.e. having additional actions influencing inflammation and other innate immune responses. Results presented in this thesis demonstrate …
-
Surface proteins of Finegoldia magna interacting with the human host
… pathogen and isolated from ~10% of all anaerobic infections. Reoccurring taxonomical changes and the anaerobic growth have contributed to the neglect of F. magna. The present thesis describes the identification and characterization of two novel surface proteins of F. magna. One of the …
-
Host response in sepsis
… heart failure cause circulatory disturbances challenging the intensivist. Despite modern medication and high technology supportive care, mortality is high. Key strategies include to find and take care of causative agents at the infection site. Unfortunately, the microbes are sometimes “slippery …
-
Host modulation of excessive innate immune responses
… innate immune response has to be carefully balanced to avoid excessive inflammation with systemic consequences. The first part of this thesis is focused on molecular interactions between host-defense peptides and p33 (globular C1q receptor), a protein that can modulate cell injury. We …
-
Endocytosis of therapeutic macromolecules in tumor cells - Mechanistic aspects of the proteoglycan receptor function
… safe methods to deliver nucleic acids to intracellular sites of action is the main impediment to the introduction of nucleic acid based therapies in the clinic. Viral delivery methods have been demonstrated to efficiently deliver nucleic acids, but also to be associated with severe, occasionally …
Page 1 of 2