Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"LINE-1 retrotransposition"”.
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Fanconi Anaemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mammalian development
Long interspersed nuclear element 1 (LINE-1) is the only autonomous retrotransposon in humans and represents 17% of the genome. LINE-1 retrotransposition occurs by a “copy and paste” mechanism in which an RNA intermediate is reverse-transcribed and integrates at a new genomic location. LINE-1 …
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THE ROLE OF RETROTRANSPOSITION AND EXOSOMAL DNA IN RADIATION-INDUCED GENOMIC INSTABILITY
… possible that the random insertion nature of the LINE-1 retrotransposons could be a cause of RIGI. The work in this thesis has aimed investigate the role of retrotransposable elements in the mechanism of RIGI. Three different cell lines (HF19, Caco-2, and MCF7) were used to investigate if …
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Restriction of Retrotransposition and Retroviral Infection by RNase L and APOBEC3G
… a nuclease-dead RNase L mutant (R667A), impaired retrotransposition of both human LINE-1 and mouse IAP elements (Chapter 2). Depletion of endogenous RNase L with siRNA increased levels of LINE-1 retrotransposition. Wild type RNase L, but not RNase L R667A, dramatically reduced L1 RNA accumulation, …